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  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
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  6. Keywords
  7. Topics
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We are analyzing https://link.springer.com/article/10.1186/1471-2164-14-104.

Title:
A highly expressed miR-101 isomiR is a functional silencing small RNA | BMC Genomics
Description:
Background MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterogeneity at length and sequence level for the majority of mature miRNAs (IsomiRs). Most isomiRs can be explained by variability in either Dicer1 or Drosha cleavage during miRNA biogenesis at 5’ or 3’ of the miRNA (trimming variants). Although isomiRs have been described in different tissues and organisms, their functional validation as modulators of gene expression remains elusive. Here we have characterized the expression and function of a highly abundant miR-101 5’-trimming variant (5’-isomiR-101). Results The analysis of small RNA sequencing data in several human tissues and cell lines indicates that 5’-isomiR-101 is ubiquitously detected and a highly abundant, especially in the brain. 5’-isomiR-101 was found in Ago-2 immunocomplexes and complementary approaches showed that 5’-isomiR-101 interacted with different members of the silencing (RISC) complex. In addition, 5’-isomiR-101 decreased the expression of five validated miR-101 targets, suggesting that it is a functional variant. Both the binding to RISC members and the degree of silencing were less efficient for 5’-isomiR-101 compared with miR-101. For some targets, both miR-101 and 5’-isomiR-101 significantly decreased protein expression with no changes in the respective mRNA levels. Although a high number of overlapping predicted targets suggest similar targeted biological pathways, a correlation analysis of the expression profiles of miR-101 variants and predicted mRNA targets in human brains at different ages, suggest specific functions for miR-101- and 5’-isomiR-101. Conclusions These results suggest that isomiRs are functional variants and further indicate that for a given miRNA, the different isomiRs may contribute to the overall effect as quantitative and qualitative fine-tuners of gene expression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
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What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💾}

We're unsure if the website is profiting.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

isomir, pubmed, expression, article, google, scholar, mirna, human, cas, variants, ago, cells, central, figure, rna, gene, cell, genes, isomirs, microrna, shsyy, data, targets, control, sequence, transfected, brain, seed, expressed, sequencing, mrna, levels, sequences, file, analysis, risc, silencing, ezh, mirnas, target, samples, abundant, small, number, trimming, cancer, sample, shown, additional, total,

Topics {✒}

de/apps/zmf/mirwalk/index increased bace1/beta-secretase expression open access article pri-mirna post-transcriptional editing microrna cluster mir-29a/b-1 article download pdf joint genome-wide profiling sh-sy5y neuroblastoma cells cold phosphate-buffered saline high-throughput sequencing technologies hif-1alpha/hif-1beta mouse nih-3t3 cells small-rna sequencing datasets 3’-biotin-5’-isomir-101 versus 3’-biotin-mir-101 differentiated sh-sy5y cells anti-flag antibody shows sh-sy5y cells decreased specific rt-qpcr assays negative post-transcriptional regulators rna-induced silencing complex high-throughput sequencing data sh-sy5y-ago2-flag transfected sh-sy5y cells sh-sy5y cells transfected nyap2 expression anti-correlated scn3b expression anti-correlated candidate age-related genes modulating age-related genes d-ago2 crossing thresholds mir-101-sequence-gene pair predicted polymerase activation/denaturation cycle deserves specific research de hoon mj ja del río specific rt-qpcrs determinations eulàlia martí article llorens mirna/mrna binding leads micrornas en route ja de río small rnas datasets isomir-dependent differential output control d-ago2 antibody xavier estivill coding regulatory rnas reveals argonaute association sh-sy5y cells privacy choices/manage cookies amyloid precursor protein universitat de barcelona

Questions {❓}

  • Filipowicz W, Bhattacharyya SN, Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

