We are analyzing https://link.springer.com/article/10.1007/s13277-013-0842-8.

Title:
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets | Tumor Biology
Description:
Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs). This is a family of proteolytic enzymes that are involved in many phases of cancer progression, including angiogenesis, invasiveness, and metastasis. It has therefore been expected that MMPs could serve as both diagnostic and prognostic markers in cancer patients, but despite a huge number of studies, it has been difficult to establish MMPs as cancer biomarkers. In the present paper, we assess some of the challenges associated with MMP research as well as putative reasons for the conflicting data on the value of these enzymes as diagnostic and prognostic markers in cancer patients. We also review the prognostic value of a number of MMPs in patients with lung, colorectal, breast, and prostate cancers. The review also discusses MMPs as potential target molecules for therapeutic agents and new strategies for development of such drugs.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

cancer, google, scholar, pubmed, article, cas, matrix, mmp, metalloproteinase, metalloproteinases, lung, cell, expression, patients, prognostic, breast, res, colorectal, inhibitors, nonsmall, int, clin, tissue, tumor, biol, survival, serum, prostate, human, mmps, carcinoma, oncol, zhang, analysis, markers, metastasis, nat, marker, prognosis, gonzalez, levels, matrisian, role, cells, inhibitor, significance, diagnostic, hadlerolsen, biomarkers, progression,

Topics {✒️}

reversion-inducing cysteine-rich protein month download article/chapter elin hadler-olsen article hadler-olsen triple-helical collagen cleavage stetler-stevenson wg tumor-derived matrix metalloproteinase-13 oral cancer biomarkers c-fos/activator protein-1 small-cell lung cancer metalloproteinase-independent biological activities potential molecular markers full article pdf gelatinase a-deficient mice matrix metalloproteinase-9/neutrophil gelatinase type iv collagenase promotes tumor invasion active matrix metalloproteinase-2 privacy choices/manage cookies cancer biomarkers author information authors breast tumor growth urinary bladder cancer butler gs squamous cell carcinoma stromal matrix metalloproteinase-12 serum mmp-2/timp-2—complex fitc-labeled collagen tumor-derived proteinases serum matrix metalloproteinase-9 serum matrix metalloproteinase-2 serum matrix-metalloproteinase-1 stage iiia pn2 breast cancer—potential role related subjects renal cell carcinoma nat cell biol matrix metalloproteinase-9 triggers matrix metalloproteinase proteomics intratumor stromal fibroblasts norwegian cancer society renal cell carcinomas matrix metalloproteinase-1 levels matrix metalloproteinase activity fas-mediated apoptosis advanced lung adenocarcinoma poor prognostic factor decreased tumor formation plasma matrix metalloproteinase-7 human breast cancer

Questions {❓}

Matrix metalloproteinases and angiogenic factors: predictors of survival after radical prostatectomy for clinically organ-confined prostate cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
         description:Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs). This is a family of proteolytic enzymes that are involved in many phases of cancer progression, including angiogenesis, invasiveness, and metastasis. It has therefore been expected that MMPs could serve as both diagnostic and prognostic markers in cancer patients, but despite a huge number of studies, it has been difficult to establish MMPs as cancer biomarkers. In the present paper, we assess some of the challenges associated with MMP research as well as putative reasons for the conflicting data on the value of these enzymes as diagnostic and prognostic markers in cancer patients. We also review the prognostic value of a number of MMPs in patients with lung, colorectal, breast, and prostate cancers. The review also discusses MMPs as potential target molecules for therapeutic agents and new strategies for development of such drugs.
         datePublished:2013-05-17T00:00:00Z
         dateModified:2013-05-17T00:00:00Z
         pageStart:2041
         pageEnd:2051
         sameAs:https://doi.org/10.1007/s13277-013-0842-8
         keywords:
            Matrix metalloproteinase
            Cancer
            Biomarkers
            Drug design
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-0842-8/MediaObjects/13277_2013_842_Fig1_HTML.gif
         isPartOf:
            name:Tumor Biology
            issn:
               1423-0380
               1010-4283
            volumeNumber:34
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Elin Hadler-Olsen
               affiliation:
                     name:University of Tromsø
                     address:
                        name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jan-Olof Winberg
               affiliation:
                     name:University of Tromsø
                     address:
                        name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars Uhlin-Hansen
               affiliation:
                     name:University of Tromsø
                     address:
                        name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                        type:PostalAddress
                     type:Organization
                     name:University Hospital of North Norway
                     address:
                        name:Department of Pathology, University Hospital of North Norway, Tromsø, Norway
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
      description:Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most cancers, there are increased levels of one or several members of the matrix metalloproteinases (MMPs). This is a family of proteolytic enzymes that are involved in many phases of cancer progression, including angiogenesis, invasiveness, and metastasis. It has therefore been expected that MMPs could serve as both diagnostic and prognostic markers in cancer patients, but despite a huge number of studies, it has been difficult to establish MMPs as cancer biomarkers. In the present paper, we assess some of the challenges associated with MMP research as well as putative reasons for the conflicting data on the value of these enzymes as diagnostic and prognostic markers in cancer patients. We also review the prognostic value of a number of MMPs in patients with lung, colorectal, breast, and prostate cancers. The review also discusses MMPs as potential target molecules for therapeutic agents and new strategies for development of such drugs.
      datePublished:2013-05-17T00:00:00Z
      dateModified:2013-05-17T00:00:00Z
      pageStart:2041
      pageEnd:2051
      sameAs:https://doi.org/10.1007/s13277-013-0842-8
      keywords:
         Matrix metalloproteinase
         Cancer
         Biomarkers
         Drug design
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-013-0842-8/MediaObjects/13277_2013_842_Fig1_HTML.gif
      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:34
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Elin Hadler-Olsen
            affiliation:
                  name:University of Tromsø
                  address:
                     name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jan-Olof Winberg
            affiliation:
                  name:University of Tromsø
                  address:
                     name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars Uhlin-Hansen
            affiliation:
                  name:University of Tromsø
                  address:
                     name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
                     type:PostalAddress
                  type:Organization
                  name:University Hospital of North Norway
                  address:
                     name:Department of Pathology, University Hospital of North Norway, Tromsø, Norway
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tumor Biology
      issn:
         1423-0380
         1010-4283
      volumeNumber:34
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Tromsø
      address:
         name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
         type:PostalAddress
      name:University of Tromsø
      address:
         name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
         type:PostalAddress
      name:University of Tromsø
      address:
         name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
         type:PostalAddress
      name:University Hospital of North Norway
      address:
         name:Department of Pathology, University Hospital of North Norway, Tromsø, Norway
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Elin Hadler-Olsen
      affiliation:
            name:University of Tromsø
            address:
               name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jan-Olof Winberg
      affiliation:
            name:University of Tromsø
            address:
               name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
               type:PostalAddress
            type:Organization
      name:Lars Uhlin-Hansen
      affiliation:
            name:University of Tromsø
            address:
               name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
               type:PostalAddress
            type:Organization
            name:University Hospital of North Norway
            address:
               name:Department of Pathology, University Hospital of North Norway, Tromsø, Norway
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
      name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
      name:Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
      name:Department of Pathology, University Hospital of North Norway, Tromsø, Norway
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(396)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.55s.

LINK . SPRINGER . COM {}