We are analyzing https://link.springer.com/article/10.1186/ar3528.

Title:
Mechanisms of tissue injury in lupus nephritis | Arthritis Research & Therapy
Description:
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
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Keywords {🔍}

lupus, pubmed, google, scholar, nephritis, cas, disease, cells, renal, mice, systemic, central, erythematosus, patients, complement, kidney, immunol, expression, tissue, activation, injury, gilkeson, production, mrllpr, activity, role, stat, damage, glomerular, antibodies, immune, inflammatory, nitric, oxide, arthritis, ics, pathway, mechanisms, murine, increased, cell, autoimmune, factors, pathogenic, receptor, glomeruli, levels, reactive, present, development,

Topics {✒️}

orally administered ng-monomethyl-l-arginine l-ng-monomethyl-l-arginine therapy l-ng-monomethyl-l-arginine il17-producing cd4-cd8- double-negative t-cell-b-cell aggregates present mrl/lpr lupus-prone mice autoimmune mrl-lpr/lpr mice normal t-cell expressed ifn-inducible protein-10 relating charge/charge inter-actions intrarenal ifn-gamma expression membrane attack complex anti-dsdna/chromatin antibodies binding ifn-gamma receptor signaling macrophage inflammatory protein-1β macrophage inflammatory protein-1α renal interferon-gamma mrna anti-double-stranded dna short-term anti-cd20 pure anti-dsdna mabs macrophage colony-stimulating factor fas-intact mrl model mrl/lpr background resulted cell-mediated immune responses monocyte chemoattractant protein-1 ets factor/fli-1 expression immune-mediated inflammatory disorders lupus-prone mouse models nonpathogenic anti-dsdna antibodies igg anti-dsdna antibodies end-stage renal disease glomerular basement membrane additional b-cell functions mrl-lpr/lpr mice th1/th2 transcription factors membrane attack complexes lupus-prone mice prior immune complex formation/deposition renal cross-reactive antigens open-label trial nephritic mrl/lpr mice produce reactive nitrogen renal cytokine/chemokine profile progressive glomerular/tubular loss b-cell infiltrates significant igg/ic deposition lpr/lpr-induced autoimmunity genome-wide association study laser microdissection-based analysis mediating ic-induced inflammation

Questions {❓}

What is damaging the kidney in lupus nephritis?

Schema {🗺️}

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         headline:Mechanisms of tissue injury in lupus nephritis
         description:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
         datePublished:2011-12-21T00:00:00Z
         dateModified:2011-12-21T00:00:00Z
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            Membrane Attack Complex
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ScholarlyArticle:
      headline:Mechanisms of tissue injury in lupus nephritis
      description:Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
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         Membrane Attack Complex
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