We are analyzing https://link.springer.com/article/10.1007/s40200-021-00911-2.

Title:
Role of ferritin and oxidative stress index in gestational diabetes mellitus | Journal of Diabetes & Metabolic Disorders
Description:
To investigate the role of serum ferritin and oxidative stress in the development of GDM and to assess their relationship with the ensuing hyperglycemia. A case–control study was carried on 90 non-anemic pregnant women of 20–40 years with a gestation of 24–28 weeks. Study group (n = 65) was identified according to the Diabetes in Pregnancy Study Group India (DIPSI) criteria (2-h plasma glucose ≥ 140 mg/dl) and controls (n = 25) having 2-h plasma glucose < 120 mg/dl. DIPSI 2-h plasma glucose, HbA1c and serum ferritin were measured and oxidative stress index (OSI) was calculated. Statistical tests were performed using SPSS version 25.0. Pre-pregnancy BMI showed a significant difference between control and study group. DIPSI 2 h blood glucose, HbA1c, serum ferritin and OSI were significantly higher in study group compared to control group. Both 2 h blood glucose and HbA1c were positively correlated with serum ferritin and OSI, serum ferritin and OSI were also positively correlated with each other. Higher pre-pregnancy BMI elevates serum ferritin, which in turn increases the OSI. Both ferritin and oxidative stress raises 2 h blood glucose and HbA1c in GDM patients possibly by causing in-vivo pancreatic β –cell injury and death (ferroptosis). Serum ferritin and OSI could become newer personalized theranostic and monitoring targets in overweight/obese pregnant females especially GDM patients.
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month download article/chapter ferroptosis-inducing agents compromise hif-1α/ho-1 pathway related subjects large-scale cellular death diabetes-induced endothelial dysfunction plasma glucose ≥ 140 mg/dl oxidative stress index jama netw open overweight/obese pregnant females gestational diabetes mellitus full article pdf serum ferritin level feroz alam feroz alam privacy choices/manage cookies quercetin alleviates ferroptosis db/db mice oxidative stress biomarkers author correspondence check access instant access pancreatic β cells idf diabetes atlas diabetes dev ctries retrospective multicenter study clin exp med beta-cell apoptosis additional information publisher' study group compared insulin responsive element reduced antioxidant capacity cell death dis acta med iran pak med assoc case–control study case-control study prepubescent obese children european economic area newer personalized theranostic prevailing covid-19 pandemic hauguel-de mouzon total antioxidant status total oxidant status body fat distribution mexican american men nutrition examination survey systems biology understanding article gautam mol asp med

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         description:To investigate the role of serum ferritin and oxidative stress in the development of GDM and to assess their relationship with the ensuing hyperglycemia. A case–control study was carried on 90 non-anemic pregnant women of 20–40 years with a gestation of 24–28 weeks. Study group (n = 65) was identified according to the Diabetes in Pregnancy Study Group India (DIPSI) criteria (2-h plasma glucose ≥ 140 mg/dl) and controls (n = 25) having 2-h plasma glucose < 120 mg/dl. DIPSI 2-h plasma glucose, HbA1c and serum ferritin were measured and oxidative stress index (OSI) was calculated. Statistical tests were performed using SPSS version 25.0. Pre-pregnancy BMI showed a significant difference between control and study group. DIPSI 2 h blood glucose, HbA1c, serum ferritin and OSI were significantly higher in study group compared to control group. Both 2 h blood glucose and HbA1c were positively correlated with serum ferritin and OSI, serum ferritin and OSI were also positively correlated with each other. Higher pre-pregnancy BMI elevates serum ferritin, which in turn increases the OSI. Both ferritin and oxidative stress raises 2 h blood glucose and HbA1c in GDM patients possibly by causing in-vivo pancreatic β –cell injury and death (ferroptosis). Serum ferritin and OSI could become newer personalized theranostic and monitoring targets in overweight/obese pregnant females especially GDM patients.
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      headline:Role of ferritin and oxidative stress index in gestational diabetes mellitus
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         Oxidative Stress Index
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         Endocrinology
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