We are analyzing https://link.springer.com/article/10.1007/s13577-023-00996-2.

Title:
Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights | Human Cell
Description:
According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed that H. pylori infection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused on H. pylori’s role in GC development. According to our hypothesis, however, H. pylori infection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding how H. pylori possess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients with H. pylori infection with targeting autophagy and eradicating H. pylori infection.
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Keywords {🔍}

pubmed, google, scholar, cas, cancer, autophagy, central, cell, pylori, gastric, helicobacter, cells, role, infection, zhang, article, patients, tumor, biol, oncol, epithelial, wang, zalpoor, mol, death, chen, human, dormancy, akbari, progression, protein, kinase, lett, microbiol, induces, apoptosis, liu, research, induced, metastasis, targeting, gastroenterol, promotes, treatment, iran, recurrence, microrna, inhibitor, clin, pathway,

Topics {✒️}

ca-p60a/serca-dependent autophagosome-lysosome fusion ali yousefi rad host o-glycan-dependent manner h-pylori-induced gastric ulcer leptin-mediated epithelial-mesenchymal transition month download article/chapter bravo-san pedro jm v-atpase-dependent acidification mohsen nabi-afjadi exercise-induced cytokine release fibroblasts-derived vcam1 induced enhances imatinib-induced apoptosis parkin/pink1-dependent mitophagy inhibiting mir-125b-5p chronic myeloid leukemia pre-operative autophagy inhibition brca1-deficient breast cancer autophagy-based treatment strategy pi3k/akt-dependent pathway epithelial–mesenchymal transition promotion pi3k/mtor kinase inhibitor improving therapy responses ulk1/ampk inhibitor sbi-0206965 helicobacter pylori pathogenesis long-term covid-19 complications helicobacter pylori vaca helicobacter pylori caga helicobacter pylori caga helicobacter pylori eradication cancer models driven helicobacter pylori infection iii phosphoinositide 3-kinase related gastric cancer gastric cancer dormancy autophagy-dependent production anti-inflammatory phenotype suppressing autophagic flux blocking autophagic flux helicobacter pylori htra helicobacter pylori links privacy choices/manage cookies proapoptotic gene hid cox-2-mediated pathway paclitaxel-induced apoptosis human breast cancer tumor vessel normalization promotes temozolomide chemosensitivity full article pdf noorbakhsh varnosfaderani sm melika sadat haeri

Questions {❓}

Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells?

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         description:According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed that H. pylori infection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused on H. pylori’s role in GC development. According to our hypothesis, however, H. pylori infection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding how H. pylori possess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients with H. pylori infection with targeting autophagy and eradicating H. pylori infection.
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      description:According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed that H. pylori infection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused on H. pylori’s role in GC development. According to our hypothesis, however, H. pylori infection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding how H. pylori possess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients with H. pylori infection with targeting autophagy and eradicating H. pylori infection.
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