We are analyzing https://link.springer.com/article/10.1186/1477-7827-10-49.

Title:
The effects of oxidative stress on female reproduction: a review | Reproductive Biology and Endocrinology
Description:
Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.
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Topics {✒️}

gov/pacific/ecoservices/envicon/pim/reports/contaminantinfo/contaminants amani shaman & sajal gupta c-jun n-terminal kinases ethylenediamine tetra-acetic acid 8-iso-pgf2-alpha promotes necrosis store-operated calcium entry advanced glycation end-products biomarker 8-iso-prostaglandin f2-alpha ortiz-de-galisteo jr intra-uterine growth retardation article download pdf low-grade long-term exposure methyl-tetra-hydrofolate reductase springer science+business media nhlbi working group thiobarbituric acid-reactive substances fisher-wellman kh centrally-stored fat deposits inhibitory subunit i-kappa capacitative calcium entry endothelium-derived nitric oxide materno-fetal oxygen gradient post-operative adhesion formation de la jara-diaz oxidized low-density lipoprotein randomised placebo-controlled trial glutathione s-transferase m1 central fat storage tumor necrosis factor-alpha transcription factor nf-kappa free radical-mediated embryopathies pesticide-induced oxidative stress hla-drb103 risk allele mitogen-activated protein kinases impaired endothelium-dependent vasodilation enzymes γ-glutamylcysteine synthetase 8-iso-pgf2-alpha levels higher age-group preeclamptic abbreviations 8-iso-pgf2-alpha forms stable end-products vitro ischemia-reperfusion injury redox-sensitive molecular targets nitric oxide synthase human fetal-maternal interface national academies press dose-related adverse effects delicate oxidant/antioxidant balance ask1-map kinase pathway nitric oxide-mediated pathogenesis linking placental ischemia/hypoxia

Questions {❓}

Combelles CM, Gupta S, Agarwal A: Could oxidative stress influence the in-vitro maturation of oocytes?
Cummins JM, Jequier AM, Kan R: Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress?
Halliwell B: Effect of diet on cancer development: is oxidative DNA damage a biomarker?
Haslbeck KM, Neundorfer B, Schlotzer-Schrehardtt U, Bierhaus A, Schleicher E, Pauli E, Haslbeck M, Hecht M, Nawroth P, Heuss D: Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?
Murphy AA, Santanam N, Parthasarathy S: Endometriosis: a disease of oxidative stress?
Quenby SM, Farquharson RG: Predicting recurring miscarriage: what is important?
Salmon AB, Richardson A, Perez VI: Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
Woods JR, Plessinger MA, Miller RK: Vitamins C and E: missing links in preventing preterm premature rupture of membranes?

Schema {🗺️}

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