We are analyzing https://link.springer.com/article/10.1186/1471-2407-10-270.

Title:
Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma | BMC Cancer
Description:
Introduction The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the survival of patients with NPC. Methods Using real-time PCR, we detected the mRNA expression of MMP9 in normal nasopharyngeal tissues and nasopharyngeal carcinoma (NPC) tissues. Using immunohistochemistry analysis, we analyzed MMP9 protein expression in clinicopathologically characterized 164 NPC cases (116 male and 48 female) with age ranging from 17 to 80 years (median = 48.4 years) and 32 normal nasopharyngeal tissues. Cases with greater than or equal to 6 and less than 6 of the score value of cytoplasmic MMP9 immunostaining were regarded as high expression and low expression, respectively. The relationship between the expression levels of MMP9 and clinical features was analyzed. Results The expression level of MMP9 mRNA was markedly greater in NPC tissues than that in the nasopharyngeal tissues. Immunohistochemical analysis revealed that the protein expression of MMP9 detected in NPC tissues was higher than that in the nasopharyngeal tissues (P = 0.004). In addition, high levels of MMP9 protein were positively correlated with the status of lymph node metastasis (N classification) (P = 0.002) and clinical stage (P < 0.001) of NPC patients. Patients with higher MMP9 expression had a significantly shorter overall survival time than did patients with low MMP9 expression. Multivariate analysis suggested that the level of MMP9 expression was an independent prognostic indicator (P = 0.008) for the survival of patients with NPC. Conclusion High level of MMP9 expression is a potential unfavorable prognostic factor for patients with NPC.
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Keywords {🔍}

mmp, npc, expression, cancer, patients, article, nasopharyngeal, pubmed, protein, tissues, survival, google, scholar, matrix, carcinoma, metalloproteinase, metastasis, cas, analysis, levels, prognosis, tumor, samples, mrna, clinical, prognostic, table, correlated, liu, level, cells, data, classification, significantly, noncancerous, china, staining, size, central, research, expressed, overexpressed, authors, bmc, increased, access, full, study, results, higher,

Topics {✒️}

nasal nk/t-cell lymphoma epstein-barr virus infection weiren luo open access article search valuable factors p38{gamma} mapk cooperates performed real-time pcr kaplan-meier survival analysis heat-induced antigen retrieval streptavidin-conjugated horseradish peroxidase pre-publication history article download pdf shortened cancer-related survival 10-year disease-related survival real-time pcr tumor-related molecular expression kaplan-meier analysis c33a cell line undifferentiated nasopharyngeal carcinoma kaplan-meier method overexpressed mmp9 protein privacy choices/manage cookies full access related subjects recent microarray analysis limited sample size view mmp9 protein expression lateral nasopharyngeal recess authors’ original file cell surface association normal nasopharyngeal tissues cancerous nasopharyngeal samples cancerous nasopharyngeal tissues immunohistochemical analysis revealed mmp9 mrna transcripts head neck higher protein expression bin wu epithelial ovarian cancer weiyi fang protein expression levels positive mmp9 expression cancerous nasopharyngeal specimens unfavorable prognostic factor cytoplasmic mmp9 immunostaining common malignant diseases brb-array tools peroxidase blocking reagent 3-diaminobenzidine chromogen solution

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         headline:Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma
         description:The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the survival of patients with NPC. Using real-time PCR, we detected the mRNA expression of MMP9 in normal nasopharyngeal tissues and nasopharyngeal carcinoma (NPC) tissues. Using immunohistochemistry analysis, we analyzed MMP9 protein expression in clinicopathologically characterized 164 NPC cases (116 male and 48 female) with age ranging from 17 to 80 years (median = 48.4 years) and 32 normal nasopharyngeal tissues. Cases with greater than or equal to 6 and less than 6 of the score value of cytoplasmic MMP9 immunostaining were regarded as high expression and low expression, respectively. The relationship between the expression levels of MMP9 and clinical features was analyzed. The expression level of MMP9 mRNA was markedly greater in NPC tissues than that in the nasopharyngeal tissues. Immunohistochemical analysis revealed that the protein expression of MMP9 detected in NPC tissues was higher than that in the nasopharyngeal tissues (P = 0.004). In addition, high levels of MMP9 protein were positively correlated with the status of lymph node metastasis (N classification) (P = 0.002) and clinical stage (P < 0.001) of NPC patients. Patients with higher MMP9 expression had a significantly shorter overall survival time than did patients with low MMP9 expression. Multivariate analysis suggested that the level of MMP9 expression was an independent prognostic indicator (P = 0.008) for the survival of patients with NPC. High level of MMP9 expression is a potential unfavorable prognostic factor for patients with NPC.
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      headline:Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma
      description:The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the survival of patients with NPC. Using real-time PCR, we detected the mRNA expression of MMP9 in normal nasopharyngeal tissues and nasopharyngeal carcinoma (NPC) tissues. Using immunohistochemistry analysis, we analyzed MMP9 protein expression in clinicopathologically characterized 164 NPC cases (116 male and 48 female) with age ranging from 17 to 80 years (median = 48.4 years) and 32 normal nasopharyngeal tissues. Cases with greater than or equal to 6 and less than 6 of the score value of cytoplasmic MMP9 immunostaining were regarded as high expression and low expression, respectively. The relationship between the expression levels of MMP9 and clinical features was analyzed. The expression level of MMP9 mRNA was markedly greater in NPC tissues than that in the nasopharyngeal tissues. Immunohistochemical analysis revealed that the protein expression of MMP9 detected in NPC tissues was higher than that in the nasopharyngeal tissues (P = 0.004). In addition, high levels of MMP9 protein were positively correlated with the status of lymph node metastasis (N classification) (P = 0.002) and clinical stage (P < 0.001) of NPC patients. Patients with higher MMP9 expression had a significantly shorter overall survival time than did patients with low MMP9 expression. Multivariate analysis suggested that the level of MMP9 expression was an independent prognostic indicator (P = 0.008) for the survival of patients with NPC. High level of MMP9 expression is a potential unfavorable prognostic factor for patients with NPC.
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      name:Department of Respiratory Medicine and Cancer Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China
      name:Department of Respiratory Medicine and Cancer Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China
      name:Cancer Research Institute, Key Lab for Transcriptomics and Proteomics of Human Fatal Diseases Supported by Ministry of Education and Guangdong Province, Southern Medical University, Guangzhou, P.R. China
      name:Institute of Clinical Medicine, First Affiliated Hospital of University of South China, Hengyang, P.R. China
      name:Cancer Research Institute, Key Lab for Transcriptomics and Proteomics of Human Fatal Diseases Supported by Ministry of Education and Guangdong Province, Southern Medical University, Guangzhou, P.R. China
      name:Department of Respiratory Medicine and Cancer Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China
      name:Cancer Research Institute, Key Lab for Transcriptomics and Proteomics of Human Fatal Diseases Supported by Ministry of Education and Guangdong Province, Southern Medical University, Guangzhou, P.R. China

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