We are analyzing https://link.springer.com/article/10.1007/s13365-015-0383-6.

Title:
Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells | Journal of NeuroVirology
Description:
In the era of combined antiretroviral therapy (CART), many of the complications due to HIV-1 infection have diminished. One exception is HIV-associated neurocognitive disorder (HAND). HAND is a spectrum of disorders in cognitive function that ranges from asymptomatic disease to severe dementia (HAD). The milder form of HAND has actually remained the same or slightly increased in prevalence in the CART era. Even in individuals who have maintained undetectable HIV RNA loads, viral proteins such as Nef and Tat can continue to be expressed. In this report, we show that Nef protein and nef messenger RNA (mRNA) are packaged into exosomes that remain in circulation in patients with HAD. Plasma-derived Nef exosomes from patients with HAD have the ability to interact with the neuroblastoma cell line SH-SY5Y and deliver nef mRNA. The mRNA can induce expression of Nef in target cells and subsequently increase expression and secretion of beta-amyloid (Aβ) and Aβ peptides. Increase secretion of amyloid peptide could contribute to cognitive impairment seen in HAND.
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Keywords {🔍}

pubmed, article, google, scholar, hiv, cas, nef, central, dementia, aids, hivassociated, cells, cell, exosomes, disease, human, neurocognitive, individuals, khan, huang, powell, infection, immunodeficiency, neurol, mcarthur, brain, privacy, cookies, content, journal, secretion, bond, disorders, protein, patients, access, type, res, neurology, astrocyte, virus, publish, research, search, september, lang, era, hand, expression, betaamyloid,

Topics {✒️}

month download article/chapter sh-sy5y neural cells age-related macular degeneration nimhd/nih u54md007584 hiv-1 nef-mediated inhibition disease beta-amyloid peptides combined antiretroviral therapy increased beta-amyloid synthesis full article pdf hiv-infected patients treated churchill mj related subjects privacy choices/manage cookies plasma-derived nef exosomes updated research nosology human immunodeficiency virus human monocytic cells nef messenger rna simian immunodeficiency virus hiv-1 nef protein park iw autopsy brain tissues amyloid beta production nef exosomes isolated restricted virus replication promote virus replication woodcock sa exosome-mediated transfer cell signaling transduction cell signalling molecules intercellular nef transfer hiv-1 nef control astrocyte gene expression article journal european economic area subsequently increase expression plaque formation leading 11c-pib imaging robertson kr exosomal mirna profiles laser capture microdissection feather-stone rm rapid colorimetric determination common pathologic feature calmodulin-dependent manner pi3k/akt pathway utilizes nf-kb ap-1 transcription factors cerebrospinal fluid abnormalities du pasquier ra

Questions {❓}

Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease?

Schema {🗺️}

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         headline:Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells
         description:In the era of combined antiretroviral therapy (CART), many of the complications due to HIV-1 infection have diminished. One exception is HIV-associated neurocognitive disorder (HAND). HAND is a spectrum of disorders in cognitive function that ranges from asymptomatic disease to severe dementia (HAD). The milder form of HAND has actually remained the same or slightly increased in prevalence in the CART era. Even in individuals who have maintained undetectable HIV RNA loads, viral proteins such as Nef and Tat can continue to be expressed. In this report, we show that Nef protein and nef messenger RNA (mRNA) are packaged into exosomes that remain in circulation in patients with HAD. Plasma-derived Nef exosomes from patients with HAD have the ability to interact with the neuroblastoma cell line SH-SY5Y and deliver nef mRNA. The mRNA can induce expression of Nef in target cells and subsequently increase expression and secretion of beta-amyloid (Aβ) and Aβ peptides. Increase secretion of amyloid peptide could contribute to cognitive impairment seen in HAND.
         datePublished:2015-09-25T00:00:00Z
         dateModified:2015-09-25T00:00:00Z
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      description:In the era of combined antiretroviral therapy (CART), many of the complications due to HIV-1 infection have diminished. One exception is HIV-associated neurocognitive disorder (HAND). HAND is a spectrum of disorders in cognitive function that ranges from asymptomatic disease to severe dementia (HAD). The milder form of HAND has actually remained the same or slightly increased in prevalence in the CART era. Even in individuals who have maintained undetectable HIV RNA loads, viral proteins such as Nef and Tat can continue to be expressed. In this report, we show that Nef protein and nef messenger RNA (mRNA) are packaged into exosomes that remain in circulation in patients with HAD. Plasma-derived Nef exosomes from patients with HAD have the ability to interact with the neuroblastoma cell line SH-SY5Y and deliver nef mRNA. The mRNA can induce expression of Nef in target cells and subsequently increase expression and secretion of beta-amyloid (Aβ) and Aβ peptides. Increase secretion of amyloid peptide could contribute to cognitive impairment seen in HAND.
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         Nef
         Combination antiretroviral therapy
         HIV-associated neurocognitive disorders
         Amyloid
         Neurosciences
         Virology
         Infectious Diseases
         Immunology
         Neurology
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