We are analyzing https://link.springer.com/article/10.1186/1471-2172-9-1.

Title:
HLA class I supertypes: a revised and updated classification | BMC Immunology
Description:
Background Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of the presented peptide. These receptors are extremely polymorphic, and much of the polymorphism influences the peptide-binding repertoire. However, despite this polymorphism, class I molecules can be clustered into sets of molecules that bind largely overlapping peptide repertoires. Almost a decade ago we introduced this concept of clustering human leukocyte antigen (HLA) alleles and defined nine different groups, denominated as supertypes, on the basis of their main anchor specificity. The utility of this original supertype classification, as well several other subsequent arrangements derived by others, has been demonstrated in a large number of epitope identification studies. Results Following our original approach, in the present report we provide an updated classification of HLA-A and -B class I alleles into supertypes. The present analysis incorporates the large amount of class I MHC binding data and sequence information that has become available in the last decade. As a result, over 80% of the 945 different HLA-A and -B alleles examined to date can be assigned to one of the original nine supertypes. A few alleles are expected to be associated with repertoires that overlap multiple supertypes. Interestingly, the current analysis did not identify any additional supertype specificities. Conclusion As a result of this updated analysis, HLA supertype associations have been defined for over 750 different HLA-A and -B alleles. This information is expected to facilitate epitope identification and vaccine design studies, as well as investigations into disease association and correlates of immunity. In addition, the approach utilized has been made more transparent, allowing others to utilize the classification approach going forward.
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Keywords {🔍}

pubmed, google, scholar, cas, alleles, supertype, binding, peptide, hla, supertypes, class, mhc, immunol, hlaa, specificity, pocket, sidney, molecules, sette, residues, pockets, table, peptides, human, classification, epitopes, southwood, central, analysis, epitope, sequence, antigen, cell, virus, data, vaccine, hlab, motif, allele, original, identification, full, database, anchor, specificities, assignments, identified, present, defined, assigned,

Topics {✒️}

nih-niaid contracts n01-ai-40023 major histocompatibility complex virus-specific t-cell responses h-2kd peptide-binding motif human leukocyte antigen induce cancer-reactive cytotoxic measles-mumps-rubella viral vaccine a24-supertype epitope cross-reacting open access article immunodominant hla-a2-restricted epitope including measles-mumps-rubella [33] human immunodeficiency virus a01–a24 cross-reactivity pattern b7-restricted ctl response virus-specific ctl responses significantly impact cross-reactivity hla-a3-restricted cytotoxic peptide-pulsed dendritic cells article download pdf predictable mhc-binding motif overlapping peptide-binding repertoires hla-a2-restricted protection seminal mhc-related databases full size image cell receptor cross-recognition a2-supertype share specificity human papilloma virus studying b7-supertype epitopes hla-b15 peptide ligands hla supertype-specific epitopes mhc-peptide binding repertoires epstein-barr virus analogue-based cancer vaccines major hla class full size table peptide c-terminal residue mhc-peptide binding specificity virus-specific cytotoxic specific mhc molecule a2 serological antigen epitope-based vaccine targets h-2dd complexed human gammaherpesviruses kaposi' mhc molecule formed hla-a2 supertype molecules del guercio mf privacy choices/manage cookies serological antigen similarities main anchor contacts peptide-binding groove

Schema {🗺️}

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         headline:HLA class I supertypes: a revised and updated classification
         description:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of the presented peptide. These receptors are extremely polymorphic, and much of the polymorphism influences the peptide-binding repertoire. However, despite this polymorphism, class I molecules can be clustered into sets of molecules that bind largely overlapping peptide repertoires. Almost a decade ago we introduced this concept of clustering human leukocyte antigen (HLA) alleles and defined nine different groups, denominated as supertypes, on the basis of their main anchor specificity. The utility of this original supertype classification, as well several other subsequent arrangements derived by others, has been demonstrated in a large number of epitope identification studies. Following our original approach, in the present report we provide an updated classification of HLA-A and -B class I alleles into supertypes. The present analysis incorporates the large amount of class I MHC binding data and sequence information that has become available in the last decade. As a result, over 80% of the 945 different HLA-A and -B alleles examined to date can be assigned to one of the original nine supertypes. A few alleles are expected to be associated with repertoires that overlap multiple supertypes. Interestingly, the current analysis did not identify any additional supertype specificities. As a result of this updated analysis, HLA supertype associations have been defined for over 750 different HLA-A and -B alleles. This information is expected to facilitate epitope identification and vaccine design studies, as well as investigations into disease association and correlates of immunity. In addition, the approach utilized has been made more transparent, allowing others to utilize the classification approach going forward.
         datePublished:2008-01-22T00:00:00Z
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            Allergology
            Vaccine
            Cytokines and Growth Factors
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      headline:HLA class I supertypes: a revised and updated classification
      description:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of the presented peptide. These receptors are extremely polymorphic, and much of the polymorphism influences the peptide-binding repertoire. However, despite this polymorphism, class I molecules can be clustered into sets of molecules that bind largely overlapping peptide repertoires. Almost a decade ago we introduced this concept of clustering human leukocyte antigen (HLA) alleles and defined nine different groups, denominated as supertypes, on the basis of their main anchor specificity. The utility of this original supertype classification, as well several other subsequent arrangements derived by others, has been demonstrated in a large number of epitope identification studies. Following our original approach, in the present report we provide an updated classification of HLA-A and -B class I alleles into supertypes. The present analysis incorporates the large amount of class I MHC binding data and sequence information that has become available in the last decade. As a result, over 80% of the 945 different HLA-A and -B alleles examined to date can be assigned to one of the original nine supertypes. A few alleles are expected to be associated with repertoires that overlap multiple supertypes. Interestingly, the current analysis did not identify any additional supertype specificities. As a result of this updated analysis, HLA supertype associations have been defined for over 750 different HLA-A and -B alleles. This information is expected to facilitate epitope identification and vaccine design studies, as well as investigations into disease association and correlates of immunity. In addition, the approach utilized has been made more transparent, allowing others to utilize the classification approach going forward.
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         Major Histocompatibility Complex
         Human Leukocyte Antigen
         Peptide Binding
         Human Leukocyte Antigen Class
         Major Histocompatibility Complex Molecule
         Immunology
         Allergology
         Vaccine
         Cytokines and Growth Factors
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            address:
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               type:PostalAddress
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      name:Nicole Frahm
      affiliation:
            name:Massachusetts General Hospital, Harvard Medical School
            address:
               name:Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
               type:PostalAddress
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      name:Christian Brander
      affiliation:
            name:Massachusetts General Hospital, Harvard Medical School
            address:
               name:Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
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