We are analyzing https://link.springer.com/article/10.1186/1476-4598-2-10.

Title:
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer | Molecular Cancer
Description:
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.
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Keywords {🔍}

cancer, pubmed, google, scholar, cox, pancreatic, cas, lox, article, cell, cells, expression, apoptosis, inhibitors, growth, cyclooxygenase, lipoxygenase, human, role, res, proliferation, acid, tumor, studies, treatment, prostaglandin, inhibitor, effects, endothelial, inhibition, activation, pathway, development, angiogenesis, arachidonic, mice, lung, inhibits, prostate, receptor, prevention, specific, activity, thromboxane, adrian, carcinogenesis, tissues, induced, biol, ding,

Topics {✒️}

interleukin-6/gp130/stat-3 signaling pathway steroidal anti-inflammatory drug beta-adrenergic receptor-mediated release nonsteroidal anti-inflammatory drug tumor necrosis factor-α apo2l/trail differentially modulates steroidal anti-inflammatory agent nonsteroidal anti-inflammatory drugs xian-zhong ding t-cell factor signaling article download pdf protein kinase c-alpha erk2/jnk1 signaling pathways egf-mediated signaling pathways tumor promoter-elicited events pi3 kinase/akt cascade phosphatidylinositol 3-kinase/akt pathway prostaglandin synthase-mediated metabolism anti-pancreatic cancer activity g-protein-coupled receptors short-lived molecule required including mutated k-ras cyclooxygenase-2-dependent endothelial migration cell-cycle gene expression cytochrome c-dependent pathway extracellular signal-regulated kinase1/2 platelet-free human monocytes ly293111 blocks growth open access license prevent ns398-induced cytochrome 15-s-hete inhibits proliferation anti-cox-2 agents extracted lipoxygenase inhibitor-induced apoptosis cox-1-deficient min mice ltb4 receptor antagonist 13-s-hode induces apoptosis bop-induced pancreatic cancer natural killer cells celecoxib significantly decreases stimulates dna synthesis increases e-cadherin production garlic-derived natural product cell cycle arrest specific receptor antagonists pro-apoptotic protein pancreatic cancer research cox-2-mediated vegf expression mediated dna damage cyclo-oxygenase-2 inhibitor ns398 receptor-mediated hydrolysis

Schema {🗺️}

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         headline:Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
         description:The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.
         datePublished:2003-01-07T00:00:00Z
         dateModified:2003-01-07T00:00:00Z
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            Cancer Research
            Oncology
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      headline:Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
      description:The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.
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      name:Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, U.S.A
      name:Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, U.S.A

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