We are analyzing https://link.springer.com/article/10.1186/1471-2407-8-108.

Title:
Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells | BMC Cancer
Description:
Background Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. The roles of Nanog, NS and Msi1 in development and progression of cervical carcinoma have, until now, not been well documented. Methods In this study, expression of Nanog, NS and Msi1 was detected by immunohistochemistry analysis in 235 patients with various degrees of cervical epithelial lesions, including 49 with normal cervical epithelia, 31 with mild dysplasia (CIN I), 77 with moderate-severe dysplasia (CIN II-III) and 78 with squamous cervical carcinomas (SCCs). Associations with various clinical pathological prognostic variables were analyzed in 50 early-stage SCC patients. Results Nanog, NS and Msi1 expression levels were significantly higher in SCC patients compared with CIN patients, and were higher in CIN patients compared with those with normal cervical epithelia. Nanog expression levels showed significantly differences according to different tumor sizes (P < 0.05), whereas there were no differences in NS and Msi1 expression levels according to different clinical pathological parameters. Conclusion Our findings indicate that Nanog, NS and Msi1 may be involved in carcinogenesis of the cervix and progression of cervical carcinoma.
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Keywords {🔍}

cells, cervical, nanog, expression, msi, cell, article, pubmed, normal, cancer, google, scholar, cas, stem, patients, levels, carcinoma, human, epithelial, scc, nucleostemin, embryonic, positive, proteins, musashi, cin, expressed, proliferation, neural, analysis, development, study, protein, cytoplasm, authors, tumor, differentiation, gene, role, tissues, clinical, central, important, marker, access, pluripotency, epithelia, results, rnabinding, samples,

Topics {✒️}

stem-cell-abundant proteins nanog n-terminal rna-binding domain stem-cell-abundant proteins normal cervical epithelium neural stem/progenitor cells pre-publication history open access article lymph-vascular space invasion squamous cervical carcinomas nk-type homeobox gene cervical carcinoma treatment regulate stem-cell differentiation rna-binding protein neural stem cells malignant renal tissues article download pdf cervical carcinoma tissues cancer cell lines cervical epithelial cells cervical epithelial lesions neural progenitor cells[6] mouse neural protein normal cervical epithelia bmc cancer 8 cancer-cell proliferation [4] normal goat serum undifferentiated embryonic stem cervical carcinoma cervical carcinoma[19] mammalian numb embryonic stem cells privacy choices/manage cookies stem/progenitor cells pluripotent cell lines clinical pathological parameters authors’ original file avidin-biotin complex mol cell biol human glioma cells regulates nanog expression mouse es cell distinct brown color epithelial cell early-stage scc cell proliferation rate full access distinct brown coloration normal rabbit serum excess normal serum human placenta tissue

Schema {🗺️}

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         headline:Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells
         description:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. The roles of Nanog, NS and Msi1 in development and progression of cervical carcinoma have, until now, not been well documented. In this study, expression of Nanog, NS and Msi1 was detected by immunohistochemistry analysis in 235 patients with various degrees of cervical epithelial lesions, including 49 with normal cervical epithelia, 31 with mild dysplasia (CIN I), 77 with moderate-severe dysplasia (CIN II-III) and 78 with squamous cervical carcinomas (SCCs). Associations with various clinical pathological prognostic variables were analyzed in 50 early-stage SCC patients. Nanog, NS and Msi1 expression levels were significantly higher in SCC patients compared with CIN patients, and were higher in CIN patients compared with those with normal cervical epithelia. Nanog expression levels showed significantly differences according to different tumor sizes (P < 0.05), whereas there were no differences in NS and Msi1 expression levels according to different clinical pathological parameters. Our findings indicate that Nanog, NS and Msi1 may be involved in carcinogenesis of the cervix and progression of cervical carcinoma.
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            Renal Cell Carcinoma Cell Line
            Cervical Epithelial Cell
            Normal Cervical Epithelium
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            Oncology
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            Health Promotion and Disease Prevention
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      headline:Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells
      description:Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and asymmetric division of ES cells and several nervous system tumor cells. The roles of Nanog, NS and Msi1 in development and progression of cervical carcinoma have, until now, not been well documented. In this study, expression of Nanog, NS and Msi1 was detected by immunohistochemistry analysis in 235 patients with various degrees of cervical epithelial lesions, including 49 with normal cervical epithelia, 31 with mild dysplasia (CIN I), 77 with moderate-severe dysplasia (CIN II-III) and 78 with squamous cervical carcinomas (SCCs). Associations with various clinical pathological prognostic variables were analyzed in 50 early-stage SCC patients. Nanog, NS and Msi1 expression levels were significantly higher in SCC patients compared with CIN patients, and were higher in CIN patients compared with those with normal cervical epithelia. Nanog expression levels showed significantly differences according to different tumor sizes (P < 0.05), whereas there were no differences in NS and Msi1 expression levels according to different clinical pathological parameters. Our findings indicate that Nanog, NS and Msi1 may be involved in carcinogenesis of the cervix and progression of cervical carcinoma.
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         Cervical Carcinoma
         Renal Cell Carcinoma Cell Line
         Cervical Epithelial Cell
         Normal Cervical Epithelium
         Squamous Cervical Carcinoma
         Cancer Research
         Oncology
         Surgical Oncology
         Health Promotion and Disease Prevention
         Biomedicine
         general
         Medicine/Public Health
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            name:Zhejiang University
            address:
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      name:Jiajie Shen
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