We are analyzing https://link.springer.com/article/10.1186/1471-213x-3-11.

Title:
Knockout of ERK5 causes multiple defects in placental and embryonic development | BMC Developmental Biology
Description:
Backgroud ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. Results To help determine the function of ERK5 we have used gene targeting to inactivate this gene in mice. Here we report that ERK5 knockout mice die at approximately E10.5. In situ hybridisation for ERK5, and its upstream activator MKK5, showed strong expression in the head and trunk of the embryo at this stage of development. Between E9.5 and E10.5, multiple developmental problems are seen in the ERK5-/- embryos, including an increase in apoptosis in the cephalic mesenchyme tissue, abnormalities in the hind gut, as well as problems in vascular remodelling, cardiac development and placental defects. Conclusion Erk5 is essential for early embryonic development, and is required for normal development of the vascular system and cell survival.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

erk, embryos, pubmed, type, wild, development, article, google, scholar, cas, expression, knockout, cephalic, mesenchyme, blood, mice, fig, embryonic, kinase, heart, vessels, sections, placental, protein, cells, cell, figure, head, mkk, showed, problems, region, placentas, analysis, cardiac, biol, authors, embryo, apoptosis, reported, knockouts, compared, central, defects, full, role, gene, situ, angiogenesis, size,

Topics {✒️}

mitogen-activated protein kinase adapter protein lad/ribp article download pdf thr-xaa-tyr motif protein kinase erk5/bmk1 open access license mapk kinase kinase normal post-natal growth epidermal growth factor strain-independent postnatal neurodegeneration intraplacental yolk sac/sinus oxidative stress-mediated activation mek1-deficient mice reveals kinase inhibitors pd184352 full size image thymidine kinase cassette p38alpha map kinase mek5-bmk1/erk5 pathway ventricular muscle-restricted targeting authors’ original file redox-sensitive kinase yolk sacs separated cell proliferation induced privacy choices/manage cookies chorionic plate erk5-/- yolk sacs map kinase p38 full access related subjects receptor tyrosine kinases developmental biology mekk2 activate mkk5 erk1/2 kinase activation metastatic prostate cancer stress-induced phosphorylation upstream kinase mkk5 article yan transcription factor mef2c rxralpha gene reveals smooth muscle cells general growth retardation large blood vessels early embryonic development neuregulin signal transduction positive cell lines temporally specific pattern trophoblast-specific cdna negative selection marker dominant negative effect erk5-/- mutant yolk

