We are analyzing https://link.springer.com/article/10.1007/s13679-023-00503-6.

Title:
Short-Chain Fatty Acids—A Product of the Microbiome and Its Participation in Two-Way Communication on the Microbiome-Host Mammal Line | Current Obesity Reports
Description:
Purpose of Review The review aims to describe short-chain fatty acids (SCFAs) as metabolites of bacteria, their complex influence on whole-body metabolism, and alterations in the SCFA profile in obesity and after bariatric surgery (BS). Recent Findings The fecal profile of SCFAs in obese patients differs from that of lean patients, as well as their gut microbiota composition. In obese patients, a lower diversity of bacteria is observed, as well as higher concentrations of SCFAs in stool samples. Obesity is now considered a global epidemic and bariatric surgery (BS) is an effective treatment for severe obesity. BS affects the structure and functioning of the digestive system, and also alters gut microbiota and the concentration of fecal SCFAs. Generally, after BS, SCFA levels are lower but levels of branched short-chain fatty acids (BSCFAs) are elevated, the effect of which is not fully understood. Moreover, changes in the profile of circulating SCFAs are little known and this is an area for further research. Summary Obesity seems to be inherently associated with changes in the SCFA profile. It is necessary to better understand the impact of BS on microbiota and the metabolome in both feces and blood as only a small percentage of SCFAs are excreted. Further research may allow the development of a personalized therapeutic approach to the BS patient in terms of diet and prebiotic intervention.
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Keywords {🔍}

scfas, google, scholar, gut, butyrate, obesity, microbiota, fatty, acids, chapter, article, scfa, pubmed, shortchain, patients, fecal, acetate, metabolism, obese, effects, studies, levels, propionate, surgery, cas, diet, concentration, profile, concentrations, dietary, human, vol, higher, blood, glucose, energy, ffar, results, rygb, due, acid, intake, group, central, bariatric, impact, feces, production, shown, cells,

Topics {✒️}

high-fat diet-induced atherosclerosis short-chain fatty acids short-chain fatty acids high-fat diet-fed mice short-chain fatty acid long-chain fatty acids anti-inflammatory macrophage m2-type dietary-restricted pair-weighed control microbiome-host mammal line modulating microbiota–host–metabolic axes g-protein-coupled receptor ffar2 single-anastomosis duodenoileal bypass 15–30-cm-long pouch stemming placebo-controlled clinical trial adriana mika chapter google scholar article download pdf side duodeno-ileal diversion inflammation-induced pyroptosis pathway longer-term controlled studies diet-induced obese mice β3-adrenergic receptor activation gut-brain neural circuit metabolism search search djb-sa requires anastomosis amp-activated protein kinase branched amino acids gut/lung microbiome axis apolipoprotein e-deficiency mice mitochondrial oxidative phosphorylation long fatty acid microbiota-gut-brain connection sodium butyrate modulates increased fat oxidation fat mass regulation skeletal muscle tissue colonic cross-feeding patterns placebo-controlled trial gut-brain axis signalling plant cell-wall polysaccharides central nervous system jama netw open gut microbiota-dependent modulation van eijk hm increased β-cell mass bmc infect dis carbon chain length dietary fibre modulates diet-induced obesity glucose-dependent insulin secretion

Questions {❓}

Changes seen in gut bacteria content and distribution with obesity: causation or association?
From gut microbiota dysfunction to obesity: could short-chain fatty acids stop this dangerous course?
Knowing that BS leads to a reduction in food intake, the question is to what extent can restricted dietary intake contribute to these results?
Malnutrition as a complication of bariatric surgery - a clear and present danger?

Schema {🗺️}

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         Microbiota
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         general
         Metabolic Diseases
         Diabetes
         Cardiology
         Behavioral Therapy
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      name:Department of Environmental Analysis, University of Gdansk, Gdansk, Poland
      name:Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland

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