We are analyzing https://link.springer.com/article/10.1186/ar3281.

Title:
Chromatin as a target antigen in human and murine lupus nephritis | Arthritis Research & Therapy
Description:
The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes. The latter deposition defines end-stage disease. This event is stringently linked to a renal-restricted shutdown of expression of the DNaseI gene, as determined by loss of DNaseI mRNA level and DNaseI enzyme activity. The major aim of the present review is to generate new therapeutic strategies based on new insight into the disease pathogenesis.
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Keywords {🔍}

lupus, pubmed, google, scholar, chromatin, nephritis, cas, antibodies, dnasei, renal, fragments, erythematosus, glomerular, systemic, cells, human, patients, dna, heparin, autoantibodies, sle, murine, disease, central, binding, nucleosomes, cell, antidna, data, rekvig, immune, exposed, matrix, nephritogenic, arthritis, complexes, potential, membranes, structure, increased, chaperone, antidsdna, structures, activity, molecules, rheum, immunol, pathogenic, autoimmunity, effect,

Topics {✒️}

isolated anti-double-stranded-dna antibodies anti-double-stranded dna antibodies trypsin-sensitive solvent-phase tails present t-antigen-derived peptides anti-extracellular matrix auto-antibodies nuclease/protease-resistant chromatin structure anti-dsdna antibody executes anti-dna antibody subpopulations polyreactive antinuclear auto-antibodies van bavel cc anti-dna moabs bind anti-dsdna auto-antibodies severe membrano-proliferative nephritis anti-dna auto-antibodies immune electron microscopy van bruggen mc anti-dsdna antibodies proposes anti-dsdna antibodies execute transmission electron microscopy anti-dna antibodies gain antibody-secreting plasma cells nephritogenic anti-dna antibodies pathogenic anti-dna antibodies trypsin-sensitive basic residues pathogenic anti-nucleosome antibodies induced anti-chromatin antibodies naïve peptide-specific cd4+ increased nuclease-mediated digestion dna-anti-dna complexes mrl-lpr/lpr mice [103] mrl-lpr/lpr mice b-cell-recognising dna relevant t-helper cells chromatin fragment-igg complexes activate antigen-presenting cells detailed evidence-based model dna-specific antigen receptor chromatin-reactive igg autoantibodies systemic lupus erythematosus privacy choices/manage cookies chromatin-igg complex deposition bind nephritogenic antibodies nephritogenic auto-antibodies pathogenic auto-antibodies nicked dna [82] antibodies cross-react chromatin-igg complex binding central target structures electron-dense structures anti-dsdna antibodies

Questions {❓}

Causal therapy of lupus nephritis: are there contours of new tracks in this landscape?
Pisetsky DS, Vrabie IA: Antibodies to DNA: infection or genetics?
Rekvig OP, Nossent JC: Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms?
Van Bavel CC, van der Vlag J, Berden JH: Glomerular binding of anti-dsDNA auto-antibodies: the dispute resolved?

Schema {🗺️}

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         headline:Chromatin as a target antigen in human and murine lupus nephritis
         description:The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes. The latter deposition defines end-stage disease. This event is stringently linked to a renal-restricted shutdown of expression of the DNaseI gene, as determined by loss of DNaseI mRNA level and DNaseI enzyme activity. The major aim of the present review is to generate new therapeutic strategies based on new insight into the disease pathogenesis.
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      headline:Chromatin as a target antigen in human and murine lupus nephritis
      description:The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes. The latter deposition defines end-stage disease. This event is stringently linked to a renal-restricted shutdown of expression of the DNaseI gene, as determined by loss of DNaseI mRNA level and DNaseI enzyme activity. The major aim of the present review is to generate new therapeutic strategies based on new insight into the disease pathogenesis.
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         Mesangial Matrix
         Histone Chaperone
         Rheumatology
         Orthopedics
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