We are analyzing https://link.springer.com/article/10.1186/1750-1326-3-18.

Title:
NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression | Molecular Neurodegeneration
Description:
Background Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4th commonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action potential and respond to some pathological stimuli, but the function of the cells is still unclear. We assumed the NG2 cells may play an active role in neuropathogenesis and aimed to determine if NG2 cells could sense and response to the alterations in the axonal contents caused by disruption of neurofilament light subunit (NFL) expression. Results In the early neuropathological development stage, our study showed that the diameter of axons of upper motor neurons of NFL-/- mice decreased significantly while the thickness of their myelin sheath increased remarkably. Although there was an obvious morphological distortion in axons with occasionally partial demyelination, no obvious changes in expression of myelin proteins was detected. Parallel to these changes in the axons and their myelination, the processes of NG2 cells were disconnected from the nodes of Ranvier and extended further, suggesting that these cells in the spinal cord white matter could sense the alteration in axonal contents caused by disruption of NFL expression before astrocytic and microglial activation. Conclusion The structural configuration determined by the NFL gene may be important for maintenance of normal morphology of myelinated axons. The NG2 cells might serve as an early sensor for the delivery of information from impaired neurons to the local environment.
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Keywords {🔍}

mice, nfl, cells, axons, spinal, cord, axonal, article, pubmed, age, cell, google, scholar, myelin, type, months, matter, white, neurons, wild, figure, cas, expression, processes, myelinated, fig, number, brain, usa, authors, ranvier, sections, sheath, neurofilament, neuronal, significant, size, original, thickness, axon, full, study, protein, increase, animals, disruption, diameter, node, glial, nfh,

Topics {✒️}

amyotrophic lateral sclerosis ng2 chondroitin-sulfate proteoglycan neurofilament-beta-galactosidase fusion protein cy3-conjugated anti-rabbit goat anti-rabbit igg open access article article download pdf cu/zn superoxide dismutase anti-rat secondary antibody stem cell technology kainate-lesioned rat hippocampus intact unique k-na aggregate-bearing neurons begins tris-glycine-methanol buffer ng2-expressing oligodendrocyte progenitors bio-rad protein assay bowknot shaped k-na periaxonal schwann cell zhi cheng xiao authors’ original file central nervous system wild type mouse privacy choices/manage cookies full size image glial precursor cells mouse anti-cnpase ya fang tang article wu neurofilament light subunit brain injury models glial cell population unique k-na positive double labelling neurofilament heavy subunit heavy neurofilament subunit glial cell type ng2-deficient mouse retarded microglial transformation c57bl/6 background [24] small cell bodies small cell body electron micrographs show cell surface antigen schwann cells mouse monoclonal antibody ng2 positive cells comparing wild type multiple sclerosis vectashield mounting medium 5% goat serum/pbs

Questions {❓}

Dawson MR, Levine JM, Reynolds R: NG2-expressing cells in the central nervous system: Are they oligodendroglial progenitors?

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         headline:NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression
         description:Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4th commonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action potential and respond to some pathological stimuli, but the function of the cells is still unclear. We assumed the NG2 cells may play an active role in neuropathogenesis and aimed to determine if NG2 cells could sense and response to the alterations in the axonal contents caused by disruption of neurofilament light subunit (NFL) expression. In the early neuropathological development stage, our study showed that the diameter of axons of upper motor neurons of NFL-/- mice decreased significantly while the thickness of their myelin sheath increased remarkably. Although there was an obvious morphological distortion in axons with occasionally partial demyelination, no obvious changes in expression of myelin proteins was detected. Parallel to these changes in the axons and their myelination, the processes of NG2 cells were disconnected from the nodes of Ranvier and extended further, suggesting that these cells in the spinal cord white matter could sense the alteration in axonal contents caused by disruption of NFL expression before astrocytic and microglial activation. The structural configuration determined by the NFL gene may be important for maintenance of normal morphology of myelinated axons. The NG2 cells might serve as an early sensor for the delivery of information from impaired neurons to the local environment.
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            Amyotrophic Lateral Sclerosis
            Wild Type Mouse
            Myelin Sheath
            Corticospinal Tract
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            Molecular Medicine
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      headline:NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression
      description:Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4th commonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action potential and respond to some pathological stimuli, but the function of the cells is still unclear. We assumed the NG2 cells may play an active role in neuropathogenesis and aimed to determine if NG2 cells could sense and response to the alterations in the axonal contents caused by disruption of neurofilament light subunit (NFL) expression. In the early neuropathological development stage, our study showed that the diameter of axons of upper motor neurons of NFL-/- mice decreased significantly while the thickness of their myelin sheath increased remarkably. Although there was an obvious morphological distortion in axons with occasionally partial demyelination, no obvious changes in expression of myelin proteins was detected. Parallel to these changes in the axons and their myelination, the processes of NG2 cells were disconnected from the nodes of Ranvier and extended further, suggesting that these cells in the spinal cord white matter could sense the alteration in axonal contents caused by disruption of NFL expression before astrocytic and microglial activation. The structural configuration determined by the NFL gene may be important for maintenance of normal morphology of myelinated axons. The NG2 cells might serve as an early sensor for the delivery of information from impaired neurons to the local environment.
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         Amyotrophic Lateral Sclerosis
         Wild Type Mouse
         Myelin Sheath
         Corticospinal Tract
         Neurosciences
         Neurology
         Molecular Medicine
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      name:Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
      name:Department of Clinical Research, Singapore General Hospital, Singapore
      name:Division of Life Science and Technology, Ocean University of China, Qingdao, PR China
      name:Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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