We are analyzing https://link.springer.com/article/10.1186/1476-4598-11-7.

Title:
Wnt signaling pathways in urological cancers: past decades and still growing | Molecular Cancer
Description:
The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to tumor development, progression and metastasis in various cancers. In this review, the Wnt pathway will be covered from the perspective of urological cancers with emphasis placed on the recent published literature. Regulation of the Wnt signaling pathway by microRNAs (miRNA), small RNA sequences that modify gene expression profiles will also be discussed. An improved understanding of the basic genetics and biology of Wnt signaling pathway will provide insights into the development of novel chemopreventive and therapeutic strategies for urological cancers.
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Keywords {🔍}

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Topics {✒️}

f-box/wd40-repeat protein slimb amino-terminal cysteine-rich domain jun n-terminal kinase von hippel-lindau protein activating beta-catenin/tcf signalling von-hippel lindau disease ck1-α phosphorylates β-catenin active wnt/β-catenin signaling aberrant wnt/β-catenin signaling beta-catenin-independent wnt signaling wnt/beta-catenin signaling pathway open access article wnt/β-catenin pathway resulted epithelial-mesenchymal-transitional markers twist wnt/β-catenin signaling pathway wnt/beta-catenin pathway activity wnt/β-catenin pathway activation article download pdf von hippel-lindau ar/tmprss2-erg fusion parathyroid hormone-related protein noncanonical wnt/fz signaling t-cell factor activity stabilized β-catenin enters beta-catenin-tcf complex beta-catenin-tcf signaling β-catenin/tcf4 complex [71] secreted-frizzled related protein secreted frizzled-related protein-5 transcriptional coactivator β-catenin cysteine-rich frizzled domain signet-ring cell carcinoma multi-gene regulatory capacity wnt-dependent signaling pathways transforming growth factor-beta wnt/beta-catenin signaling life-long developmental deficits beta-catenin-independent pathways wnt/β-catenin signaling steroidal anti-inflammatory drugs beta-catenin activation synergizes hypoxia-inducible gene deregulation ubiquitinates β-catenin leading wnt/beta-catenin pathway g-protein-dependent manner tcf/lef transcription factors nuclear b-catenin accumulation wnt/β-catenin pathway [77–80] wnt/β-catenin pathway e3-ubiquitin ligase activity

Schema {🗺️}

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         headline:Wnt signaling pathways in urological cancers: past decades and still growing
         description:The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to tumor development, progression and metastasis in various cancers. In this review, the Wnt pathway will be covered from the perspective of urological cancers with emphasis placed on the recent published literature. Regulation of the Wnt signaling pathway by microRNAs (miRNA), small RNA sequences that modify gene expression profiles will also be discussed. An improved understanding of the basic genetics and biology of Wnt signaling pathway will provide insights into the development of novel chemopreventive and therapeutic strategies for urological cancers.
         datePublished:2012-02-10T00:00:00Z
         dateModified:2012-02-10T00:00:00Z
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            Baldder Cancer
            MicroRNAs
            Cancer Research
            Oncology
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      headline:Wnt signaling pathways in urological cancers: past decades and still growing
      description:The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to tumor development, progression and metastasis in various cancers. In this review, the Wnt pathway will be covered from the perspective of urological cancers with emphasis placed on the recent published literature. Regulation of the Wnt signaling pathway by microRNAs (miRNA), small RNA sequences that modify gene expression profiles will also be discussed. An improved understanding of the basic genetics and biology of Wnt signaling pathway will provide insights into the development of novel chemopreventive and therapeutic strategies for urological cancers.
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      dateModified:2012-02-10T00:00:00Z
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         Wnt pathway
         Kidney
         Prostate
         Baldder Cancer
         MicroRNAs
         Cancer Research
         Oncology
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      name:Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, USA
      name:Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, USA
      name:Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, San Francisco, USA
      name:Professor and Director, Urology Research Center (112 F), Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, USA

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