We are analyzing https://link.springer.com/article/10.1186/ar2095.

Title:
Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus | Arthritis Research & Therapy
Description:
Infection imposes a serious burden on patients with systemic lupus erythematosus (SLE). The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently, the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in SLE. In previous studies, SLE patients homozygous for mannose-binding lectin (MBL) variant alleles were at an increased risk of acquiring serious infections in comparison with patients who were heterozygous or homozygous for the normal allele. This association suggests a correlation between functional MBL level and occurrence of infections in SLE patients. We therefore investigated the biological activity of MBL and its relationship with the occurrence of infections in patients with SLE. Demographic and clinical data were collected in 103 patients with SLE. Functional MBL serum levels and MBL-induced C4 deposition were measured by enzyme-linked immunosorbent assay using mannan as coat and an MBL- or C4b-specific monoclonal antibody. The complete MBL-dependent pathway activity was determined by using an assay that measures the complete MBL pathway activity in serum, starting with binding of MBL to mannan, and was detected with a specific monoclonal antibody against C5b-9. Charts were systematically reviewed to obtain information on documented infections since diagnosis of SLE. Major infections were defined as infections requiring hospital admission and intravenous administration of antibiotics. In total, 115 infections since diagnosis of lupus, including 42 major infections, were documented in the 103 SLE patients (mean age 41 ± 13 years, mean disease duration 7 ± 4 years). The percentage of SLE patients with severe MBL deficiency was similar to that in 100 healthy controls: 13% versus 14%, respectively. Although deposition of C4 to mannan and MBL pathway activity were reduced in 21% and 43% of 103 SLE patients, respectively, neither functional MBL serum levels nor MBL pathway activity was associated with infections or major infections in regression analyses. In conclusion, SLE patients frequently suffer from infections, but deficiency of functional MBL does not confer additional risk.
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Keywords {🔍}

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Topics {✒️}

ben ac dijkmans & alexandre ben ac dijkmans irene em bultink tris-buffered saline/ca2+/milk enzyme-linked immunosorbent assay article download pdf membrane-attack complex c5–9 functional mannose-binding lectin previous lupus nephritis systemic lupus erythematosus polymerised streptavidin-horseradish peroxidase mannose-binding lectin deficiency mannose-binding lectin polymorphisms lupus nephritis confirmed mannose-binding lectin dysfunction mbl-induced c4 deposition mbl-induced complement activity mbl-specific monoclonal antibody statens serum institute article bultink c4b-specific monoclonal antibody privacy choices/manage cookies authors’ original file mannose-binding lectin = mannose-binding lectin mannose binding lectin clinics provide primary infectious episode infectious complications occur multiple regression analyses full access multiple regression models single patient ranged article number r183 full genotypic characterisation organ damage index turner mw severely decreased activity hopkins lupus cohort decreased functional activity multiple regression analysis functional mbl level median functional activity disease activity index 2% gelatin [wt/vol] c-type lectin carbohydrate-binding domain mbl serum levels european economic area blood bank donors

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WebPage:
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         headline:Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus
         description:Infection imposes a serious burden on patients with systemic lupus erythematosus (SLE). The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently, the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in SLE. In previous studies, SLE patients homozygous for mannose-binding lectin (MBL) variant alleles were at an increased risk of acquiring serious infections in comparison with patients who were heterozygous or homozygous for the normal allele. This association suggests a correlation between functional MBL level and occurrence of infections in SLE patients. We therefore investigated the biological activity of MBL and its relationship with the occurrence of infections in patients with SLE. Demographic and clinical data were collected in 103 patients with SLE. Functional MBL serum levels and MBL-induced C4 deposition were measured by enzyme-linked immunosorbent assay using mannan as coat and an MBL- or C4b-specific monoclonal antibody. The complete MBL-dependent pathway activity was determined by using an assay that measures the complete MBL pathway activity in serum, starting with binding of MBL to mannan, and was detected with a specific monoclonal antibody against C5b-9. Charts were systematically reviewed to obtain information on documented infections since diagnosis of SLE. Major infections were defined as infections requiring hospital admission and intravenous administration of antibiotics. In total, 115 infections since diagnosis of lupus, including 42 major infections, were documented in the 103 SLE patients (mean age 41 ± 13 years, mean disease duration 7 ± 4 years). The percentage of SLE patients with severe MBL deficiency was similar to that in 100 healthy controls: 13% versus 14%, respectively. Although deposition of C4 to mannan and MBL pathway activity were reduced in 21% and 43% of 103 SLE patients, respectively, neither functional MBL serum levels nor MBL pathway activity was associated with infections or major infections in regression analyses. In conclusion, SLE patients frequently suffer from infections, but deficiency of functional MBL does not confer additional risk.
         datePublished:2006-12-13T00:00:00Z
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            Hydroxychloroquine
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            Infectious Episode
            Rheumatology
            Orthopedics
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ScholarlyArticle:
      headline:Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus
      description:Infection imposes a serious burden on patients with systemic lupus erythematosus (SLE). The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently, the lectin pathway of complement activation has also been suggested to play a role in the occurrence of infections in SLE. In previous studies, SLE patients homozygous for mannose-binding lectin (MBL) variant alleles were at an increased risk of acquiring serious infections in comparison with patients who were heterozygous or homozygous for the normal allele. This association suggests a correlation between functional MBL level and occurrence of infections in SLE patients. We therefore investigated the biological activity of MBL and its relationship with the occurrence of infections in patients with SLE. Demographic and clinical data were collected in 103 patients with SLE. Functional MBL serum levels and MBL-induced C4 deposition were measured by enzyme-linked immunosorbent assay using mannan as coat and an MBL- or C4b-specific monoclonal antibody. The complete MBL-dependent pathway activity was determined by using an assay that measures the complete MBL pathway activity in serum, starting with binding of MBL to mannan, and was detected with a specific monoclonal antibody against C5b-9. Charts were systematically reviewed to obtain information on documented infections since diagnosis of SLE. Major infections were defined as infections requiring hospital admission and intravenous administration of antibiotics. In total, 115 infections since diagnosis of lupus, including 42 major infections, were documented in the 103 SLE patients (mean age 41 ± 13 years, mean disease duration 7 ± 4 years). The percentage of SLE patients with severe MBL deficiency was similar to that in 100 healthy controls: 13% versus 14%, respectively. Although deposition of C4 to mannan and MBL pathway activity were reduced in 21% and 43% of 103 SLE patients, respectively, neither functional MBL serum levels nor MBL pathway activity was associated with infections or major infections in regression analyses. In conclusion, SLE patients frequently suffer from infections, but deficiency of functional MBL does not confer additional risk.
      datePublished:2006-12-13T00:00:00Z
      dateModified:2006-12-13T00:00:00Z
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         Systemic Lupus Erythematosus
         Systemic Lupus Erythematosus Patient
         Hydroxychloroquine
         Major Infection
         Infectious Episode
         Rheumatology
         Orthopedics
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      name:Sanquin Research at CLB, Amsterdam, The Netherlands
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      name:Slotervaart Hospital, Amsterdam, The Netherlands
      name:Jan van Breemen Institute, Amsterdam, The Netherlands
      name:Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands

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