We are analyzing https://link.springer.com/article/10.1186/1471-2121-7-4.

Title:
Wnt signaling induces epithelial differentiation during cutaneous wound healing | BMC Molecular and Cell Biology
Description:
Background Cutaneous wound repair in adult mammals does not regenerate the original epithelial architecture and results in altered skin function. We propose that lack of regeneration may be due to the absence of appropriate molecular signals to promote regeneration. In this study, we investigated the regulation of Wnt signaling during cutaneous wound healing and the consequence of activating either the beta-catenin-dependent or beta-catenin-independent Wnt signaling on epidermal architecture during wound repair. Results We determined that the expression of Wnt ligands that typically signal via the beta-catenin-independent pathway is up-regulated in the wound while the beta-catenin-dependent Wnt signaling is activated in the hair follicles adjacent to the wound edge. Ectopic activation of beta-catenin-dependent Wnt signaling with lithium chloride in the wound resulted in epithelial cysts and occasional rudimentary hair follicle structures within the epidermis. In contrast, forced expression of Wnt-5a in the deeper wound induced changes in the interfollicular epithelium mimicking regeneration, including formation of epithelia-lined cysts in the wound dermis, rudimentary hair follicles and sebaceous glands, without formation of tumors. Conclusion These findings suggest that adult interfollicular epithelium is capable of responding to Wnt morphogenic signals necessary for restoring epithelial tissue patterning in the skin during wound repair.
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Keywords {🔍}

wound, wnt, skin, epithelial, hair, article, mice, pubmed, wounds, signaling, cells, expression, google, scholar, wnta, cas, pathway, cell, adult, normal, control, βcatenindependent, healing, activation, day, follicles, follicle, time, cutaneous, development, stem, βcatenin, retroviral, formation, tissue, βcateninindependent, days, repair, regeneration, epithelium, pmxwnta, cysts, signals, dermis, sebaceous, glands, activity, treated, original, topgal,

Topics {✒️}

pe-conjugated anti-cd5 antibody glycogen synthase kinase-3β pe-labeled anti-cd5 antibody β-catenin-dependent pathway depending β-catenin-independent signaling pathway β-catenin-dependent signaling shows inserted full-length wnt-5a mapping wnt/beta-catenin signaling β-catenin-independent wnt signaling beta-catenin-independent wnt signaling β-catenin-dependent wnt signaling β-catenin-dependent wnt pathway beta-catenin-dependent wnt signaling β-catenin-dependent pathway resulted beta-catenin signalling anti-β-catenin antibody activate β-catenin-independent signaling β-catenin/tcf-responsive promoter [13] open access article β-catenin-independent signaling β-catenin-independent pathway β-catenin-dependent signaling β-catenin-dependent signaling [12] sebaceous gland formation beta-catenin-independent pathway β-catenin-dependent pathway β-catenin dependent pathway β-catenin-dependent pathway [14] free cytosolic β-catenin β-catenin favored differentiation liquid nitrogen-cooled mortar β-galactosidase activity compared β-galactosidase reporter gene wnt signalling robust β-gal activity β-gal activity compared article download pdf β-catenin-independent wnts anterior-posterior axis formation bone marrow-derived cells high-efficiency gene transfer β-gal activity detected pmxwnt-5a treated wounds brian kim pre-selected wnt genes transparent semi-occlusive dressing pmxwnt-5a treated mice wnt-5a treated wounds collagen-rich dermal matrix male c57bl/6j mice

Questions {❓}

Korbling M, Estrov Z: Adult stem cells for tissue repair - a new therapeutic concept?
The histology of the observed cysts is similar to that seen in the ?

Schema {🗺️}

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         description:Cutaneous wound repair in adult mammals does not regenerate the original epithelial architecture and results in altered skin function. We propose that lack of regeneration may be due to the absence of appropriate molecular signals to promote regeneration. In this study, we investigated the regulation of Wnt signaling during cutaneous wound healing and the consequence of activating either the beta-catenin-dependent or beta-catenin-independent Wnt signaling on epidermal architecture during wound repair. We determined that the expression of Wnt ligands that typically signal via the beta-catenin-independent pathway is up-regulated in the wound while the beta-catenin-dependent Wnt signaling is activated in the hair follicles adjacent to the wound edge. Ectopic activation of beta-catenin-dependent Wnt signaling with lithium chloride in the wound resulted in epithelial cysts and occasional rudimentary hair follicle structures within the epidermis. In contrast, forced expression of Wnt-5a in the deeper wound induced changes in the interfollicular epithelium mimicking regeneration, including formation of epithelia-lined cysts in the wound dermis, rudimentary hair follicles and sebaceous glands, without formation of tumors. These findings suggest that adult interfollicular epithelium is capable of responding to Wnt morphogenic signals necessary for restoring epithelial tissue patterning in the skin during wound repair.
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