We are analyzing https://link.springer.com/article/10.1007/s13277-012-0408-1.

Title:
TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk | Tumor Biology
Description:
Although the implication of genetic factors in cervical cancer development remains to be elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine genes may be involved in the etiology of cervical carcinoma. Tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) are two multifunctional cytokines implicated in inflammation, immunity, and cellular organization, and were proposed to play important roles in cancer biology. In order to determine whether IL-10 -1082 (G/A) and TNF-α -238 (G/A) and -308 (G/A) polymorphisms are associated with susceptibility to cervical cancer, a case–control study of 122 cancer patients and 176 healthy controls was conducted. Cervical samples were genotyped for both TNF-α polymorphisms by PCR-RFLP assay. SNP-1082 from IL-10 gene was genotyped using pyrosequencing technology. The association between cervical cancer risk and the studied SNPs was evaluated by logistic regression. Under univariate analysis, none of these polymorphisms appeared associated with susceptibility of cervical cancer development or HPV infection. However, individuals carrying heterozygous genotype for TNF-α -238 polymorphism seem to be at lower risk for cervical cancer development, with borderline significance (OR = 0.42, P = 0.069), as well as those carrying heterozygous genotypes for IL-10 and TNF-α -238 (OR = 0.40, P = 0.08). In conclusion, these results suggest a potential effect of TNF-α -238 G/A in the reduction of cervical cancer risk in Argentine women, but not TNF-α -308 or IL-10. Larger studies are needed to fully understand the genetic predisposition for the development of cervical cancer.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, pubmed, google, scholar, cancer, cervical, cas, polymorphisms, tumor, necrosis, promoter, polymorphism, human, tnfα, risk, factor, susceptibility, infection, alpha, interleukin, gene, papillomavirus, central, factoralpha, genetic, women, clin, hpv, int, privacy, cookies, content, research, oncol, tnfalpha, gynecol, analysis, publish, search, barbisan, development, cytokine, genes, patients, association, access, med, natl, eur, disease,

Topics {✒️}

tumour necrosis factor-alpha tumor necrosis factor-alpha month download article/chapter tumor necrosis factor vitro tnf-alpha production tnf-alpha promoter polymorphisms early-onset psoriasis vulgaris tnf-α promoter snps full article pdf privacy choices/manage cookies human leukocyte antigen stanczuk ga tnf-α -238 polymorphism population-based study gene polymorphism coding human papillomavirus types genital human papillomavirus human nucleated cells interleukin-10 gene promoter promoter region polymorphisms il-10 promoter polymorphisms tnf-α polymorphisms carrying heterozygous genotypes il-27 genetic polymorphisms northern polish population southern chinese patients italian caucasian population human papillomavirus infection pcr-rflp assay interleukin-10–1082 gene polymorphism european economic area natl cancer inst interleukin-10 promoter polymorphisms invasive cervical carcinomas increased il-10 production multifunctional cytokines implicated play important roles ho gy insulin-deficient phenotype chronic active hepatitis increased blood levels nucleic acids res degenerate general primers calhoun es systemic lupus erythematosus article barbisan single nucleotide polymorphisms nat rev cancer conditions privacy policy cervical cancer development

