We are analyzing https://link.springer.com/article/10.1007/s13577-019-00237-5.

Title:
SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake | Human Cell
Description:
Bladder cancer (BC) is one of the most common tumors. Metabolic reprogramming is a feature of neoplasia and tumor growth. Understanding the metabolic alterations in bladder cancer may provide new directions for bladder cancer treatment. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic regulators. In pancreatic cancer, the loss of SIRT1 is accompanied by a decreased expression of proteins in the glycolysis pathway, such as GLUT1, and cancer cell proliferation. Thus, we hypothesize that SIRT1 may interact with GLUT1 to modulate the proliferation and glycolysis phenotype in bladder cancer. In the present study, the expression of SIRT1 and GLUT1 was upregulated in BC tissues and cell lines and positively correlated in tissue samples. SIRT1 overexpression or GLUT1 overexpression alone was sufficient to promote cell proliferation and glucose uptake in BC cells. EX527, a specific inhibitor of SIRT1, exerted an opposing effect on bladder cancer proliferation and glucose uptake. The effect of EX527 could be partially reversed by GLUT1 overexpression. More importantly, SIRT1 overexpression significantly promoted the transcriptional activity and expression of GLUT1, indicating that SIRT1 increases the transcription activity and expression of GLUT1, therefore, promoting the cell proliferation and glycolysis in BC cells. Our study first reported that SIRT1/GLUT1 axis promotes bladder cancer progression via regulation of glucose uptake.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

article, pubmed, cancer, google, scholar, sirt, cas, cell, bladder, glut, glucose, proliferation, expression, central, glycolysis, access, human, uptake, cells, biol, privacy, cookies, content, promotes, metabolic, biochem, hunan, information, publish, research, search, tumor, sirtuin, overexpression, effect, open, hospital, springer, analysis, data, log, journal, progression, regulation, published, chen, cao, yuanwei, growth, study,

Topics {✒️}

month download article/chapter stabilizes hypoxia-inducible factor-1alpha protein adp-ribosyltransferase activity bladder cancer progression full article pdf bladder cancer proliferation cancer cell proliferation bladder cancer treatment urothelial bladder cancer privacy choices/manage cookies regulates glut1 transcription mol cell biochem decreased glucose uptake independent prognostic factor promote cell proliferation glucose metabolism bmc syst biol yuanwei li nicotinamide alters proliferation article chen biomed res int mol cell biol renal cell carcinoma sirt1 increases european economic area sirt6 deficiency impairs hypoxanthine-xanthine oxidase chemical synthetic lethality sci transl med hunan normal university ethics declarations conflict mesenchymal stem cells bladder cancer bladder cancer check access instant access conditions privacy policy yeast sir2 gene foxo3a-mediated pathways pancreatic neoplastic lesions histone deacetylase inhibitors article log cells tissues organs electronic supplementary material accepting optional cookies improves insulin sensitivity author information authors additional information publisher human cell 32 glucose uptake

