We are analyzing https://link.springer.com/article/10.1186/ar3377.

Title:
MicroRNAs in systemic rheumatic diseases | Arthritis Research & Therapy
Description:
MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length. miRNAs have been shown to regulate gene expression and thus influence a wide range of physiological and pathological processes. Moreover, they are detected in a variety of sources, including tissues, serum, and other body fluids, such as saliva. The role of miRNAs is evident in various malignant and nonmalignant diseases, and there is accumulating evidence also for an important role of miRNAs in systemic rheumatic diseases. Abnormal expression of miRNAs has been reported in autoimmune diseases, mainly in systemic lupus erythematosus and rheumatoid arthritis. miRNAs can be aberrantly expressed even in the different stages of disease progression, allowing miRNAs to be important biomarkers, to help understand the pathogenesis of the disease, and to monitor disease activity and effects of treatment. Different groups have demonstrated a link between miRNA expression and disease activity, as in the case of renal flares in lupus patients. Moreover, miRNAs are emerging as potential targets for new therapeutic strategies of autoimmune disorders. Taken together, recent data demonstrate that miRNAs can influence mechanisms involved in the pathogenesis, relapse, and specific organ involvement of autoimmune diseases. The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease.
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Keywords {🔍}

pubmed, article, google, scholar, cas, mirnas, expression, arthritis, mira, mirna, patients, cells, central, diseases, systemic, cell, lupus, autoimmune, rheumatoid, microrna, chan, role, disease, colleagues, protein, sle, rheumatic, regulation, erythematosus, rheum, shown, target, synovial, expressed, factor, micrornas, pbmcs, including, human, inflammatory, inflammation, art, satoh, gene, processes, activation, identified, blood, synoviocytes, biomarkers,

Topics {✒️}

glycine-tryptophan dipeptide-rich protein cd4+cd25+foxp3+ treg cells endotoxin-induced differential cross-regulation dicer-dependent small rnas platelet-derived growth factor small expressed rnas systemic lupus erythematosus anti-ssb/la antibodies edward kl chan activation-induced cell death positive anti-ssa/ro pro-inflammatory chemokine rantes double-stranded microrna-15a develop collagen-induced arthritis double-stranded mir-15a called 'anti-su antibodies' anti-ago2/su antibodies antibodies 'anti-ago2/su' mirna-based gene therapies lupus research institute pro-inflammatory milieu typical t-cell receptor engagement mirna-mediated gene silencing ago-mediated repression requires primary anti-phospholipid syndrome mrl/lpr treg cells normal t-cell expressed rna-induced silencing complex affect pabp-dependent deadenylation lipopolysaccharide-activated rheumatoid fibroblast mirna-binding protein argonaute2 systemic rheumatic diseases patient full size image post-transcriptional regulatory mechanism bmc musculoskelet disord pro-inflammatory cytokine il-18 pro-inflammatory cytokine il-17 prolonged tnf-α production properly regulate traf6/irak1 single-stranded rnas systemic autoimmune diseases privacy choices/manage cookies polymyositis/dermatomyositis pm/dm demonstrated methylation-dependent regulation treadwell el autoimmune rheumatic diseases inflammatory chemokine rantes epidermal growth factor nf-kb pathway leading

Questions {❓}

Filipowicz W, Bhattacharyya SN, Sonenberg N: Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight?

Schema {🗺️}

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         headline:MicroRNAs in systemic rheumatic diseases
         description:MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length. miRNAs have been shown to regulate gene expression and thus influence a wide range of physiological and pathological processes. Moreover, they are detected in a variety of sources, including tissues, serum, and other body fluids, such as saliva. The role of miRNAs is evident in various malignant and nonmalignant diseases, and there is accumulating evidence also for an important role of miRNAs in systemic rheumatic diseases. Abnormal expression of miRNAs has been reported in autoimmune diseases, mainly in systemic lupus erythematosus and rheumatoid arthritis. miRNAs can be aberrantly expressed even in the different stages of disease progression, allowing miRNAs to be important biomarkers, to help understand the pathogenesis of the disease, and to monitor disease activity and effects of treatment. Different groups have demonstrated a link between miRNA expression and disease activity, as in the case of renal flares in lupus patients. Moreover, miRNAs are emerging as potential targets for new therapeutic strategies of autoimmune disorders. Taken together, recent data demonstrate that miRNAs can influence mechanisms involved in the pathogenesis, relapse, and specific organ involvement of autoimmune diseases. The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease.
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      headline:MicroRNAs in systemic rheumatic diseases
      description:MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length. miRNAs have been shown to regulate gene expression and thus influence a wide range of physiological and pathological processes. Moreover, they are detected in a variety of sources, including tissues, serum, and other body fluids, such as saliva. The role of miRNAs is evident in various malignant and nonmalignant diseases, and there is accumulating evidence also for an important role of miRNAs in systemic rheumatic diseases. Abnormal expression of miRNAs has been reported in autoimmune diseases, mainly in systemic lupus erythematosus and rheumatoid arthritis. miRNAs can be aberrantly expressed even in the different stages of disease progression, allowing miRNAs to be important biomarkers, to help understand the pathogenesis of the disease, and to monitor disease activity and effects of treatment. Different groups have demonstrated a link between miRNA expression and disease activity, as in the case of renal flares in lupus patients. Moreover, miRNAs are emerging as potential targets for new therapeutic strategies of autoimmune disorders. Taken together, recent data demonstrate that miRNAs can influence mechanisms involved in the pathogenesis, relapse, and specific organ involvement of autoimmune diseases. The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease.
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         Systemic Lupus Erythematosus
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         Systemic Lupus Erythematosus Patient
         Treg Cell
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         Orthopedics
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