We are analyzing https://link.springer.com/article/10.1186/1755-1536-5-s1-s24.

Title:
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis | Fibrogenesis & Tissue Repair
Description:
CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the literature that inhibition of CTGF expression by siRNA prevents CCl4-induced liver fibrosis and can reverse fibrosis when administered after significant collagen deposition is observed. A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. When FG-3019 was administered to mice after a significant radiation-induced increase in lung density could be observed by CT imaging, the density of the lungs was observed to decrease over the period during which the antibody was administered and to remain stable after therapy had ceased. When considered together, these data indicate that inhibition of CTGF can prevent and reverse the process of fibrosis.
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Keywords {🔍}

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Topics {✒️}

transforming growth factor-beta connective-tissue growth factor idiopathic pulmonary fibrosis pancreatic tumor growth modulates cell signalling radiation-induced pulmonary fibrosis targeted sirna therapy traditional growth factor article download pdf α-smooth muscle actin article number s24 anti-fibrotic regulatory pathway bone-marrow-derived fibrosis-related gene transcripts bone morphogenetic protein-7 human anti-ctgf antibodies cysteine-rich mitogen secreted axial stiffness continued radiation-induced lung fibrosis ccl4-induced liver fibrosis inhibits vegf-induced angiogenesis positive feedback loops significant radiation-induced increase secreted matricellular protein sciencell research laboratories positive feedback loop mouse fibrosis model orthotopic mouse model defined growth supplements signaling pathways leading monoclonal antibody privacy choices/manage cookies /supplements/5/s1 signal transduction pathways radiation-induced model axial stiffness extracellular adapter protein intracellular adapter protein human liver fibrosis tissue repair tissue remodeling occurs cell commun signal de robertis em pancreatic ductal adenocarcinoma targeted therapies competing interests matricellular protein full size image promotes fibroblast adhesion stimulating signal transduction

Questions {❓}

Oliver N, Sternlicht M, Gerritsen K, Goldschmeding R: Could aging human skin use a connective tissue growth factor boost to increase collagen content?

Schema {🗺️}

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         description:CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the literature that inhibition of CTGF expression by siRNA prevents CCl4-induced liver fibrosis and can reverse fibrosis when administered after significant collagen deposition is observed. A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. When FG-3019 was administered to mice after a significant radiation-induced increase in lung density could be observed by CT imaging, the density of the lungs was observed to decrease over the period during which the antibody was administered and to remain stable after therapy had ceased. When considered together, these data indicate that inhibition of CTGF can prevent and reverse the process of fibrosis.
         datePublished:2012-06-06T00:00:00Z
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            Tissue Remodel
            Axial Stiffness
            Matricellular Protein
            Internal Medicine
            Cell Biology
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      headline:CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
      description:CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the literature that inhibition of CTGF expression by siRNA prevents CCl4-induced liver fibrosis and can reverse fibrosis when administered after significant collagen deposition is observed. A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. When FG-3019 was administered to mice after a significant radiation-induced increase in lung density could be observed by CT imaging, the density of the lungs was observed to decrease over the period during which the antibody was administered and to remain stable after therapy had ceased. When considered together, these data indicate that inhibition of CTGF can prevent and reverse the process of fibrosis.
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         Connective Tissue Growth Factor
         Tissue Remodel
         Axial Stiffness
         Matricellular Protein
         Internal Medicine
         Cell Biology
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