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We are analyzing https://link.springer.com/article/10.1186/1471-2407-10-483.

Title:
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions | BMC Cancer
Description:
Background Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions. Methods We have used a cohort comprising normal breast, benign mammary lesions, carcinomas in situ and invasive carcinomas and assessed the expression of the VDR, CYP27B1 and CYP24A1 by immunohistochemistry. Results The results that we have obtained show that all proteins are expressed in the various breast tissues, although at different amounts. The VDR was frequently expressed in benign lesions (93.5%) and its levels of expression were diminished in invasive tumours (56.2%). Additionally, the VDR was strongly associated with the oestrogen receptor positivity in breast carcinomas. CYP27B1 expression is slightly lower in invasive carcinomas (44.6%) than in benign lesions (55.8%). In contrast, CYP24A1 expression was augmented in carcinomas (56.0% in in situ and 53.7% in invasive carcinomas) when compared with that in benign lesions (19.0%). Conclusions From this study, we conclude that there is a deregulation of the Vitamin D signalling and metabolic pathways in breast cancer, favouring tumour progression. Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Schema {🗺️}

WebPage:
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         headline:Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions
         description:Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions. We have used a cohort comprising normal breast, benign mammary lesions, carcinomas in situ and invasive carcinomas and assessed the expression of the VDR, CYP27B1 and CYP24A1 by immunohistochemistry. The results that we have obtained show that all proteins are expressed in the various breast tissues, although at different amounts. The VDR was frequently expressed in benign lesions (93.5%) and its levels of expression were diminished in invasive tumours (56.2%). Additionally, the VDR was strongly associated with the oestrogen receptor positivity in breast carcinomas. CYP27B1 expression is slightly lower in invasive carcinomas (44.6%) than in benign lesions (55.8%). In contrast, CYP24A1 expression was augmented in carcinomas (56.0% in in situ and 53.7% in invasive carcinomas) when compared with that in benign lesions (19.0%). From this study, we conclude that there is a deregulation of the Vitamin D signalling and metabolic pathways in breast cancer, favouring tumour progression. Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.
         datePublished:2010-09-11T00:00:00Z
         dateModified:2010-09-11T00:00:00Z
         pageStart:1
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         license:https://creativecommons.org/licenses/by/2.0
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         keywords:
            Mammary Gland
            Benign Lesion
            Invasive Carcinoma
            Breast Lesion
            Normal Breast Tissue
            Cancer Research
            Oncology
            Surgical Oncology
            Health Promotion and Disease Prevention
            Biomedicine
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      headline:Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions
      description:Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions. We have used a cohort comprising normal breast, benign mammary lesions, carcinomas in situ and invasive carcinomas and assessed the expression of the VDR, CYP27B1 and CYP24A1 by immunohistochemistry. The results that we have obtained show that all proteins are expressed in the various breast tissues, although at different amounts. The VDR was frequently expressed in benign lesions (93.5%) and its levels of expression were diminished in invasive tumours (56.2%). Additionally, the VDR was strongly associated with the oestrogen receptor positivity in breast carcinomas. CYP27B1 expression is slightly lower in invasive carcinomas (44.6%) than in benign lesions (55.8%). In contrast, CYP24A1 expression was augmented in carcinomas (56.0% in in situ and 53.7% in invasive carcinomas) when compared with that in benign lesions (19.0%). From this study, we conclude that there is a deregulation of the Vitamin D signalling and metabolic pathways in breast cancer, favouring tumour progression. Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.
      datePublished:2010-09-11T00:00:00Z
      dateModified:2010-09-11T00:00:00Z
      pageStart:1
      pageEnd:10
      license:https://creativecommons.org/licenses/by/2.0
      sameAs:https://doi.org/10.1186/1471-2407-10-483
      keywords:
         Mammary Gland
         Benign Lesion
         Invasive Carcinoma
         Breast Lesion
         Normal Breast Tissue
         Cancer Research
         Oncology
         Surgical Oncology
         Health Promotion and Disease Prevention
         Biomedicine
         general
         Medicine/Public Health
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-2407-10-483/MediaObjects/12885_2010_Article_2282_Fig1_HTML.jpg
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            name:Nair Lopes
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                  name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
                  address:
                     name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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                     name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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                     name:Department of Pathology, General Hospital of UNIMED (Rua Gaspar de Lemos, 2), Araçatuba, Brazil
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                     name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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                     name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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                  address:
                     name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
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      name:Bárbara Sousa
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            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
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      name:Diana Martins
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            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:Madalena Gomes
      affiliation:
            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:Daniella Vieira
      affiliation:
            name:Federal University of Santa Catarina (Campus Reitor João David Ferreira Lima)
            address:
               name:Department of Pathology, Federal University of Santa Catarina (Campus Reitor João David Ferreira Lima), Florianópolis, Brazil
               type:PostalAddress
            type:Organization
      name:Luiz A Veronese
      affiliation:
            name:General Hospital of UNIMED (Rua Gaspar de Lemos, 2)
            address:
               name:Department of Pathology, General Hospital of UNIMED (Rua Gaspar de Lemos, 2), Araçatuba, Brazil
               type:PostalAddress
            type:Organization
      name:Fernanda Milanezi
      affiliation:
            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:Joana Paredes
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            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:José L Costa
      affiliation:
            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:Fernando Schmitt
      affiliation:
            name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n)
            address:
               name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
               type:PostalAddress
            type:Organization
            name:Medical Faculty of the University of Porto (Alameda Prof. Hernâni Monteiro)
            address:
               name:Medical Faculty of the University of Porto (Alameda Prof. Hernâni Monteiro), Porto, Portugal
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:Department of Pathology, Federal University of Santa Catarina (Campus Reitor João David Ferreira Lima), Florianópolis, Brazil
      name:Department of Pathology, General Hospital of UNIMED (Rua Gaspar de Lemos, 2), Araçatuba, Brazil
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto (Rua Dr Roberto Frias, s/n), Porto, Portugal
      name:Medical Faculty of the University of Porto (Alameda Prof. Hernâni Monteiro), Porto, Portugal

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