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Knockout of ERK5 causes multiple defects in placental and embryonic development
         description:ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. To help determine the function of ERK5 we have used gene targeting to inactivate this gene in mice. Here we report that ERK5 knockout mice die at approximately E10.5. In situ hybridisation for ERK5, and its upstream activator MKK5, showed strong expression in the head and trunk of the embryo at this stage of development. Between E9.5 and E10.5, multiple developmental problems are seen in the ERK5-/- embryos, including an increase in apoptosis in the cephalic mesenchyme tissue, abnormalities in the hind gut, as well as problems in vascular remodelling, cardiac development and placental defects. Erk5 is essential for early embryonic development, and is required for normal development of the vascular system and cell survival.
         datePublished:2003-12-16T00:00:00Z
         dateModified:2003-12-16T00:00:00Z
         pageStart:1
         pageEnd:21
         sameAs:https://doi.org/10.1186/1471-213X-3-11
         keywords:
            Wild Type Embryo
            Placental Development
            ERK5 Protein
            Chorionic Plate
            Mitogen Activate Protein Kinase Kinase Kinase
            Developmental Biology
            Animal Models
            Life Sciences
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig6_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig7_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig8_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig9_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig10_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig11_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig12_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig13_HTML.jpg
         isPartOf:
            name:BMC Developmental Biology
            issn:
               1471-213X
            volumeNumber:3
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Lijun Yan
               affiliation:
                     name:University of Dundee
                     address:
                        name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julia Carr
               affiliation:
                     name:University of Dundee
                     address:
                        name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter R Ashby
               affiliation:
                     name:University of Dundee
                     address:
                        name:Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Victoria Murry-Tait
               affiliation:
                     name:University of Dundee
                     address:
                        name:Faculty of Life Sciences, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Calum Thompson
               affiliation:
                     name:University of Dundee
                     address:
                        name:CHIPS, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J Simon C Arthur
               affiliation:
                     name:University of Dundee
                     address:
                        name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Knockout of ERK5 causes multiple defects in placental and embryonic development
      description:ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. To help determine the function of ERK5 we have used gene targeting to inactivate this gene in mice. Here we report that ERK5 knockout mice die at approximately E10.5. In situ hybridisation for ERK5, and its upstream activator MKK5, showed strong expression in the head and trunk of the embryo at this stage of development. Between E9.5 and E10.5, multiple developmental problems are seen in the ERK5-/- embryos, including an increase in apoptosis in the cephalic mesenchyme tissue, abnormalities in the hind gut, as well as problems in vascular remodelling, cardiac development and placental defects. Erk5 is essential for early embryonic development, and is required for normal development of the vascular system and cell survival.
      datePublished:2003-12-16T00:00:00Z
      dateModified:2003-12-16T00:00:00Z
      pageStart:1
      pageEnd:21
      sameAs:https://doi.org/10.1186/1471-213X-3-11
      keywords:
         Wild Type Embryo
         Placental Development
         ERK5 Protein
         Chorionic Plate
         Mitogen Activate Protein Kinase Kinase Kinase
         Developmental Biology
         Animal Models
         Life Sciences
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig6_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig7_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig8_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig9_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig10_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig11_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig12_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1471-213X-3-11/MediaObjects/12861_2003_Article_35_Fig13_HTML.jpg
      isPartOf:
         name:BMC Developmental Biology
         issn:
            1471-213X
         volumeNumber:3
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Lijun Yan
            affiliation:
                  name:University of Dundee
                  address:
                     name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julia Carr
            affiliation:
                  name:University of Dundee
                  address:
                     name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter R Ashby
            affiliation:
                  name:University of Dundee
                  address:
                     name:Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Victoria Murry-Tait
            affiliation:
                  name:University of Dundee
                  address:
                     name:Faculty of Life Sciences, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Calum Thompson
            affiliation:
                  name:University of Dundee
                  address:
                     name:CHIPS, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J Simon C Arthur
            affiliation:
                  name:University of Dundee
                  address:
                     name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:BMC Developmental Biology
      issn:
         1471-213X
      volumeNumber:3
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Dundee
      address:
         name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
         type:PostalAddress
      name:University of Dundee
      address:
         name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
         type:PostalAddress
      name:University of Dundee
      address:
         name:Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
         type:PostalAddress
      name:University of Dundee
      address:
         name:Faculty of Life Sciences, University of Dundee, Dundee, UK
         type:PostalAddress
      name:University of Dundee
      address:
         name:CHIPS, University of Dundee, Dundee, UK
         type:PostalAddress
      name:University of Dundee
      address:
         name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Lijun Yan
      affiliation:
            name:University of Dundee
            address:
               name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      name:Julia Carr
      affiliation:
            name:University of Dundee
            address:
               name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      name:Peter R Ashby
      affiliation:
            name:University of Dundee
            address:
               name:Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      name:Victoria Murry-Tait
      affiliation:
            name:University of Dundee
            address:
               name:Faculty of Life Sciences, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      name:Calum Thompson
      affiliation:
            name:University of Dundee
            address:
               name:CHIPS, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      name:J Simon C Arthur
      affiliation:
            name:University of Dundee
            address:
               name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
      name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
      name:Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
      name:Faculty of Life Sciences, University of Dundee, Dundee, UK
      name:CHIPS, University of Dundee, Dundee, UK
      name:MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK

External Links {🔗}(198)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Knockout.js
Prism.js

CDN Services {📦}

Crossref

4.9s.

LINK . SPRINGER . COM {}