We are analyzing https://link.springer.com/article/10.1186/1479-5876-12-125.

Title:
Subsets of regulatory T cells and their roles in allergy | Journal of Translational Medicine
Description:
In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth, Tregs likely play key roles in the pathogenesis of allergy, particularly during the sensitization phase. However, accumulated information indicate that there are several distinctive subtypes of Tregs in man, and each of them seems to play different role in controlling immune system, which complicates the involvement of Tregs in allergy. The aim of the present study is to attempt to classify subtypes of Tregs and summarize their roles in allergy. Tregs should include natural Tregs (nTreg) including inducible costimulator (ICOS)(+) Tregs, inducible/adaptive Tregs (iTreg), interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), CD8(+) Tregs and IL-17-producing Tregs. These cells share some common features including expression of Foxp3 (except for Tr1 cells), and secretion of inhibitory cytokine IL-10 and/or TGF-β. Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. Modulation of functions of Tregs may provide a novel strategy to prevent and treat allergic diseases.
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Keywords {🔍}

cells, tregs, article, pubmed, scholar, allergic, google, regulatory, allergy, cell, foxp, immunol, inflammation, treg, expression, immune, tgfβ, airway, asthma, effector, mast, tolerance, diseases, responses, central, production, function, role, suppression, development, immunotherapy, allergens, sensitization, mice, mechanisms, disease, induced, clin, treatment, including, phase, ilproducing, itregs, suppressive, subsets, differentiation, naive, suppress, induction, found,

Topics {✒️}

direct t-cell-t-cell interaction jnk = jun n-terminal kinase jak = janus-family tyrosine kinase nf-κb/p65 nuclear translocation cell membrane-bound tgf-β membrane-bound tgf-β expressed regulate nf-κb/p65 expression antigen-specific t-cell anergy coli heat-labile enterotoxin nfkb = nuclear factor kappa surface-bound tgf-beta tgf-β1-induced-expressing itregs reduces ova-specific ige transforming growth factor nitric oxide-induced regulatory ox40/ox40 ligand interactions cytokine-induced il-10-secreting cd8 antagonizes t-cell-receptor smad = small body size inhibit ifn-γ synthesis rar = retinoic acid receptor antigen-induced airway hyperreactivity anti-il-2 mab reduce anti-il-10 receptor antibody granzyme-perforin-induced apoptosis il-4ralpha-stat6 axis successful allergen-specific immunotherapy peripheral t-cell tolerance highly suppressive antigen-specific foxp3 = forkhead box p3 t-cell receptor stimulation allergen-exposed skin area article download pdf decreased nf-kappab expression suppressive cytokines tgf-beta skin-draining lymph nodes monocyte-derived immunomodulation dcs long-term aerosol challenge t-cell regulatory mechanisms ifn-gamma-secreting th1 inhibit th1-cell differentiation unique cell-surface phenotype regulatory t-cell control th2 cell-driven response il-4/il-5-secreting th2 th17-driven lung inflammation cd103+ effector/memory tregs antigen-specific induced investigated allergen-induced th2 functional allergen-specific tregs

Questions {❓}

Jutel M, Akdis M, Blaser K, Akdis CA: Are regulatory T cells the target of venom immunotherapy?
Ziora D, Sitek P, Machura E, Ziora K: Bronchial asthma in obesity–a distinct phenotype of asthma?

Schema {🗺️}

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         headline:Subsets of regulatory T cells and their roles in allergy
         description:In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth, Tregs likely play key roles in the pathogenesis of allergy, particularly during the sensitization phase. However, accumulated information indicate that there are several distinctive subtypes of Tregs in man, and each of them seems to play different role in controlling immune system, which complicates the involvement of Tregs in allergy. The aim of the present study is to attempt to classify subtypes of Tregs and summarize their roles in allergy. Tregs should include natural Tregs (nTreg) including inducible costimulator (ICOS)(+) Tregs, inducible/adaptive Tregs (iTreg), interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), CD8(+) Tregs and IL-17-producing Tregs. These cells share some common features including expression of Foxp3 (except for Tr1 cells), and secretion of inhibitory cytokine IL-10 and/or TGF-β. Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. Modulation of functions of Tregs may provide a novel strategy to prevent and treat allergic diseases.
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      headline:Subsets of regulatory T cells and their roles in allergy
      description:In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth, Tregs likely play key roles in the pathogenesis of allergy, particularly during the sensitization phase. However, accumulated information indicate that there are several distinctive subtypes of Tregs in man, and each of them seems to play different role in controlling immune system, which complicates the involvement of Tregs in allergy. The aim of the present study is to attempt to classify subtypes of Tregs and summarize their roles in allergy. Tregs should include natural Tregs (nTreg) including inducible costimulator (ICOS)(+) Tregs, inducible/adaptive Tregs (iTreg), interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), CD8(+) Tregs and IL-17-producing Tregs. These cells share some common features including expression of Foxp3 (except for Tr1 cells), and secretion of inhibitory cytokine IL-10 and/or TGF-β. Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. Modulation of functions of Tregs may provide a novel strategy to prevent and treat allergic diseases.
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