We are analyzing https://link.springer.com/article/10.1007/s40520-013-0190-y.

Title:
Age-associated aberrations in mouse cellular and humoral immune responses | Aging Clinical and Experimental Research
Description:
Background and aims Several contradictions and inconsistent reports regarding nature of dysfunction of immune system with age are known. The lack of multipoint age comparisons in immune functions contributes to the observed ambiguity in understanding immunosenescence. Thus, the present study aimed at a concurrent analysis of different immune cells in an attempt to delineate the nature of dysregulation with progressive aging in mice. Methods 4, 8, 12 and 16 months old mice were analyzed for various immune parameters involving neutrophils, peripheral blood lymphocytes, peritoneal macrophages, splenocytes, inflamm-aging markers in plasma and humoral immune response in intestine. Results Neutrophils registered a remarkable decrease in activities of respiratory burst enzymes and phagocytosis, while macrophages recorded a decrease in TLR-2 and TLR-4 expression. MCP-1 and CRP levels increased in plasma, whereas stimulation index and CD28 expression decreased in lymphocytes. Interleukins analysis (IFN-γ, IL-4, IL-10) showed a remarkable shift towards Th2 response which further resulted in increased IgG1/IgG2a ratio and IgE levels in intestine. Conclusion A decline in cell-mediated immune response, chronic inflammation and aggravation of humoral immunity was evident which conclusively suggests a skewed Th2 pathway during aging.
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article, pubmed, google, scholar, cas, aging, ageing, immunol, immune, central, cells, human, kapila, mice, clin, exp, function, content, research, levels, elderly, neutrophil, mech, dev, privacy, cookies, ageassociated, cellular, humoral, immunosenescence, neutrophils, response, access, cell, publish, search, sharma, nature, lymphocytes, decrease, tlr, expression, rev, res, gerontol, analysis, data, information, log, journal,

Topics {✒️}

month download article/chapter meena kapasiya & suman kapila increased igg1/igg2a ratio cell-mediated immune response de ruiz-holgado ap cell subset-specific susceptibility cd8high + cd28 + cd57 − cells age-related inflammatory cytokines article aging clinical full article pdf humoral immune responses humoral immune response privacy choices/manage cookies experimental research aims inflamm-aging markers de macias men article sharma th1-th2 shift peripheral blood lymphocytes crp levels increased skewed th2 pathway immune functions contributes human polymorphonuclear leucocytes humoral immunity neutrophil respiratory burst shearer gm anti-immunosenescence agents european economic area acute respiratory illness salmonella enteritidis infection rapid colorimetric assay extracellular matrix proteins van duin f-tresguerres ja express surface markers financial assistance provided polymorphonuclear neutrophil leukocytes conditions privacy policy serum immunoglobulin levels aging affects initiation probiotic lactobacillus acidophilus early activation events martínez-gonzález ma respiratory burst enzymes peritoneal leukocytes relate low-grade inflammation accepting optional cookies multipoint age comparisons age-dependent alterations aging population ageing

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