We are analyzing https://link.springer.com/article/10.1186/ar3204.

Title:
Promise and pitfalls of the Immunochip | Arthritis Research & Therapy
Description:
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
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Keywords {🔍}

common, variants, gwas, studies, diseases, rare, heritability, chip, association, pubmed, article, immunochip, disease, loci, genotyping, chips, consortium, snps, large, identified, snp, study, variant, cnvs, nature, google, scholar, data, research, genetic, genomewide, missing, effects, designed, central, cas, privacy, cookies, brown, mapping, autoimmune, type, sample, information, publish, search, arthritis, matthew, identify, remaining,

Topics {✒️}

genome-wide association study enables cost-effective fine-mapping ancestry informative markers missing narrow-sense heritability gene-environment interaction studies dna methylation profiles provide cost-effective genotyping immunogenetics gene mapping established disease association association signal due powerful hypothesis-free method rare variant associations genetic variants contributing hypothesis-driven research genome sequencing studies immunogenetics research celiac disease case study fine-map established loci including rheumatoid arthritis privacy choices/manage cookies higher genetic resolution common heritable diseases study sample size high-density mapping marker selection article cortes immunogenetics studies gene-gene interaction linkage studies preceding sharing control data custom genotyping chips article number 101 large individual effects type rare cnvs genetic loci cardiovascular gene-centric 50 initial gwas studies direct association genetic basis informed genotyping strategies gene-environment interactions genotyping rare variants gene-gene interactions conditions privacy policy european economic area significance adverse effect low-hanging fruit recent meta-analysis achieved definite levels

Schema {🗺️}

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         headline:Promise and pitfalls of the Immunochip
         description:Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
         datePublished:2011-02-01T00:00:00Z
         dateModified:2011-02-01T00:00:00Z
         pageStart:1
         pageEnd:3
         sameAs:https://doi.org/10.1186/ar3204
         keywords:
            Celiac Disease
            Rare Variant
            Ancestry Informative Marker
            Genomewide Association Study
            Common CNVs
            Rheumatology
            Orthopedics
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ScholarlyArticle:
      headline:Promise and pitfalls of the Immunochip
      description:Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.
      datePublished:2011-02-01T00:00:00Z
      dateModified:2011-02-01T00:00:00Z
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         Rare Variant
         Ancestry Informative Marker
         Genomewide Association Study
         Common CNVs
         Rheumatology
         Orthopedics
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      name:Princess Alexandra Hospital
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               name:University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
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      name:Matthew A Brown
      affiliation:
            name:Princess Alexandra Hospital
            address:
               name:University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
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PostalAddress:
      name:University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia
      name:University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia

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