Questions {❓}

Familial risks in cervical cancer: is there a hereditary component?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
         description:Although the implication of genetic factors in cervical cancer development remains to be elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine genes may be involved in the etiology of cervical carcinoma. Tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) are two multifunctional cytokines implicated in inflammation, immunity, and cellular organization, and were proposed to play important roles in cancer biology. In order to determine whether IL-10 -1082 (G/A) and TNF-α -238 (G/A) and -308 (G/A) polymorphisms are associated with susceptibility to cervical cancer, a case–control study of 122 cancer patients and 176 healthy controls was conducted. Cervical samples were genotyped for both TNF-α polymorphisms by PCR-RFLP assay. SNP-1082 from IL-10 gene was genotyped using pyrosequencing technology. The association between cervical cancer risk and the studied SNPs was evaluated by logistic regression. Under univariate analysis, none of these polymorphisms appeared associated with susceptibility of cervical cancer development or HPV infection. However, individuals carrying heterozygous genotype for TNF-α -238 polymorphism seem to be at lower risk for cervical cancer development, with borderline significance (OR = 0.42, P = 0.069), as well as those carrying heterozygous genotypes for IL-10 and TNF-α -238 (OR = 0.40, P = 0.08). In conclusion, these results suggest a potential effect of TNF-α -238 G/A in the reduction of cervical cancer risk in Argentine women, but not TNF-α -308 or IL-10. Larger studies are needed to fully understand the genetic predisposition for the development of cervical cancer.
         datePublished:2012-05-17T00:00:00Z
         dateModified:2012-05-17T00:00:00Z
         pageStart:1549
         pageEnd:1556
         sameAs:https://doi.org/10.1007/s13277-012-0408-1
         keywords:
            Cervical cancer
            IL-10
            TNF-α
            Polymorphisms
            HPV
            Cancer Research
         image:
         isPartOf:
            name:Tumor Biology
            issn:
               1423-0380
               1010-4283
            volumeNumber:33
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Gisela Barbisan
               affiliation:
                     name:Universidad Nacional de La Plata
                     address:
                        name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Luis Orlando Pérez
               affiliation:
                     name:Universidad Nacional de La Plata
                     address:
                        name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anahí Contreras
               affiliation:
                     name:Universidad Nacional de La Plata
                     address:
                        name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Daniel Golijow
               affiliation:
                     name:Universidad Nacional de La Plata
                     address:
                        name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
      description:Although the implication of genetic factors in cervical cancer development remains to be elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine genes may be involved in the etiology of cervical carcinoma. Tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) are two multifunctional cytokines implicated in inflammation, immunity, and cellular organization, and were proposed to play important roles in cancer biology. In order to determine whether IL-10 -1082 (G/A) and TNF-α -238 (G/A) and -308 (G/A) polymorphisms are associated with susceptibility to cervical cancer, a case–control study of 122 cancer patients and 176 healthy controls was conducted. Cervical samples were genotyped for both TNF-α polymorphisms by PCR-RFLP assay. SNP-1082 from IL-10 gene was genotyped using pyrosequencing technology. The association between cervical cancer risk and the studied SNPs was evaluated by logistic regression. Under univariate analysis, none of these polymorphisms appeared associated with susceptibility of cervical cancer development or HPV infection. However, individuals carrying heterozygous genotype for TNF-α -238 polymorphism seem to be at lower risk for cervical cancer development, with borderline significance (OR = 0.42, P = 0.069), as well as those carrying heterozygous genotypes for IL-10 and TNF-α -238 (OR = 0.40, P = 0.08). In conclusion, these results suggest a potential effect of TNF-α -238 G/A in the reduction of cervical cancer risk in Argentine women, but not TNF-α -308 or IL-10. Larger studies are needed to fully understand the genetic predisposition for the development of cervical cancer.
      datePublished:2012-05-17T00:00:00Z
      dateModified:2012-05-17T00:00:00Z
      pageStart:1549
      pageEnd:1556
      sameAs:https://doi.org/10.1007/s13277-012-0408-1
      keywords:
         Cervical cancer
         IL-10
         TNF-α
         Polymorphisms
         HPV
         Cancer Research
      image:
      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:33
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Gisela Barbisan
            affiliation:
                  name:Universidad Nacional de La Plata
                  address:
                     name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Luis Orlando Pérez
            affiliation:
                  name:Universidad Nacional de La Plata
                  address:
                     name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anahí Contreras
            affiliation:
                  name:Universidad Nacional de La Plata
                  address:
                     name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Daniel Golijow
            affiliation:
                  name:Universidad Nacional de La Plata
                  address:
                     name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tumor Biology
      issn:
         1423-0380
         1010-4283
      volumeNumber:33
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universidad Nacional de La Plata
      address:
         name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
         type:PostalAddress
      name:Universidad Nacional de La Plata
      address:
         name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
         type:PostalAddress
      name:Universidad Nacional de La Plata
      address:
         name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
         type:PostalAddress
      name:Universidad Nacional de La Plata
      address:
         name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Gisela Barbisan
      affiliation:
            name:Universidad Nacional de La Plata
            address:
               name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Luis Orlando Pérez
      affiliation:
            name:Universidad Nacional de La Plata
            address:
               name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Anahí Contreras
      affiliation:
            name:Universidad Nacional de La Plata
            address:
               name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Carlos Daniel Golijow
      affiliation:
            name:Universidad Nacional de La Plata
            address:
               name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
PostalAddress:
      name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
      name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
      name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
      name:IGEVET (Instituto de Genética Veterinaria “Ingeniero Fernando Noel Dulout”), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Buenos Aires, Argentina
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(174)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.07s.

LINK . SPRINGER . COM {}