We are analyzing https://link.springer.com/article/10.1186/1476-4598-6-27.

Title:
Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors | Molecular Cancer
Description:
The question of whether p73 is a tumor suppressor gene, is not yet answered with full confidence. The lack of spontaneous tumor formation in p73 null mice and infrequent p73 mutations seen in a variety of cancers analyzed would straightaway negate its role as a primary tumor suppressor gene. However, accumulating evidence suggest that p73 gene and its target genes are hypermethylated in the cancer of lymphoid origin. Here I discuss some facts and thoughts that support the idea that p73 could still be a tumor suppressor gene. The tumor suppressor network in which p73 appears to be a participant involves E2F1, JunB, INK4a/p16, ARF/p19, p57kip2 and BRCA1. Knock out of each gene in E2F-1-p73-JunB-p16INK4a network of tumor suppressor proteins result in lymphoma/leukemia formation. Further, I tried to explain why lymphomas are not seen in p73 null mice and why p73 gene is not prone to frequent mutation.
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Keywords {🔍}

tumor, pubmed, article, gene, google, scholar, cas, suppressor, expression, mice, cell, shown, cancer, cells, null, junb, lymphoma, tumors, promoter, leukemia, adenosine, figure, proliferation, target, pkip, apoptosis, methylation, myeloid, human, sigma, develop, function, functions, pathway, transcriptional, genes, dna, network, formation, suggest, cpg, hypermethylation, res, central, access, brca, oncogene, growth, inactivation, increased,

Topics {✒️}

transactivation-deficient deltata-p73 acts open access article t-cell tumour suppressor antigen-induced t-cell proliferation article download pdf ccaat/enhancer binding proteins expressing wild-type p53 expressing wild-type p73 acute lymphocytic leukemia cell-cycle regulatory pathway coiled-coil-mediated interaction human hepatoma li-7a chronic myeloid leukemia splenic t-cells isolated e2f1-/+e2f2-/- mice developed cisplatin-induced dna damage related subjects aberrantly expressd c-jun p73/p63 null mice elicit anti-proliferative effect authors’ original file acute nonlymphocytic leukemia acute promyelocytic leukemia[34] cell death differ acute lymphoblastic leukemia e2f-1-p73-junb-p16ink4a network acute lymphoplastic leukemia privacy choices/manage cookies e2f1-deficient mice ubiquitin-dependent degradation tumor suppressor pathway sumo-1 interaction motif myeloid hyperplasia/leukemia article boominathan p73 null mice tumor cell types derived cell lines[16] p73-deficient mice dna damage signals antioncogenic response triggered sumo-1-interacting proteins tumor suppressor gene tumor suppressor gene[46] p73 splicing products t-cell receptors suppresses tumor growth human cancer cells dna methyl transfereases dna damaging drugs aberrant dna methylation

Questions {❓}

How can we explain this tumor paradox?
If indeed p73 is a tumor suppressor gene, then why p73 null mice failed to develop lymphoma?
Stiewe T, Putzer BM: Role of p73 in malignancy: tumor suppressor or oncogene?
Why do p73 mutations are infrequent in tumors?

Schema {🗺️}

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            Intraductal Papillary Mucinous Neoplasm
            Cancer Research
            Oncology
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      headline:Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors
      description:The question of whether p73 is a tumor suppressor gene, is not yet answered with full confidence. The lack of spontaneous tumor formation in p73 null mice and infrequent p73 mutations seen in a variety of cancers analyzed would straightaway negate its role as a primary tumor suppressor gene. However, accumulating evidence suggest that p73 gene and its target genes are hypermethylated in the cancer of lymphoid origin. Here I discuss some facts and thoughts that support the idea that p73 could still be a tumor suppressor gene. The tumor suppressor network in which p73 appears to be a participant involves E2F1, JunB, INK4a/p16, ARF/p19, p57kip2 and BRCA1. Knock out of each gene in E2F-1-p73-JunB-p16INK4a network of tumor suppressor proteins result in lymphoma/leukemia formation. Further, I tried to explain why lymphomas are not seen in p73 null mice and why p73 gene is not prone to frequent mutation.
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         Intraductal Papillary Mucinous Neoplasm
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         Oncology
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