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pubmed, article, google, scholar, nanocarriers, cas, drug, delivery, targeting, ecs, central, nanoparticles, endothelial, vascular, cells, targeted, therapeutic, cell, surface, size, nanocarrier, diseases, strategies, therapy, efficacy, zhang, interactions, release, blood, fig, wang, brain, barrier, endothelium, potential, nanomedicine, target, tumor, system, treatment, adhesion, specific, injury, cancer, adv, research, disease, uptake, enhance, efficiency,

Topics {✒️}

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Questions {❓}

• How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
• Targeting therapeutics to endothelium: are we there yet?

Schema {🗺️}

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         headline:Nanocarriers for targeted drug delivery in the vascular system: focus on endothelium
         description:Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics, and modulating inflammatory responses. Nanocarriers hold transformative potential for precise drug delivery within the vascular system, particularly targeting ECs for therapeutic purposes. However, the complex interactions between vascular ECs and nanocarriers present significant challenges for the development and clinical translation of nanotherapeutics. This review assesses recent advancements and key strategies in employing nanocarriers for drug delivery to vascular ECs. It suggested that through precise physicochemical design and surface modifications, nanocarriers can enhance targeting specificity and improve drug internalization efficiency in ECs. Additionally, we elaborated on the applications of nanocarriers specifically designed for targeting ECs in the treatment of cardiovascular diseases, cancer metastasis, and inflammatory disorders. Despite these advancements, safety concerns, the complexity of in vivo processes, and the challenge of achieving subcellular drug delivery remain significant obstacles to the effective targeting of ECs with nanocarriers. A comprehensive understanding of endothelial cell biology and its interaction with nanocarriers is crucial for realizing the full potential of targeted drug delivery systems.
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            name:Jilin University
            address:
               name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
               type:PostalAddress
            type:Organization
            name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases
            address:
               name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Tianmeng Sun
      affiliation:
            name:Jilin University
            address:
               name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
               type:PostalAddress
            type:Organization
            name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases
            address:
               name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
               type:PostalAddress
            type:Organization
            name:Jilin University
            address:
               name:International Center of Future Science, Jilin University, Changchun, China
               type:PostalAddress
            type:Organization
            name:Jilin University
            address:
               name:State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China
               type:PostalAddress
            type:Organization
            name:Chinese PLA General Hospital
            address:
               name:State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
      name:International Center of Future Science, Jilin University, Changchun, China
      name:State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
      name:Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital, Jilin University, Changchun, China
      name:National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, China
      name:International Center of Future Science, Jilin University, Changchun, China
      name:State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China
      name:State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China

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