We are analyzing https://link.springer.com/article/10.1186/2045-8118-9-14.

Title:
Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands | Fluids and Barriers of the CNS
Description:
Background Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis. Findings Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio. Conclusion Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
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Keywords {🔍}

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Topics {✒️}

qigg[spec]=iggspec[csf]/iggspec[serum] qigg[total]=iggtotal[csf]/iggtotal[serum][1 qigg = csf/serum total-igg ratio varicella zoster virus total-igg oligoclonal bands virus-specific oligoclonal igg herpes simplex virus antigen-specific oligoclonal bands stiff person syndrome intrathecal total-igg synthesis csf/serum total-igm ratios termed mrz reaction qalb = csf/serum albumin ratio automated database search ri specific igg-synthesis antigen-specific igg synthesis ai=qigg[spec]/qigg[total] total-igg ocb-negative patients antibody index assessment herpes simplex blisters mrz reaction oligoclonal igg-bands restricted oligoclonal bands csf/serum albumin ratios negative total-igg ocb paired csf/serum sample total-igg ocb detection antigen-specific ocbs compared total-igg ocb testing negative total-igg ocbs central nervous system multiple sclerosis patients individual csf/serum ratios total-igg ocb positivity total-igg ocbs detection borrelia burgdorferi article download pdf bacterium-specific igg-ais preclude false-positive results ai=qigg[spec]/qlim false-negative ocb result anti-cv2/crmp5 mumps-specific bands anti-igg immunofixation multiple sclerosis” multiple sclerosis cerebrospinal fluid–physiology cerebrospinal fluid res oligoclonal bands measles virus

Schema {🗺️}

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         headline:Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands
         description:Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis. Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio. Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
         datePublished:2012-07-31T00:00:00Z
         dateModified:2012-07-31T00:00:00Z
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            Intrathecal IgG synthesis
            Antibody index
            Cerebrospinal fluid
            Oligoclonal bands
            Herpes simplex virus
            Cytomegalovirus
            Varicella zoster virus
            Measles virus
            Rubella virus
            Borrelia burgdorferi
            Multiple sclerosis
            MRZ reaction
            Neurosciences
            Hematology
            Neurobiology
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ScholarlyArticle:
      headline:Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands
      description:Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis. Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio. Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
      datePublished:2012-07-31T00:00:00Z
      dateModified:2012-07-31T00:00:00Z
      pageStart:1
      pageEnd:5
      license:http://creativecommons.org/licenses/by/2.0
      sameAs:https://doi.org/10.1186/2045-8118-9-14
      keywords:
         Intrathecal IgG synthesis
         Antibody index
         Cerebrospinal fluid
         Oligoclonal bands
         Herpes simplex virus
         Cytomegalovirus
         Varicella zoster virus
         Measles virus
         Rubella virus
         Borrelia burgdorferi
         Multiple sclerosis
         MRZ reaction
         Neurosciences
         Hematology
         Neurobiology
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            name:Brigitte Wildemann
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      email:[email protected]
      name:Peter Eichhorn
      affiliation:
            name:Ludwig Maximilian University
            address:
               name:Department of Clinical Chemistry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
               type:PostalAddress
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      name:Brigitte Wildemann
      affiliation:
            name:University of Heidelberg
            address:
               name:Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Manfred Wick
      affiliation:
            name:Ludwig Maximilian University
            address:
               name:Department of Clinical Chemistry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
               type:PostalAddress
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      name:Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
      name:Department of Clinical Chemistry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
      name:Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
      name:Department of Clinical Chemistry, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany

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