We are analyzing https://link.springer.com/article/10.1186/1471-213x-11-21.

Title:
The zebrafish heart regenerates after cryoinjury-induced myocardial infarction | BMC Developmental Biology
Description:
Background In humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele amphibians are capable of heart regeneration after a partial amputation. However, due to the lack of a suitable infarct model, it is not known how these animals respond to myocardial infarction. Results Here, we have established a heart infarct model in zebrafish using cryoinjury. In contrast to the common method of partial resection, cryoinjury results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts. As in mammals, the initial stages of the injury response include thrombosis, accumulation of fibroblasts and collagen deposition. However, at later stages, cardiac cells can enter the cell cycle and invade the infarct area in zebrafish. In the subsequent two months, fibrotic scar tissue is progressively eliminated by cell apoptosis and becomes replaced with a new myocardium, resulting in scarless regeneration. We show that tissue remodeling at the myocardial-infarct border zone is associated with accumulation of Vimentin-positive fibroblasts and with expression of an extracellular matrix protein Tenascin-C. Electrocardiogram analysis demonstrated that the reconstitution of the cardiac muscle leads to the restoration of the heart function. Conclusions We developed a new cryoinjury model to induce myocardial infarction in zebrafish. Although the initial stages following cryoinjury resemble typical healing in mammals, the zebrafish heart is capable of structural and functional regeneration. Understanding the key healing processes after myocardial infarction in zebrafish may result in identification of the barriers to efficient cardiac regeneration in mammals.
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Keywords {🔍}

heart, pubmed, article, dpci, zebrafish, regeneration, myocardium, cell, figure, google, scholar, cells, cas, cardiomyocytes, tissue, cardiac, myocardial, postinfarct, cryoinjury, infarct, ventricular, infarction, ventricle, scar, wall, area, file, injury, collagen, fibroblasts, hearts, tnc, fish, proliferation, sections, additional, fibrin, apoptosis, zone, blue, central, analysis, resection, matrix, cardiomyocyte, time, size, detected, red, authors,

Topics {✒️}

mcm5/dsred2-nuc-positive nuclei relative open access article brdu-cell-proliferation assay demonstrated goat anti-rabbit cy5 dsred2-nuc/mcm5-positive nuclei van luyn mj article download pdf reveals fibroblast-cardiomyocyte coupling jim jung-ching lin possesses counter-adhesive properties de-adhesive ecm protein cmlc-2 cardiomyocyte-specific promoter anti-digoxigenin fluorescein conjugated protease-rich environment leading tnc counter-adhesive domains cardiac-specific cmlc-2 promoter mcm5/dsred-positive cells massive cell death quadruple-stained cross-sections anti-vimentin antibodies react full size image α-sma-positive cells terminal transferase post-infarct zone extends apical-lateral ventricular wall heart cross-sections stained fibrin-based provisional matrix cryoinjury-induced myocardial infarction digoxigenin-dutp solution article chablais related subjects large disk-shaped damage cardiovascular regeneration damaged tpm-positive myocardium privacy choices/manage cookies anna jaźwińska vim/tnc-expressing cells intermediate filament protein remaining post-infarct region rabbit anti-mcm5 myocardial-infarct border zone post-infarct area decreased authors’ original file rabbit anti-mef-2 enhanced cardiomyocyte proliferation dsred2-positive nuclei complete myocardial regeneration trigger cardiomyocyte proliferation full access cell-cycle entry

Questions {❓}

Borchardt T, Braun T: Cardiovascular regeneration in non-mammalian model systems: what are the differences between newts and man?

Schema {🗺️}

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         headline:The zebrafish heart regenerates after cryoinjury-induced myocardial infarction
         description:In humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele amphibians are capable of heart regeneration after a partial amputation. However, due to the lack of a suitable infarct model, it is not known how these animals respond to myocardial infarction. Here, we have established a heart infarct model in zebrafish using cryoinjury. In contrast to the common method of partial resection, cryoinjury results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts. As in mammals, the initial stages of the injury response include thrombosis, accumulation of fibroblasts and collagen deposition. However, at later stages, cardiac cells can enter the cell cycle and invade the infarct area in zebrafish. In the subsequent two months, fibrotic scar tissue is progressively eliminated by cell apoptosis and becomes replaced with a new myocardium, resulting in scarless regeneration. We show that tissue remodeling at the myocardial-infarct border zone is associated with accumulation of Vimentin-positive fibroblasts and with expression of an extracellular matrix protein Tenascin-C. Electrocardiogram analysis demonstrated that the reconstitution of the cardiac muscle leads to the restoration of the heart function. We developed a new cryoinjury model to induce myocardial infarction in zebrafish. Although the initial stages following cryoinjury resemble typical healing in mammals, the zebrafish heart is capable of structural and functional regeneration. Understanding the key healing processes after myocardial infarction in zebrafish may result in identification of the barriers to efficient cardiac regeneration in mammals.
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            Cardiomyocyte Proliferation
            Massive Cell Death
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            Developmental Biology
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            Life Sciences
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      headline:The zebrafish heart regenerates after cryoinjury-induced myocardial infarction
      description:In humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele amphibians are capable of heart regeneration after a partial amputation. However, due to the lack of a suitable infarct model, it is not known how these animals respond to myocardial infarction. Here, we have established a heart infarct model in zebrafish using cryoinjury. In contrast to the common method of partial resection, cryoinjury results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts. As in mammals, the initial stages of the injury response include thrombosis, accumulation of fibroblasts and collagen deposition. However, at later stages, cardiac cells can enter the cell cycle and invade the infarct area in zebrafish. In the subsequent two months, fibrotic scar tissue is progressively eliminated by cell apoptosis and becomes replaced with a new myocardium, resulting in scarless regeneration. We show that tissue remodeling at the myocardial-infarct border zone is associated with accumulation of Vimentin-positive fibroblasts and with expression of an extracellular matrix protein Tenascin-C. Electrocardiogram analysis demonstrated that the reconstitution of the cardiac muscle leads to the restoration of the heart function. We developed a new cryoinjury model to induce myocardial infarction in zebrafish. Although the initial stages following cryoinjury resemble typical healing in mammals, the zebrafish heart is capable of structural and functional regeneration. Understanding the key healing processes after myocardial infarction in zebrafish may result in identification of the barriers to efficient cardiac regeneration in mammals.
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         Heart Regeneration
         Cardiomyocyte Proliferation
         Massive Cell Death
         Zebrafish Heart
         Developmental Biology
         Animal Models
         Life Sciences
         general
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