We are analyzing https://link.springer.com/article/10.1007/s13238-014-0082-8.

Title:
Regulation of the pentose phosphate pathway in cancer | Protein & Cell
Description:
Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.
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Keywords {🔍}

ppp, article, cell, cells, google, scholar, cancer, gpd, glucose, glycolysis, nadph, metabolism, oxidative, activity, pathway, jiang, kinase, flux, growth, proliferation, metabolic, regulation, tumor, cellular, biosynthesis, role, glycolytic, protein, human, dehydrogenase, activation, stress, production, pathways, expression, inhibition, glutamine, glucosephosphate, warburg, mutations, idh, phosphate, energy, survival, enzyme, biol, intermediates, signaling, cancers, increase,

Topics {✒️}

diffuse large-b-cell lymphoma amp-activated protein kinase high-rate pentose-phosphate pathways ataxia-telangiectasia mutated kinase serine-threonine kinase akt carcinogen-induced murine model full size image p53-dependent metabolic checkpoint protein-protein interactions tumor-suppressive metabolic state targeting pi3k signalling human glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase deficiency phosphoinositide 3-kinase/akt pathway anti-cancer drug development nadp+-dependent ‘malic’ enzyme carbon sugar r5p schwartzenberg-bar-yoseph cyclic adenosine monophosphate glucose-6-phosphate dehydrogenase activity cellular amp/atp ratio targeting cancer metabolism—aiming 5’-amp-activated kinase green arrows represent k-rasg12d inactivation leads article download pdf pi3k/akt signaling pathway requires phosphatidylinositol 3-kinase cellular nadp+/nadph ratio tap73-mediated cell proliferation privacy choices/manage cookies including protein expression pentose phosphate pathway atm/hsp27 signaling pathways related subjects isocitrate–α-kg reaction oxidative stress-mediated ppp glucose-6-phosphate dehydrogenase cell-type dependent severe g6pd deficiency hexose monophosphate shunt p53 target gene phosphate-activated glutaminase transcription-dependent manner phosphoinositide 3-kinase pathway mian wu declare anti-cancer therapy full access reactive oxygen species pka-mediated phosphorylation

Schema {🗺️}

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         headline:Regulation of the pentose phosphate pathway in cancer
         description:Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.
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      headline:Regulation of the pentose phosphate pathway in cancer
      description:Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.
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         pentose phosphate pathway (PPP)
         G6PD
         NADPH
         glucose metabolism
         cancer
         cell proliferation
         Biochemistry
         general
         Protein Science
         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
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               type:PostalAddress
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