We are analyzing https://link.springer.com/article/10.1186/1471-2164-6-118.

Title:
Rapid single nucleotide polymorphism mapping in C. elegans | BMC Genomics
Description:
Background In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes. Results Here, we describe a set of 48 primer pairs that flank SNPs evenly spaced across the C. elegans genome and that work under identical PCR conditions. Each SNP in this set alters a Dra I site, enabling rapid and parallel scoring. We describe a procedure using these reagents to quickly and reliably map mutations. We show that these techniques correctly map a known gene, dpy-5. We then use these techniques to map mutations in an uncharacterized strain, and show that its behavioral phenotype can be simultaneously mapped to three loci. Conclusion Together, the reagents and methods described represent a significant advance in the accurate, rapid and inexpensive mapping of genes in C. elegans.
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Keywords {🔍}

mapping, snp, chromosome, pcr, animals, snps, plate, figure, primer, dpy, hawaiian, single, bristol, primers, interval, plates, elegans, mutant, genetic, dra, dna, progeny, data, polymorphism, phenotype, unce, mix, article, set, strain, methods, linkage, map, mutations, detection, gel, buffer, mutation, unc, nucleotide, pairs, technique, original, recombinant, suppressor, authors, markers, gene, homozygous, lysed,

Topics {✒️}

single-nucleotide polymorphism map single nucleotide polymorphism /projects/celegans/cgi-bin/getsnp /projects/celegans/cgi-bin/setsnp single nucleotide polymorphisms open access article bmc genomics 6 eg1000/cb4856 heterozygote hermaphrodites polymorphism detection eg1000/cb4856 f1 hermaphrodites conventional marker mutations article download pdf high-throughput gene mapping /projects/celegans/index single restriction enzyme authors’ original file privacy choices/manage cookies triply-marked mapping strain full size image single f2 animal polymorphism identified single recombinant animal require specialized equipment rapid gene mapping snp detection technique silent genetic markers closely related strain indel detection technique interval mapping differs additional mapping experiments snp detection methods simplified snp detection identical digestion cocktail related subjects informative digestion products interpolated genetic positions genetic intervals depicted interval mapping experiments complex techniques published european economic area sequence ttt^aaa south san francisco wells spaced half colored box represents sorval rt6000d centrifuge 4x lysis buffer salt lake city emj helped coordinate techniques correctly map snp mapping protocols

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Schema {🗺️}

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         headline:Rapid single nucleotide polymorphism mapping in C. elegans
         description:In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes. Here, we describe a set of 48 primer pairs that flank SNPs evenly spaced across the C. elegans genome and that work under identical PCR conditions. Each SNP in this set alters a Dra I site, enabling rapid and parallel scoring. We describe a procedure using these reagents to quickly and reliably map mutations. We show that these techniques correctly map a known gene, dpy-5. We then use these techniques to map mutations in an uncharacterized strain, and show that its behavioral phenotype can be simultaneously mapped to three loci. Together, the reagents and methods described represent a significant advance in the accurate, rapid and inexpensive mapping of genes in C. elegans.
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            Interval Mapping
            Single Nucleotide Polymorphism Marker
            Single Nucleotide Polymorphism Detection
            Single Nucleotide Polymorphism Mapping
            Life Sciences
            general
            Microarrays
            Proteomics
            Animal Genetics and Genomics
            Microbial Genetics and Genomics
            Plant Genetics and Genomics
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      headline:Rapid single nucleotide polymorphism mapping in C. elegans
      description:In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes. Here, we describe a set of 48 primer pairs that flank SNPs evenly spaced across the C. elegans genome and that work under identical PCR conditions. Each SNP in this set alters a Dra I site, enabling rapid and parallel scoring. We describe a procedure using these reagents to quickly and reliably map mutations. We show that these techniques correctly map a known gene, dpy-5. We then use these techniques to map mutations in an uncharacterized strain, and show that its behavioral phenotype can be simultaneously mapped to three loci. Together, the reagents and methods described represent a significant advance in the accurate, rapid and inexpensive mapping of genes in C. elegans.
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         Single Nucleotide Polymorphism
         Interval Mapping
         Single Nucleotide Polymorphism Marker
         Single Nucleotide Polymorphism Detection
         Single Nucleotide Polymorphism Mapping
         Life Sciences
         general
         Microarrays
         Proteomics
         Animal Genetics and Genomics
         Microbial Genetics and Genomics
         Plant Genetics and Genomics
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