We are analyzing https://link.springer.com/article/10.1007/s40139-013-0035-6.

Title:
Cancer Stem Cells Under Hypoxia as a Chemoresistance Factor in the Breast and Brain | Current Pathobiology Reports
Description:
Over the last 15 years, basic science and clinical studies have been conducted to identify cancer stem cells (CSCs) in several types of cancer to reveal their mechanistic involvement in cancer recurrence for therapeutic exploitation. Exposure of cancer cells and tissues to hypoxia, or sub-atmospheric concentrations of oxygen (<21 % O2), stimulates a variety of stress responses that bias the cells toward a self-preserving, anti-apoptotic phenotype, properties that are found in CSCs. Despite major advances in our understanding of hypoxia, CSCs, and their interrelated nature, some of the most promising cancer therapy has been of limited clinical efficacy, in part because of the inherently hypoxic nature of growing tumors. In this paper we discuss recent findings regarding the behavior of breast and brain CSCs under hypoxia, and the mechanisms of their chemo and/or radioresistance and metastatic potential.
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Keywords {🔍}

cancer, cells, hypoxia, pubmed, cell, google, scholar, article, cas, stem, breast, cscs, hifα, tumor, hypoxic, expression, tumors, conditions, study, factor, oxygen, therapy, human, lines, central, notch, glioblastoma, potential, metastasis, vitro, brain, resistance, gbm, cdh, response, effects, increased, gene, hif, mll, res, clinical, metastatic, factors, authors, genes, studies, involvement, mechanisms, csc,

Topics {✒️}

cd44+cd24−/low lineage− subpopulation hak-joon sung declare activating hypoxia-inducible factor-2alpha yu-shik hwang carbonic anhydrase ix hak-joon sung hypoxia-inducible factors hif-1alpha stem cell biology er-α-positive tumors correlated oxygen-dependent stress-response factors hypoxia-inducible factor-1 alpha dna-damaging stress exposures er-α-positive cells hypoxia-inducible factor 2alpha nod-scid mouse brains er-α-negative cells glioma stem cells hypoxia-inducible factor-1alpha hypoxia-inducible factor 1-dependent cancer stem cells human stem cells cancer stem cell hypoxia-induced tumor metastasis stem cell phenotypes glioblastoma stem cells low-oxygen conditions induced er-α-negative tumors multiple emt-related genes neural precursors hypoxia-induced hif expression renal carcinoma cells stem-cell markers impart stem cell estrogen receptor-alpha status renal cell carcinoma hypoxia-mediated csc phenotypes cancer cells induced csc-mediated cancer recurrence prolonged anti-vegf therapy diminished tumor-initiating capacity oxygen concentration-independent mechanism stem cell accumulation anti-angiogenic clinical therapy stem cell properties 2011 hwang-verslues primary glioma cells dedifferentiates glioma cells shrna-transfected glioblastoma cells immortalized cancer cells breast cancer cells

Schema {🗺️}

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         headline:Cancer Stem Cells Under Hypoxia as a Chemoresistance Factor in the Breast and Brain
         description:Over the last 15 years, basic science and clinical studies have been conducted to identify cancer stem cells (CSCs) in several types of cancer to reveal their mechanistic involvement in cancer recurrence for therapeutic exploitation. Exposure of cancer cells and tissues to hypoxia, or sub-atmospheric concentrations of oxygen (<21 % O2), stimulates a variety of stress responses that bias the cells toward a self-preserving, anti-apoptotic phenotype, properties that are found in CSCs. Despite major advances in our understanding of hypoxia, CSCs, and their interrelated nature, some of the most promising cancer therapy has been of limited clinical efficacy, in part because of the inherently hypoxic nature of growing tumors. In this paper we discuss recent findings regarding the behavior of breast and brain CSCs under hypoxia, and the mechanisms of their chemo and/or radioresistance and metastatic potential.
         datePublished:2014-01-11T00:00:00Z
         dateModified:2014-01-11T00:00:00Z
         pageStart:33
         pageEnd:40
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            Hypoxia
            Chemoresistance
            Metastasis
            Breast cancer
            Brain cancer
            Pathology
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ScholarlyArticle:
      headline:Cancer Stem Cells Under Hypoxia as a Chemoresistance Factor in the Breast and Brain
      description:Over the last 15 years, basic science and clinical studies have been conducted to identify cancer stem cells (CSCs) in several types of cancer to reveal their mechanistic involvement in cancer recurrence for therapeutic exploitation. Exposure of cancer cells and tissues to hypoxia, or sub-atmospheric concentrations of oxygen (<21 % O2), stimulates a variety of stress responses that bias the cells toward a self-preserving, anti-apoptotic phenotype, properties that are found in CSCs. Despite major advances in our understanding of hypoxia, CSCs, and their interrelated nature, some of the most promising cancer therapy has been of limited clinical efficacy, in part because of the inherently hypoxic nature of growing tumors. In this paper we discuss recent findings regarding the behavior of breast and brain CSCs under hypoxia, and the mechanisms of their chemo and/or radioresistance and metastatic potential.
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      dateModified:2014-01-11T00:00:00Z
      pageStart:33
      pageEnd:40
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         Cancer stem cells
         Hypoxia
         Chemoresistance
         Metastasis
         Breast cancer
         Brain cancer
         Pathology
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               type:PostalAddress
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               type:PostalAddress
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               type:PostalAddress
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               type:PostalAddress
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      name:Department of Biomedical Engineering, Vanderbilt University, Nashville, USA
      name:Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, USA
      name:Department of Biomedical Engineering, Vanderbilt University, Nashville, USA
      name:Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, USA
      name:Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, South Korea
      name:Department of Biomedical Engineering, Vanderbilt University, Nashville, USA
      name:Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, USA
      name:Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, South Korea

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