We are analyzing https://link.springer.com/article/10.1186/1756-9966-30-87.

Title:
Apoptosis in cancer: from pathogenesis to treatment | Journal of Experimental & Clinical Cancer Research
Description:
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.
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Keywords {🔍}

apoptosis, google, scholar, cancer, pubmed, article, cells, cas, cell, death, proteins, bcl, caspase, gene, targeting, treatment, caspases, therapy, pathway, survivin, tumour, human, expression, central, antiapoptotic, clinical, protein, family, pathways, drugs, apoptotic, resistance, receptor, reported, target, molecules, xiap, proapoptotic, patients, inhibitor, drug, res, cellular, carcinogenesis, role, strategies, found, growth, include, activation,

Topics {✒️}

p53-peptide-pulsed dendritic cells e1b-55kd gene-deleted adenovirus pro-apoptotic drug r-etodolac tnf-related apoptosis-inducing ligand rebecca sy wong long peptide-based vaccines ligand-receptor-adaptor protein complex including short peptide-based arginin-glycine-aspartate motif mdm2-p53 protein-protein interaction article download pdf n-terminal deletion mutant wolters kluwer/lippincott williams dendritic-cell based vaccines wild-type p53 gene human wild-type p53 generating p53-specific cytotoxic overcomes growth arrest/senescence p53-based gene therapy primary patient-derived cells human b-cell lymphomas cyclin-dependent kinase inhibitors death-inducing signalling complex caspase-based gene therapy small-molecule p53 activator multi-drug resistance phenotype caspase-based drug therapy viral-based vaccines eliminate p53-deficient cells human iap-family gene exert anti-cancer effects inhibits anti-apoptotic proteins adenovirus-mediated transfer short interfering rna o'brien sm p53-rescue drug cp-31398 article wong suppress survivin expression privacy choices/manage cookies caspase-3-deficient breast cancer anti-apoptotic proteins/genes upregulated anti-apoptotic proteins wild-type functions authors’ original file pro-apoptotic effects observed pro-apoptotic proteins act aggressive tumor spectrum endoplasmic reticulum stress tumour suppressor gene chronic lymphocytic leukaemia

Questions {❓}

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?

Schema {🗺️}

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         headline:Apoptosis in cancer: from pathogenesis to treatment
         description:Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.
         datePublished:2011-09-26T00:00:00Z
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      headline:Apoptosis in cancer: from pathogenesis to treatment
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         treatment target
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         Oncology
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