We are analyzing https://link.springer.com/article/10.1186/1743-7075-9-47.

Title:
DHEA administration and exercise training improves insulin resistance in obese rats | Nutrition & Metabolism
Description:
Background Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This study was undertaken to determine whether 6-weeks of DHEA administration and/or exercise training improve insulin resistance in obese male rats. Methods After 14 weeks of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of four groups: control, DHEA administration, exercise training, and a combination of DHEA administration and exercise training (n = 10 each group). Results After 6-weeks of DHEA administration and/or exercise training, rats in the combination group weighed significantly less and had lower serum insulin levels than rats in the other groups. Moreover, the rats treated with DHEA alone or DHEA and exercise had significantly lower fasting glucose levels (combination, 84 ± 6.5 mg/dL; DHEA, 102 ± 9.5 mg/dL; control, 148 ± 10.5 mg/dL). In addition, insulin sensitivity check index showed significant improvements in the combination group (combination, 0.347 ± 0.11; exercise, 0.337 ± 0.16%; DHEA, 0.331 ± 0.14; control, 0.308 ± 0.12). Muscular DHEA and 5α-dihydrotestosterone (DHT) concentrations were significantly higher in the combination group, and closely correlated with the quantitative insulin-sensitivity check index (DHEA: r = 0.71, p < 0.01; DHT: r = 0.69, p < 0.01). Conclusion These results showed that a combination of DHEA administration and exercise training effectively improved fasting blood glucose and insulin levels, and insulin sensitivity, which may reflect increased muscular DHEA and DHT concentrations.
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Topics {✒️}

long-chain fatty acyl-coenzyme secondary horseradish-peroxidase-coupled antibodies pkc ζ/λ-glut4 pathway akt/pkcζ/λ activity open access article ampk-pgc-1α-nrf-1 fasting-induced hepatic production fatty acid metabolism sex steroid hormone voluntary running-wheel training dhea enhanced glut-4-relatedsignaling muscular steroidogenesis-related enzymes post-hoc comparison test insulin-stimulated glucose uptake article download pdf metabolic syndrome purified high-sucrose diet short-term exercise training diet-induced obese rats 1 mg/kg body weight short-term dhea intake growth hormone administration sex steroid hormones short-term dhea administration privacy choices/manage cookies streptozotocin-induced diabetes rats satoshi fujita increasing insulin sensitivity authors’ original file epididymal fat weight improve insulin resistance steroidogenesis-related enzymes [5 diet-induced obesity fat increase gluconeogenesis basal glucose production assessing insulin sensitivity insulin resistance related high-fat diet insulin-induced inhibition insulin resistance induced immobilized polyclonal antibodies reduces adipocyte hyperplasia blood glucose meter full access age-related decline enhanced insulin sensitivity blood glucose levels serum insulin levels decrease food intake wheel-running exercise

Questions {❓}

Berdanier CD, Parente JA, McIntosh MK: Is dehydroepiandrosterone an antiobesity agent?

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WebPage:
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         headline:DHEA administration and exercise training improves insulin resistance in obese rats
         description:Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This study was undertaken to determine whether 6-weeks of DHEA administration and/or exercise training improve insulin resistance in obese male rats. After 14 weeks of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of four groups: control, DHEA administration, exercise training, and a combination of DHEA administration and exercise training (n = 10 each group). After 6-weeks of DHEA administration and/or exercise training, rats in the combination group weighed significantly less and had lower serum insulin levels than rats in the other groups. Moreover, the rats treated with DHEA alone or DHEA and exercise had significantly lower fasting glucose levels (combination, 84 ± 6.5 mg/dL; DHEA, 102 ± 9.5 mg/dL; control, 148 ± 10.5 mg/dL). In addition, insulin sensitivity check index showed significant improvements in the combination group (combination, 0.347 ± 0.11; exercise, 0.337 ± 0.16%; DHEA, 0.331 ± 0.14; control, 0.308 ± 0.12). Muscular DHEA and 5α-dihydrotestosterone (DHT) concentrations were significantly higher in the combination group, and closely correlated with the quantitative insulin-sensitivity check index (DHEA: r = 0.71, p < 0.01; DHT: r = 0.69, p < 0.01). These results showed that a combination of DHEA administration and exercise training effectively improved fasting blood glucose and insulin levels, and insulin sensitivity, which may reflect increased muscular DHEA and DHT concentrations.
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      headline:DHEA administration and exercise training improves insulin resistance in obese rats
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         Metabolic Diseases
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