We are analyzing https://link.springer.com/article/10.1186/1471-2407-5-121.

Title:
Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts | BMC Cancer
Description:
Background The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts. Methods We first immunostained a wide variety of human cancers for the presence of degranulated mast cells. In a subsequent series of controlled in vitro experiments, we then co-cultured UACC-812 human breast cancer cells with normal fibroblasts in the presence or absence of different combinations and doses of mast cell tryptase, mast cell heparin, a lysate of the human mast cell line HMC-1, and fibroblast growth factor-7 (FGF-7), a powerful, heparin-binding growth factor for breast epithelial cells. Results Degranulating mast cells were localized predominantly in the fibrous tissue of every case of breast cancer, head and neck cancer, lung cancer, ovarian cancer, non-Hodgkin
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Keywords {🔍}

cells, mast, heparin, cell, fibroblasts, cancer, tumor, growth, human, fgf, article, pubmed, breast, google, scholar, cas, tryptase, tumors, colonies, presence, figure, normal, tissue, clonogenic, effect, produced, control, factor, cultured, effects, cocultured, line, results, fibrous, size, numbers, assay, mice, mechanism, absence, hmc, studies, granules, coculture, number, significantly, adjacent, performed, antibody, central,

Topics {✒️}

open access article peri-tumoral blood clotting elevated sdf-1/cxcl12 secretion peri-tumoral blood vessels 2-dimethylhydrazine-induced intestinal tumors pre-publication history 3 ug/ml anti-fgf7 peri-tumoral fibrous tissue mast cell-deficient kit mann-whitney u-test article download pdf opti-4cn detection kit improved anti-tumor therapies de-paraffinized tissue sections anti-tumor effect mediated degranulating mast cells low-molecular-weight heparin heparin-binding growth factor tailed unpaired t-test heparin-binding growth factors indirect mechanism involving related subjects fibroblast growth factor-7 irrelevant cell line mast cells promote polyclonal antibody recognized hmc-1 cell line increased blood clotting authors’ original file privacy choices/manage cookies mast cell tryptase mast-cell tryptase mast cell compounds article samoszuk uci medical center mast cell degranulation monoclonal antibody directed multiple complex interactions mast cell infiltration mast cell granules ndst-2 knockout mice irrelevant monoclonal antibody lung-derived tryptase mechanism involving fibroblasts heparan sulfate proteoglycans human breast cancer /kit w-vmice kakkar ak human breast cells abnormal mast cells

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         headline:Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts
         description:The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts. We first immunostained a wide variety of human cancers for the presence of degranulated mast cells. In a subsequent series of controlled in vitro experiments, we then co-cultured UACC-812 human breast cancer cells with normal fibroblasts in the presence or absence of different combinations and doses of mast cell tryptase, mast cell heparin, a lysate of the human mast cell line HMC-1, and fibroblast growth factor-7 (FGF-7), a powerful, heparin-binding growth factor for breast epithelial cells. Degranulating mast cells were localized predominantly in the fibrous tissue of every case of breast cancer, head and neck cancer, lung cancer, ovarian cancer, non-Hodgkin's lymphoma, and Hodgkin's disease that we examined. Mast cell tryptase and HMC-1 lysate had no significant effect on the clonogenic growth of cancer cells co-cultured with fibroblasts. By contrast, mast cell heparin at multiple doses significantly reduced the size and number of colonies of tumor cells co-cultured with fibroblasts, especially in the presence of FGF-7. Neither heparin nor FGF-7, individually or in combination, produced any significant effect on the clonogenic growth of breast cancer cells cultured without fibroblasts. Degranulating mast cells are restricted to peri-tumoral fibrous tissue, and mast cell heparin is a powerful inhibitor of clonogenic growth of tumor cells co-cultured with fibroblasts. These results may help to explain the well-known ability of heparin to inhibit the growth of primary and metastatic tumors.
         datePublished:2005-09-21T00:00:00Z
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      headline:Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts
      description:The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts. We first immunostained a wide variety of human cancers for the presence of degranulated mast cells. In a subsequent series of controlled in vitro experiments, we then co-cultured UACC-812 human breast cancer cells with normal fibroblasts in the presence or absence of different combinations and doses of mast cell tryptase, mast cell heparin, a lysate of the human mast cell line HMC-1, and fibroblast growth factor-7 (FGF-7), a powerful, heparin-binding growth factor for breast epithelial cells. Degranulating mast cells were localized predominantly in the fibrous tissue of every case of breast cancer, head and neck cancer, lung cancer, ovarian cancer, non-Hodgkin's lymphoma, and Hodgkin's disease that we examined. Mast cell tryptase and HMC-1 lysate had no significant effect on the clonogenic growth of cancer cells co-cultured with fibroblasts. By contrast, mast cell heparin at multiple doses significantly reduced the size and number of colonies of tumor cells co-cultured with fibroblasts, especially in the presence of FGF-7. Neither heparin nor FGF-7, individually or in combination, produced any significant effect on the clonogenic growth of breast cancer cells cultured without fibroblasts. Degranulating mast cells are restricted to peri-tumoral fibrous tissue, and mast cell heparin is a powerful inhibitor of clonogenic growth of tumor cells co-cultured with fibroblasts. These results may help to explain the well-known ability of heparin to inhibit the growth of primary and metastatic tumors.
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      dateModified:2005-09-21T00:00:00Z
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         Mast Cell
         Tryptase
         Degranulating Mast Cell
         Normal Human Fibroblast
         Mast Cell Tryptase
         Cancer Research
         Oncology
         Surgical Oncology
         Health Promotion and Disease Prevention
         Biomedicine
         general
         Medicine/Public Health
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