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Title:
Neurological Complications of Ebola Virus Infection | Neurotherapeutics
Description:
Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.
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ebola, virus, disease, evd, pubmed, article, outbreak, survivors, google, scholar, patients, transmission, symptoms, infection, acute, neurologic, infect, viral, days, study, cases, persistence, med, cas, including, findings, outbreaks, onset, recent, dis, neurological, clinical, studies, mortality, treatment, guinea, care, health, manifestations, reported, africa, central, potential, fluids, patient, convalescent, case, west, zaire, marburg,
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int/reproductivehealth/topics/rtis/ebola-virus-semen/en/ int/ebola/current-situation/ebola-situation-report-17-february-2016 int/entity/emerging_diseases/ebola/who_his_sds_2014 magnetic resonance imaging /pressroom/home/getdigitalasset/12003 [abstract] bryan smith & avindra nath enzyme-linked immunosorbent assay world health organization altered mental status electrolyte disorders decreased short-term memory negative-strand rna virus detailed neurological evaluations eye movement abnormalities community-based initiatives rhesus macaque infected central nervous system west africa—clinical manifestations privacy choices/manage cookies full barrier ppe neurological symptoms necessitates public health organizations primarily central africa o'dempsey tj vaccine cad3-ebov ebov rna-positive semen actively taking care article billioux published detailed guidelines shown promise based severe neurologic manifestations poor health infrastructure green monkey disease neurological complications typical laboratory analyses overt neurologic manifestations cranial nerve abnormalities recent report details dilated fundus examinations reverse transcription-pcr ebola virus disease ebola virus genomes acute neurologic manifestations ebola hemorrhagic fever classical meningeal signs vesicular stomatitis virus niemann–picks disease niemann–pick disease ebola virus infection zaire ebola virus
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headline:Neurological Complications of Ebola Virus Infection
description:Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.
datePublished:2016-07-13T00:00:00Z
dateModified:2016-07-13T00:00:00Z
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Ebola
meningitis
encephalitis
microvascular disease
deafness
vertigo
insomnia
cognition
magnetic resonance imaging
Neurosciences
Neurology
Neurosurgery
Neurobiology
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headline:Neurological Complications of Ebola Virus Infection
description:Ebola virus disease is one of the deadliest pathogens known to man, with a mortality rate between 25–90% depending on the species and outbreak of Ebola. Typically, it presents with fever, headache, voluminous vomiting and diarrhea, and can progress to a hemorrhagic illness; neurologic symptoms, including meningoencephalitis, seizures, and coma, can also occur. Recently, an outbreak occurred in West Africa, affecting > 28,000 people, and killing > 11,000. Owing to the magnitude of this outbreak, and the large number (>17,000) of Ebola survivors, the medical and scientific communities are learning much more about the acute manifestations and sequelae of Ebola. A number of neurologic complications can occur after Ebola, such as seizures, memory loss, headaches, cranial nerve abnormalities, and tremor. Ebola may also persist in some immunologically privileged sites, including the central nervous system, and can rarely lead to relapse in disease. Owing to these findings, it is important that survivors are evaluated and monitored for neurologic symptoms. Much is unknown about this disease, and treatment remains largely supportive; however, with ongoing clinical and basic science, the mechanisms of how Ebola affects the central nervous system and how it persists after acute disease will hopefully become more clear, and better treatments and clinical practices for Ebola patients will be developed.
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dateModified:2016-07-13T00:00:00Z
pageStart:461
pageEnd:470
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keywords:
Ebola
meningitis
encephalitis
microvascular disease
deafness
vertigo
insomnia
cognition
magnetic resonance imaging
Neurosciences
Neurology
Neurosurgery
Neurobiology
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