We are analyzing https://link.springer.com/article/10.1007/s40268-015-0102-z.

Title:
Molecular Insight in the Multifunctional Effects of Oridonin | Drugs in R&D
Description:
Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases by exerting anti-tumor, anti-inflammatory, pro-apoptotic, and neurological effects. Unfortunately, the mechanisms via which oridonin exerts these effects remain poorly understood. This review provides an overview of the multifunctional effects of oridonin as well as the reasons for its potential for investigations in the treatment of many diseases other than cancer.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

oridonin, pubmed, google, scholar, cells, cas, article, apoptosis, cancer, cell, wang, zhang, human, liu, effects, protein, reported, ikejima, tashiro, onodera, signaling, pathways, expression, oridonininduced, chen, activity, med, effect, autophagy, int, activation, pathway, induces, induced, treatment, kinase, apoptotic, huang, potential, table, pharm, yang, rabdosia, mechanism, growth, central, pharmacol, molecular, rubescens, inhibition,

Topics {✒️}

c-met-nuclear factor-kappab-cyclooxygenase-2 nf-kappab-cox-2-il-1beta pathway high-speed counter-current chromatography ras-raf-erk signaling pathways c-jun n-terminal kinase extracellular signal-regulated kinase-dependent suppressing wnt/beta-catenin signaling nf-kappa b-inhibiting capacity comparative toxicogenomics database lipopolysaccharide-stimulated nf-kappa activity attenuating b-amyloid deposition b-cell activating factor upstream regulator i-kappa extracellular signal-regulated kinase nanostructured lipid carriers mapk-dependent cell death c-met-bcl-2-caspase-3 pathways suppressing th1/th17 simultaneously article download pdf extracelluar-signal regulated kinase augment oridonin-induced efferocytosis assembled mpeg-pcl micelles serine/threonine kinase receptor adult t-cell leukemia anti-cancer pharmacological properties nitrogen-enriched oridonin analogues synergetic anti-leukemia effect top interacting genes thiazole-fused a-ring microemulsifying drug-delivery system c-met promoted apoptosis oridonin-induced autophagic process activating caspase-3/icad pathway lyn/mtor signaling pathway oridonin-loaded nanoparticles coated cyclin b1/p-cdc2 phosphatidylinositol 3-kinase-independent pathway modulates th1/th2 balance protecting group-free synthesis mapk-p38 signaling pathway nrf2-mediated defensive response g2/m-arresting effects multi-targeted effects remains brice ayissi owona oridonin-induced hepg2 apoptosis reactive oxygen species ros-mediated signaling pathways anti-apoptotic protein bcl-2 hepatic stellate cells pro-apoptotic proteins bax

Schema {🗺️}

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         description:Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases by exerting anti-tumor, anti-inflammatory, pro-apoptotic, and neurological effects. Unfortunately, the mechanisms via which oridonin exerts these effects remain poorly understood. This review provides an overview of the multifunctional effects of oridonin as well as the reasons for its potential for investigations in the treatment of many diseases other than cancer.
         datePublished:2015-08-20T00:00:00Z
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      headline:Molecular Insight in the Multifunctional Effects of Oridonin
      description:Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases by exerting anti-tumor, anti-inflammatory, pro-apoptotic, and neurological effects. Unfortunately, the mechanisms via which oridonin exerts these effects remain poorly understood. This review provides an overview of the multifunctional effects of oridonin as well as the reasons for its potential for investigations in the treatment of many diseases other than cancer.
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         Internal Medicine
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      name:Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tübingen, Tübingen, Germany

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