We are analyzing https://link.springer.com/article/10.1007/s13277-013-1216-y.

Title:
RETRACTED ARTICLE: Prognostic and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis | Tumor Biology
Description:
Survivin has been widely reported to play a role in diagnosis and prognosis of bladder cancer patients. However, published data on this subject are heterogeneous. Here, we conducted a meta-analysis to obtain a complete evaluation of the association between survivin and recurrence-free survival (RFS), disease-specific survival (DSS), overall survival (OS), and odds ratio (OR) in bladder cancer patients. Published studies on this subject were selected for further assessment by online articles in PubMed, MEDLINE, EMBASE, and OVID databases. Pooled hazard ratios (HR) with 95 % confidence interval (95 % CI) were estimated. Funnel plots were used to evaluate the publication bias. As well, heterogeneity and sensitivity were analyzed. In this meta-analysis, we included 13 studies with the total number of 1,963 patients. Positive survivin expression in bladder cancer was associated with a poor RFS (HR, 1.831; 95 % CI, 1.344–2.49), DSS (HR, 1.721; 95 % CI, 1.477–2.004), or OS (HR, 1.753; 95 % CI, 1.092–2.816) in patients. In addition, a significant association between expression of survivin and age (OR, 0.641; 95 % CI, 0.416–0.987) as well as stage (OR, 0.37; 95 % CI, 0.190–0.750) was revealed. Heterogeneity was observed among the included studies with RFS (x 2 = 29.58, p = 0.009, I 2 = 52.7 %), OS (x 2 = 15.67, p = 0.008, I 2 = 68.1 %), and stage (x 2 = 11.97, p = 0.035, I 2 = 58.2 %). There was no publication bias according to Begg’s and Egger’s tests except for studies with gender. Furthermore, sensitivity analysis obtained the source of heterogeneity and confirmed opposite results of some studies. This study suggests that expression of survivin indicates poor prognosis in older patients and muscle invasive or advanced stage in bladder cancer. Survivin expression could be used in identifying a subgroup of patients with potential to benefit from a targeted therapy against survivin.
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Keywords {🔍}

article, cancer, google, scholar, survivin, pubmed, bladder, cas, patients, expression, metaanalysis, survival, carcinoma, prognostic, data, published, studies, shariat, cell, urothelial, privacy, cookies, content, significance, zhao, prognosis, publication, bias, access, review, ashfaq, information, publish, research, search, sun, stage, study, systematic, molecular, clin, karam, chen, res, lotan, oncol, karakiewicz, log, journal, tumor,

Topics {✒️}

month download article/chapter hong-shuo sun full article pdf urothelial bladder cancer related subjects privacy choices/manage cookies t1g3 bladder cancer bladder cancer presence sun lab staff bladder cancer recurrence advanced bladder cancer transitional cell carcinoma china scholarship council superficial urothelial carcinoma bladder cancer patients pt1 urothelial carcinoma retracted article clin cancer res human urinary bladder european economic area pooled hazard ratios confirmed opposite results folia histochem cytobiol incorporating summary time perform meta-analyses combined apoptosis biomarkers shariat sf meta-analysis detected article lv conditions privacy policy curr med chem med electron microsc upper urinary tract curr opin urol extracting summary statistics combined immunohistochemical markers von der maase interpreting medical data tumor biol clin transl oncol bladder cancer check access peer review process instant access accepting optional cookies karam ja sensitivity analysis obtained disease-specific survival survivin predict response recurrence-free survival

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         description:Survivin has been widely reported to play a role in diagnosis and prognosis of bladder cancer patients. However, published data on this subject are heterogeneous. Here, we conducted a meta-analysis to obtain a complete evaluation of the association between survivin and recurrence-free survival (RFS), disease-specific survival (DSS), overall survival (OS), and odds ratio (OR) in bladder cancer patients. Published studies on this subject were selected for further assessment by online articles in PubMed, MEDLINE, EMBASE, and OVID databases. Pooled hazard ratios (HR) with 95 % confidence interval (95 % CI) were estimated. Funnel plots were used to evaluate the publication bias. As well, heterogeneity and sensitivity were analyzed. In this meta-analysis, we included 13 studies with the total number of 1,963 patients. Positive survivin expression in bladder cancer was associated with a poor RFS (HR, 1.831; 95 % CI, 1.344–2.49), DSS (HR, 1.721; 95 % CI, 1.477–2.004), or OS (HR, 1.753; 95 % CI, 1.092–2.816) in patients. In addition, a significant association between expression of survivin and age (OR, 0.641; 95 % CI, 0.416–0.987) as well as stage (OR, 0.37; 95 % CI, 0.190–0.750) was revealed. Heterogeneity was observed among the included studies with RFS (x 2 = 29.58, p = 0.009, I 2 = 52.7 %), OS (x 2 = 15.67, p = 0.008, I 2 = 68.1 %), and stage (x 2 = 11.97, p = 0.035, I 2 = 58.2 %). There was no publication bias according to Begg’s and Egger’s tests except for studies with gender. Furthermore, sensitivity analysis obtained the source of heterogeneity and confirmed opposite results of some studies. This study suggests that expression of survivin indicates poor prognosis in older patients and muscle invasive or advanced stage in bladder cancer. Survivin expression could be used in identifying a subgroup of patients with potential to benefit from a targeted therapy against survivin.
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