Schema {đŸ—ș}

WebPage:
      mainEntity:
         headline:A highly expressed miR-101 isomiR is a functional silencing small RNA
         description:MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterogeneity at length and sequence level for the majority of mature miRNAs (IsomiRs). Most isomiRs can be explained by variability in either Dicer1 or Drosha cleavage during miRNA biogenesis at 5’ or 3’ of the miRNA (trimming variants). Although isomiRs have been described in different tissues and organisms, their functional validation as modulators of gene expression remains elusive. Here we have characterized the expression and function of a highly abundant miR-101 5’-trimming variant (5’-isomiR-101). The analysis of small RNA sequencing data in several human tissues and cell lines indicates that 5’-isomiR-101 is ubiquitously detected and a highly abundant, especially in the brain. 5’-isomiR-101 was found in Ago-2 immunocomplexes and complementary approaches showed that 5’-isomiR-101 interacted with different members of the silencing (RISC) complex. In addition, 5’-isomiR-101 decreased the expression of five validated miR-101 targets, suggesting that it is a functional variant. Both the binding to RISC members and the degree of silencing were less efficient for 5’-isomiR-101 compared with miR-101. For some targets, both miR-101 and 5’-isomiR-101 significantly decreased protein expression with no changes in the respective mRNA levels. Although a high number of overlapping predicted targets suggest similar targeted biological pathways, a correlation analysis of the expression profiles of miR-101 variants and predicted mRNA targets in human brains at different ages, suggest specific functions for miR-101- and 5’-isomiR-101. These results suggest that isomiRs are functional variants and further indicate that for a given miRNA, the different isomiRs may contribute to the overall effect as quantitative and qualitative fine-tuners of gene expression.
         datePublished:2013-02-15T00:00:00Z
         dateModified:2013-02-15T00:00:00Z
         pageStart:1
         pageEnd:14
         license:https://creativecommons.org/licenses/by/2.0
         sameAs:https://doi.org/10.1186/1471-2164-14-104
         keywords:
            MicroRNA
            miR-101
            IsomiR
            Ultra-sequencing
            Deep-sequencing
            Life Sciences
            general
            Microarrays
            Proteomics
            Animal Genetics and Genomics
            Microbial Genetics and Genomics
            Plant Genetics and Genomics
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                        name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
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                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
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                        name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
                        type:PostalAddress
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                     address:
                        name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:University of Barcelona (UB)
                     address:
                        name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
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                        name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
                        type:PostalAddress
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                     name:IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona
                     address:
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                        name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
                        type:PostalAddress
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                     address:
                        name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
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                     type:Organization
                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
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                        name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
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                        name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Universitat Pompeu Fabra (UPF)
                     address:
                        name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
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ScholarlyArticle:
      headline:A highly expressed miR-101 isomiR is a functional silencing small RNA
      description:MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterogeneity at length and sequence level for the majority of mature miRNAs (IsomiRs). Most isomiRs can be explained by variability in either Dicer1 or Drosha cleavage during miRNA biogenesis at 5’ or 3’ of the miRNA (trimming variants). Although isomiRs have been described in different tissues and organisms, their functional validation as modulators of gene expression remains elusive. Here we have characterized the expression and function of a highly abundant miR-101 5’-trimming variant (5’-isomiR-101). The analysis of small RNA sequencing data in several human tissues and cell lines indicates that 5’-isomiR-101 is ubiquitously detected and a highly abundant, especially in the brain. 5’-isomiR-101 was found in Ago-2 immunocomplexes and complementary approaches showed that 5’-isomiR-101 interacted with different members of the silencing (RISC) complex. In addition, 5’-isomiR-101 decreased the expression of five validated miR-101 targets, suggesting that it is a functional variant. Both the binding to RISC members and the degree of silencing were less efficient for 5’-isomiR-101 compared with miR-101. For some targets, both miR-101 and 5’-isomiR-101 significantly decreased protein expression with no changes in the respective mRNA levels. Although a high number of overlapping predicted targets suggest similar targeted biological pathways, a correlation analysis of the expression profiles of miR-101 variants and predicted mRNA targets in human brains at different ages, suggest specific functions for miR-101- and 5’-isomiR-101. These results suggest that isomiRs are functional variants and further indicate that for a given miRNA, the different isomiRs may contribute to the overall effect as quantitative and qualitative fine-tuners of gene expression.
      datePublished:2013-02-15T00:00:00Z
      dateModified:2013-02-15T00:00:00Z
      pageStart:1
      pageEnd:14
      license:https://creativecommons.org/licenses/by/2.0
      sameAs:https://doi.org/10.1186/1471-2164-14-104
      keywords:
         MicroRNA
         miR-101
         IsomiR
         Ultra-sequencing
         Deep-sequencing
         Life Sciences
         general
         Microarrays
         Proteomics
         Animal Genetics and Genomics
         Microbial Genetics and Genomics
         Plant Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-2164-14-104/MediaObjects/12864_2012_Article_5252_Fig1_HTML.jpg
