We are analyzing https://link.springer.com/article/10.1186/2045-8118-11-10.

Title:
A new look at cerebrospinal fluid circulation | Fluids and Barriers of the CNS
Description:
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid space to be absorbed into the blood by the arachnoid villi. This review surveys key developments leading to the traditional concept. Challenging this concept are novel insights utilizing molecular and cellular biology as well as neuroimaging, which indicate that CSF physiology may be much more complex than previously believed. The CSF circulation comprises not only a directed flow of CSF, but in addition a pulsatile to and fro movement throughout the entire brain with local fluid exchange between blood, interstitial fluid, and CSF. Astrocytes, aquaporins, and other membrane transporters are key elements in brain water and CSF homeostasis. A continuous bidirectional fluid exchange at the blood brain barrier produces flow rates, which exceed the choroidal CSF production rate by far. The CSF circulation around blood vessels penetrating from the subarachnoid space into the Virchow Robin spaces provides both a drainage pathway for the clearance of waste molecules from the brain and a site for the interaction of the systemic immune system with that of the brain. Important physiological functions, for example the regeneration of the brain during sleep, may depend on CSF circulation.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

csf, pubmed, google, scholar, brain, fluid, cas, water, flow, cerebrospinal, space, aqp, blood, vrs, central, rate, drainage, absorption, subarachnoid, cerebral, circulation, choroid, barrier, perivascular, plexus, spaces, physiology, experiments, isf, pressure, formation, aquaporin, production, transport, mice, interstitial, studies, pial, understanding, hydrocephalus, membranes, ventricles, aquaporins, system, cells, cell, movement, membrane, findings, arteries,

Topics {✒️}

john morrison & petra klinge magnetic resonance measurement phase contrast–normal values advanced phase-contrast mri phase-contrast mr studies related subjects central nervous system full size image dystrophin-null transgenic mice fluid-filled open space single-layered choroidal epithelium phase contrast sequences open access license deuterium oxide half-life aqp4-null mice strains mr velocity imaging blood-cerebrospinal fluid barrier systemic hypo-osmotic stress carbon-labeled perivascular cells high-resolution immunogold cytochemistry pressure-sensitive vacuolation cycle mice lacking alpha-syntrophin article download pdf single-cell layered structure[75] full access investigating aqp4-deficient mice extracorporally-perfused choroid plexus[19–22] privacy choices/manage cookies blood–brain barrier structure para-arterial drainage pathways contrast-enhanced mri video-densitometric measurements mr imaging systems acute water intoxication peri-arterial drainage pathways[83] transcellular water flow cerebrospinal fluid system dystrophin-null mice[134] virchow robin space virchow-robin space[66 author information authors flow rates ranging weed inadvertently excluded apparently continuous layer literature review presenting bi-directional exchange systemic immune system additional barrier surrounding transcellular bulk transport choroidal epithelium forms

Questions {❓}

Bateman GA, Brown KM: The measurement of CSF flow through the aqueduct in normal and hydrocephalic children: from where does it come, to where does it go?
Bechmann I, Galea I, Perry VH: What is the blood–brain barrier (not)?
Ge S, Song L, Pachter JS: Where is the blood–brain barrier … really?
Oreskovic D, Klarica M, Vukic M: The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion?

Schema {🗺️}

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