Schema {🗺️}

WebPage:
      mainEntity:
         headline:SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake
         description:Bladder cancer (BC) is one of the most common tumors. Metabolic reprogramming is a feature of neoplasia and tumor growth. Understanding the metabolic alterations in bladder cancer may provide new directions for bladder cancer treatment. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic regulators. In pancreatic cancer, the loss of SIRT1 is accompanied by a decreased expression of proteins in the glycolysis pathway, such as GLUT1, and cancer cell proliferation. Thus, we hypothesize that SIRT1 may interact with GLUT1 to modulate the proliferation and glycolysis phenotype in bladder cancer. In the present study, the expression of SIRT1 and GLUT1 was upregulated in BC tissues and cell lines and positively correlated in tissue samples. SIRT1 overexpression or GLUT1 overexpression alone was sufficient to promote cell proliferation and glucose uptake in BC cells. EX527, a specific inhibitor of SIRT1, exerted an opposing effect on bladder cancer proliferation and glucose uptake. The effect of EX527 could be partially reversed by GLUT1 overexpression. More importantly, SIRT1 overexpression significantly promoted the transcriptional activity and expression of GLUT1, indicating that SIRT1 increases the transcription activity and expression of GLUT1, therefore, promoting the cell proliferation and glycolysis in BC cells. Our study first reported that SIRT1/GLUT1 axis promotes bladder cancer progression via regulation of glucose uptake.
         datePublished:2019-03-13T00:00:00Z
         dateModified:2019-03-13T00:00:00Z
         pageStart:193
         pageEnd:201
         sameAs:https://doi.org/10.1007/s13577-019-00237-5
         keywords:
            Bladder cancer
            SIRT1
            GLUT1
            Glucose
            Cell proliferation
            Cell Biology
            Oncology
            Surgery
            Gynecology
            Reproductive Medicine
            Stem Cells
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig4_HTML.png
         isPartOf:
            name:Human Cell
            issn:
               1749-0774
            volumeNumber:32
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Japan
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jia Chen
               url:http://orcid.org/0000-0002-2461-6753
               affiliation:
                     name:The First Affiliated Hospital of Hunan Normal University
                     address:
                        name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lin Cao
               affiliation:
                     name:The First Affiliated Hospital of Hunan Normal University
                     address:
                        name:Department of Geriatrics, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhiqiu Li
               affiliation:
                     name:The First Affiliated Hospital of Hunan Normal University
                     address:
                        name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuanwei Li
               affiliation:
                     name:The First Affiliated Hospital of Hunan Normal University
                     address:
                        name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake
      description:Bladder cancer (BC) is one of the most common tumors. Metabolic reprogramming is a feature of neoplasia and tumor growth. Understanding the metabolic alterations in bladder cancer may provide new directions for bladder cancer treatment. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic regulators. In pancreatic cancer, the loss of SIRT1 is accompanied by a decreased expression of proteins in the glycolysis pathway, such as GLUT1, and cancer cell proliferation. Thus, we hypothesize that SIRT1 may interact with GLUT1 to modulate the proliferation and glycolysis phenotype in bladder cancer. In the present study, the expression of SIRT1 and GLUT1 was upregulated in BC tissues and cell lines and positively correlated in tissue samples. SIRT1 overexpression or GLUT1 overexpression alone was sufficient to promote cell proliferation and glucose uptake in BC cells. EX527, a specific inhibitor of SIRT1, exerted an opposing effect on bladder cancer proliferation and glucose uptake. The effect of EX527 could be partially reversed by GLUT1 overexpression. More importantly, SIRT1 overexpression significantly promoted the transcriptional activity and expression of GLUT1, indicating that SIRT1 increases the transcription activity and expression of GLUT1, therefore, promoting the cell proliferation and glycolysis in BC cells. Our study first reported that SIRT1/GLUT1 axis promotes bladder cancer progression via regulation of glucose uptake.
      datePublished:2019-03-13T00:00:00Z
      dateModified:2019-03-13T00:00:00Z
      pageStart:193
      pageEnd:201
      sameAs:https://doi.org/10.1007/s13577-019-00237-5
      keywords:
         Bladder cancer
         SIRT1
         GLUT1
         Glucose
         Cell proliferation
         Cell Biology
         Oncology
         Surgery
         Gynecology
         Reproductive Medicine
         Stem Cells
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13577-019-00237-5/MediaObjects/13577_2019_237_Fig4_HTML.png
      isPartOf:
         name:Human Cell
         issn:
            1749-0774
         volumeNumber:32
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Japan
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jia Chen
            url:http://orcid.org/0000-0002-2461-6753
            affiliation:
                  name:The First Affiliated Hospital of Hunan Normal University
                  address:
                     name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lin Cao
            affiliation:
                  name:The First Affiliated Hospital of Hunan Normal University
                  address:
                     name:Department of Geriatrics, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhiqiu Li
            affiliation:
                  name:The First Affiliated Hospital of Hunan Normal University
                  address:
                     name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuanwei Li
            affiliation:
                  name:The First Affiliated Hospital of Hunan Normal University
                  address:
                     name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Human Cell
      issn:
         1749-0774
      volumeNumber:32
Organization:
      name:Springer Japan
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The First Affiliated Hospital of Hunan Normal University
      address:
         name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
         type:PostalAddress
      name:The First Affiliated Hospital of Hunan Normal University
      address:
         name:Department of Geriatrics, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
         type:PostalAddress
      name:The First Affiliated Hospital of Hunan Normal University
      address:
         name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
         type:PostalAddress
      name:The First Affiliated Hospital of Hunan Normal University
      address:
         name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jia Chen
      url:http://orcid.org/0000-0002-2461-6753
      affiliation:
            name:The First Affiliated Hospital of Hunan Normal University
            address:
               name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Lin Cao
      affiliation:
            name:The First Affiliated Hospital of Hunan Normal University
            address:
               name:Department of Geriatrics, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Zhiqiu Li
      affiliation:
            name:The First Affiliated Hospital of Hunan Normal University
            address:
               name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Yuanwei Li
      affiliation:
            name:The First Affiliated Hospital of Hunan Normal University
            address:
               name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
      name:Department of Geriatrics, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
      name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
      name:Department of Urology Surgery, Hunan People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(106)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Isotope
Prism.js

CDN Services {📦}

Crossref

4.67s.

LINK . SPRINGER . COM {}