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-2164-14-104/MediaObjects/12864_2012_Article_5252_Fig3_HTML.jpg
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         name:BMC Genomics
         issn:
            1471-2164
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            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Franc Llorens
            affiliation:
                  name:Institut de Bioenginyeria de Catalunya (IBEC)
                  address:
                     name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:University of Barcelona (UB)
                  address:
                     name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
                  address:
                     name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:MĂłnica Bañez-Coronel
            affiliation:
                  name:Centre for Genomic Regulation (CRG) and UPF
                  address:
                     name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Pompeu Fabra (UPF)
                  address:
                     name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
                  address:
                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lorena Pantano
            affiliation:
                  name:Institut de Medicina Predictiva i Personalitzada del CĂ ncer
                  address:
                     name:Institut de Medicina Predictiva i Personalitzada del CĂ ncer, Badalona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jose Antonio del RĂ­o
            affiliation:
                  name:Institut de Bioenginyeria de Catalunya (IBEC)
                  address:
                     name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:University of Barcelona (UB)
                  address:
                     name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
                  address:
                     name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Isidre Ferrer
            affiliation:
                  name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
                  address:
                     name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona
                  address:
                     name:Institut Neuropatologia, Servei Anatomia PatolĂČgica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xavier Estivill
            affiliation:
                  name:Centre for Genomic Regulation (CRG) and UPF
                  address:
                     name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Pompeu Fabra (UPF)
                  address:
                     name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
                  address:
                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:EulĂ lia MartĂ­
            affiliation:
                  name:Centre for Genomic Regulation (CRG) and UPF
                  address:
                     name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Pompeu Fabra (UPF)
                  address:
                     name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
                  address:
                     name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
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      name:University of Barcelona (UB)
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         name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
         type:PostalAddress
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         name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
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      name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
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         name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
         type:PostalAddress
      name:Institut de Medicina Predictiva i Personalitzada del CĂ ncer
      address:
         name:Institut de Medicina Predictiva i Personalitzada del CĂ ncer, Badalona, Spain
         type:PostalAddress
      name:Institut de Bioenginyeria de Catalunya (IBEC)
      address:
         name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
         type:PostalAddress
      name:University of Barcelona (UB)
      address:
         name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
         type:PostalAddress
      name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
      address:
         name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
         type:PostalAddress
      name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED)
      address:
         name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
         type:PostalAddress
      name:IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona
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         name:Institut Neuropatologia, Servei Anatomia PatolĂČgica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:Centre for Genomic Regulation (CRG) and UPF
      address:
         name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
         type:PostalAddress
      name:Universitat Pompeu Fabra (UPF)
      address:
         name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
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               name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
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            name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP)
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      name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
      name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
      name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
      name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
      name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
      name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
      name:Institut de Medicina Predictiva i Personalitzada del CĂ ncer, Badalona, Spain
      name:Molecular and Cellular Neurobiotechnology Group, Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain
      name:Department of Cell Biology, University of Barcelona (UB), Barcelona, Spain
      name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
      name:Network Biomedical Research Center for Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
      name:Institut Neuropatologia, Servei Anatomia PatolĂČgica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain
      name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
      name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
      name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain
      name:Genetic Causes of Disease Group, Genes and Disease Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain
      name:Universitat Pompeu Fabra (UPF), Barcelona, Spain
      name:Centro de InvestigaciĂłn BiomĂ©dica en Red de EpidemiologĂ­a y Salud PĂșblica, (CIBERESP), Barcelona, Spain

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