We are analyzing https://link.springer.com/article/10.1186/ar2366.

Title:
Role of resistin as a marker of inflammation in systemic lupus erythematosus | Arthritis Research & Therapy
Description:
Introduction Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral density (BMD) in female patients with systemic lupus erythematosus (SLE). Methods One hundred sixty-three female patients with SLE (20 to 82 years old) were examined in a cross-sectional study. Venous blood samples were analyzed for resistin, erythrocyte sedimentation rate (ESR), C-reactive protein, creatinine, fasting lipids, complements, tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, sIL-6R (soluble IL-6 receptor), ICTP (C-terminal telopeptide of type I collagen), and PINP (N-terminal propeptide of type I procollagen). Simple and multiple regression analyses as well as logistic regression analyses were performed. Resistin in serum was compared with 42 healthy female controls with respect to age. Results Serum resistin levels in controls were similar to those of patients with SLE. Markers of inflammation and current dose of glucocorticosteroids correlated positively to resistin in serum. Markers of renal function, number of prevalent vertebral fractures, and BMD were also significantly associated with resistin. In a multiple regression model, ESR, creatinine, C3, current glucocorticosteroid dose, high-density lipoprotein, and BMD radius remained significantly associated with resistin. In logistic regression analyses with resistin as the independent variable, a significant association was found with ESR (normal or elevated) but not with S-creatinine or z score for hip and radius total. Conclusion Although resistin measurements did not differ between patients and controls, resistin was clearly associated with general inflammation, renal disease, treatment with glucocorticosteroids, and bone loss. We hypothesize that resistin has proinflammatory and disease-promoting properties in SLE. Further studies are needed to elucidate the mechanism behind these associations.
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Keywords {🔍}

resistin, article, patients, pubmed, google, scholar, cas, inflammation, sle, lupus, systemic, levels, serum, disease, regression, erythematosus, bone, esr, analyses, variables, low, controls, renal, variable, study, arthritis, proinflammatory, bmd, table, function, female, total, markers, multiple, significantly, hdl, high, research, type, age, correlated, radius, significant, score, rheumatology, activity, gfr, correlation, dependent, marker,

Topics {✒️}

adipocyte-specific secretory factor dual-energy x-ray absorptiometry tumor necrosis factor-alpha erythrocyte sedimentation rate glomerular filtration rate cysteine-rich secreted protein vertebral fracture assessment biotin-labelled anti-resistin antibodies maria bokarewa & hans carlsten high-sensitivity c-reactive protein cystein-rich secretory adipokine article download pdf streptavidin-horseradish peroxidase conjugate anti-double-stranded dna immune-complex-mediated systemic lupus erythematosus bone mineral density disease-modifying antirheumatic drugs white adipose tissue helena forsblad d'elia ongoing lupus nephritis kolmogorov-smirnov normality test end-stage renal disease laboratory disease-related variables resistin messenger-rna expression prevalent vertebral fractures full access regional research sources rheumatology damage index apparent central position privacy choices/manage cookies forward stepwise method nuclear factor kappa compression fractures c-reactive protein proinflammatory cytokines tnf-α disease activity index bone resorption marker rheumatoid arthritis patients low-density lipoprotein high-density lipoprotein receiver operating characteristic standard laboratory techniques bone miner res forsblad d'elia venous blood samples current glucocorticosteroid dose reduced bone mass multiple regression model logistic regression analyses

Schema {🗺️}

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         description:Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral density (BMD) in female patients with systemic lupus erythematosus (SLE). One hundred sixty-three female patients with SLE (20 to 82 years old) were examined in a cross-sectional study. Venous blood samples were analyzed for resistin, erythrocyte sedimentation rate (ESR), C-reactive protein, creatinine, fasting lipids, complements, tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, sIL-6R (soluble IL-6 receptor), ICTP (C-terminal telopeptide of type I collagen), and PINP (N-terminal propeptide of type I procollagen). Simple and multiple regression analyses as well as logistic regression analyses were performed. Resistin in serum was compared with 42 healthy female controls with respect to age. Serum resistin levels in controls were similar to those of patients with SLE. Markers of inflammation and current dose of glucocorticosteroids correlated positively to resistin in serum. Markers of renal function, number of prevalent vertebral fractures, and BMD were also significantly associated with resistin. In a multiple regression model, ESR, creatinine, C3, current glucocorticosteroid dose, high-density lipoprotein, and BMD radius remained significantly associated with resistin. In logistic regression analyses with resistin as the independent variable, a significant association was found with ESR (normal or elevated) but not with S-creatinine or z score for hip and radius total. Although resistin measurements did not differ between patients and controls, resistin was clearly associated with general inflammation, renal disease, treatment with glucocorticosteroids, and bone loss. We hypothesize that resistin has proinflammatory and disease-promoting properties in SLE. Further studies are needed to elucidate the mechanism behind these associations.
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      headline:Role of resistin as a marker of inflammation in systemic lupus erythematosus
      description:Resistin is a cystein-rich secretory adipokine. It is proposed to have proinflammatory properties in humans. The aim of this study was to determine associations between serum levels of resistin and markers of inflammation and bone mineral density (BMD) in female patients with systemic lupus erythematosus (SLE). One hundred sixty-three female patients with SLE (20 to 82 years old) were examined in a cross-sectional study. Venous blood samples were analyzed for resistin, erythrocyte sedimentation rate (ESR), C-reactive protein, creatinine, fasting lipids, complements, tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, sIL-6R (soluble IL-6 receptor), ICTP (C-terminal telopeptide of type I collagen), and PINP (N-terminal propeptide of type I procollagen). Simple and multiple regression analyses as well as logistic regression analyses were performed. Resistin in serum was compared with 42 healthy female controls with respect to age. Serum resistin levels in controls were similar to those of patients with SLE. Markers of inflammation and current dose of glucocorticosteroids correlated positively to resistin in serum. Markers of renal function, number of prevalent vertebral fractures, and BMD were also significantly associated with resistin. In a multiple regression model, ESR, creatinine, C3, current glucocorticosteroid dose, high-density lipoprotein, and BMD radius remained significantly associated with resistin. In logistic regression analyses with resistin as the independent variable, a significant association was found with ESR (normal or elevated) but not with S-creatinine or z score for hip and radius total. Although resistin measurements did not differ between patients and controls, resistin was clearly associated with general inflammation, renal disease, treatment with glucocorticosteroids, and bone loss. We hypothesize that resistin has proinflammatory and disease-promoting properties in SLE. Further studies are needed to elucidate the mechanism behind these associations.
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         Systemic Lupus Erythematosus
         Glomerular Filtration Rate
         Erythrocyte Sedimentation Rate
         Vertebral Compression Fracture
         Rheumatology
         Orthopedics
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