We are analyzing https://link.springer.com/article/10.1007/s13238-017-0431-5.

Title:
RIG-I: a multifunctional protein beyond a pattern recognition receptor | Protein & Cell
Description:
It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. However, recent studies showed that RIG-I participates in other various cellular activities by sensing endogenous RNAs under different circumstances. For example, RIG-I facilitates the therapy resistance and expansion of breast cancer cells and promotes T cell-independent B cell activation through interferon signaling activation by recognizing non-coding RNAs and endogenous retroviruses in certain situations. While in hepatocellular carcinoma and acute myeloid leukemia, RIG-I acts as a tumor suppressor through either augmenting STAT1 activation by competitively binding STAT1 against its negative regulator SHP1 or inhibiting AKT-mTOR signaling pathway by directly interacting with Src respectively. These new findings suggest that RIG-I plays more diverse roles in various cellular life activities, such as cell proliferation and differentiation, than previously known. Taken together, the function of RIG-I exceeds far beyond that of a pattern recognition receptor.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

rigi, pubmed, article, google, scholar, cas, rna, rnas, cells, activation, antiviral, cell, central, signaling, cancer, viral, protein, immunity, virus, recognition, endogenous, innate, pathway, zhang, chen, functions, binding, lys, cellular, immune, ifn, liu, receptor, stat, expression, responses, polyubiquitination, wang, essential, shao, proliferation, human, response, yoneyama, jiang, function, pattern, access, gene, leukemia,

Topics {✒️}

activated tgf-β/akt/smad2 signaling rig-i-dependent anticancer immunity rig-i-dependent antiviral responses pi3k-dependent nf-kappab activation rig-i-mediated antiviral responses protein kinase c-α/β jian-zhong shao declare rig-i-mediated antiviral activity trans-retinoic acid-induced differentiation rig-i-mediated antiviral signaling dexd/h-box helicases rig rig-i-mediated innate immunity rig-i-mediated antiviral response riplet-mediated k63-linked polyubiquitination recombinant interferon beta-1a article download pdf rig-i-mavs signaling pathway cyclic gmp-amp synthase sh2-ta binding domain activate pi3k/akt signaling unanchored k63-ubiquitin chains amino-acid-substitution mutant mitochondrion-targeting chaperone 14-3-3ε jian-zhong shao n1-2′o-methylteansferase induces rig-i-mediated biology cancer cell-selective apoptosis cell-intrinsic immune response interferon-alpha therapeutic response protein phosphatase 1α/γ restrain leukemic stemness li-xin xiang e3 ligase fbxw7 ir-induced cytotoxic responses cell type-specific involvement ifn-/ra-induced differentiation pattern recognition receptor atp-hydrolysis-deficient rig shp2/c-cbl complex including post-transcriptional modifications 50-ε stem-loop region related subjects pancreatic ductal adenocarcinoma tgf-β gene de oliveira mc autophagy signaling pathways interferon stimulatory genes trans-retinoic acid animal subjects performed privacy choices/manage cookies

Schema {🗺️}

WebPage:
      mainEntity:
         headline:RIG-I: a multifunctional protein beyond a pattern recognition receptor
         description:It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. However, recent studies showed that RIG-I participates in other various cellular activities by sensing endogenous RNAs under different circumstances. For example, RIG-I facilitates the therapy resistance and expansion of breast cancer cells and promotes T cell-independent B cell activation through interferon signaling activation by recognizing non-coding RNAs and endogenous retroviruses in certain situations. While in hepatocellular carcinoma and acute myeloid leukemia, RIG-I acts as a tumor suppressor through either augmenting STAT1 activation by competitively binding STAT1 against its negative regulator SHP1 or inhibiting AKT-mTOR signaling pathway by directly interacting with Src respectively. These new findings suggest that RIG-I plays more diverse roles in various cellular life activities, such as cell proliferation and differentiation, than previously known. Taken together, the function of RIG-I exceeds far beyond that of a pattern recognition receptor.
         datePublished:2017-06-08T00:00:00Z
         dateModified:2017-06-08T00:00:00Z
         pageStart:246
         pageEnd:253
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s13238-017-0431-5
         keywords:
            RIG-I
            viral RNA
            endogenous RNA
            immunity
            cancer
            Biochemistry
            general
            Protein Science
            Cell Biology
            Stem Cells
            Human Genetics
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-017-0431-5/MediaObjects/13238_2017_431_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-017-0431-5/MediaObjects/13238_2017_431_Fig2_HTML.gif
         isPartOf:
            name:Protein & Cell
            issn:
               1674-8018
               1674-800X
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Higher Education Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xiao-xiao Xu
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Han Wan
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li Nie
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tong Shao
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li-xin Xiang
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jian-zhong Shao
               affiliation:
                     name:Zhejiang University
                     address:
                        name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Qingdao National Laboratory for Marine Science and Technology
                     address:
                        name:Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:RIG-I: a multifunctional protein beyond a pattern recognition receptor
      description:It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. However, recent studies showed that RIG-I participates in other various cellular activities by sensing endogenous RNAs under different circumstances. For example, RIG-I facilitates the therapy resistance and expansion of breast cancer cells and promotes T cell-independent B cell activation through interferon signaling activation by recognizing non-coding RNAs and endogenous retroviruses in certain situations. While in hepatocellular carcinoma and acute myeloid leukemia, RIG-I acts as a tumor suppressor through either augmenting STAT1 activation by competitively binding STAT1 against its negative regulator SHP1 or inhibiting AKT-mTOR signaling pathway by directly interacting with Src respectively. These new findings suggest that RIG-I plays more diverse roles in various cellular life activities, such as cell proliferation and differentiation, than previously known. Taken together, the function of RIG-I exceeds far beyond that of a pattern recognition receptor.
      datePublished:2017-06-08T00:00:00Z
      dateModified:2017-06-08T00:00:00Z
      pageStart:246
      pageEnd:253
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s13238-017-0431-5
      keywords:
         RIG-I
         viral RNA
         endogenous RNA
         immunity
         cancer
         Biochemistry
         general
         Protein Science
         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-017-0431-5/MediaObjects/13238_2017_431_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-017-0431-5/MediaObjects/13238_2017_431_Fig2_HTML.gif
      isPartOf:
         name:Protein & Cell
         issn:
            1674-8018
            1674-800X
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Higher Education Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xiao-xiao Xu
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Han Wan
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li Nie
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tong Shao
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li-xin Xiang
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jian-zhong Shao
            affiliation:
                  name:Zhejiang University
                  address:
                     name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Qingdao National Laboratory for Marine Science and Technology
                  address:
                     name:Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Protein & Cell
      issn:
         1674-8018
         1674-800X
      volumeNumber:9
Organization:
      name:Higher Education Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Qingdao National Laboratory for Marine Science and Technology
      address:
         name:Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xiao-xiao Xu
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Han Wan
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Li Nie
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Tong Shao
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Li-xin Xiang
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jian-zhong Shao
      affiliation:
            name:Zhejiang University
            address:
               name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Qingdao National Laboratory for Marine Science and Technology
            address:
               name:Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China

External Links {🔗}(221)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Particles.js
Prism.js

CDN Services {📦}

Crossref

4.31s.

LINK . SPRINGER . COM {}