We are analyzing https://link.springer.com/article/10.1007/s13238-013-3092-z.

Title:
Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development | Protein & Cell
Description:
Tumor-associated macrophages (TAMs) mostly exhibit M2-like (alternatively activated) properties and play positive roles in angiogenesis and tumorigenesis. Vascular endothelial growth factor (VEGF) is a key angiogenic factor. During tumor development, TAMs secrete VEGF and other factors to promote angiogenesis; thus, anti-treatment against TAMs and VEGF can repress cancer development, which has been demonstrated in clinical trials and on an experimental level. In the present work, we show that miR-150 is an oncomir because of its promotional effect on VEGF. MiR-150 targets TAMs to up-regulate their secretion of VEGF in vitro. With the utilization of cell-derived vesicles, named microvesicles (MVs), we transferred antisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis. Therefore, we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel, natural, microvesicle-based method for the transfer of nucleic acids.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Careers

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

article, google, scholar, cancer, angiogenesis, cell, tumor, vegf, factor, zhang, growth, macrophages, nat, tumorigenesis, tumorassociated, role, research, endothelial, breast, cells, privacy, cookies, development, liu, lewis, progression, rev, ferrara, content, publish, search, protein, neutralization, download, yin, tams, vascular, suppresses, tumour, res, nature, pollard, data, information, journal, promotes, zhao, yuan, chenyu, jing,

Topics {✒️}

mtor/hif-1α/vegf signaling axis tumor-suppressor gene inhibitor microrna-140-5p inhibits invasion promote oxygen-dependent degradation hypoxia-inducible factor 1alpha microvesicle-based method hypoxia inducible factor cell-derived vesicles protein cell 4 privacy choices/manage cookies tumor metabolism growth related subjects state key laboratory repress cancer development tumor microenvironment cancer research anti-oncomir suppression search search tumour angiogenesis key angiogenic factor mir-150 targets tams main content log inducing macrophage polarization tumour progression myeloma-induced angiogenesis european economic area play positive roles conditions privacy policy targeted exosomes chen-yu zhang accepting optional cookies experimental liver metastasis yujing zhang article liu tams secrete vegf breast cancer exosome-mediated transfer cancer cell 21 cancer cell 19 journal finder publish tumor development anti-treatment authors correspondence jing li promote angiogenesis neutralizing mir-150 secreted micrornas sirna delivery tumor progression article cite

Questions {❓}

Angiogenesis: an organizing principle for drug discovery?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development
         description:Tumor-associated macrophages (TAMs) mostly exhibit M2-like (alternatively activated) properties and play positive roles in angiogenesis and tumorigenesis. Vascular endothelial growth factor (VEGF) is a key angiogenic factor. During tumor development, TAMs secrete VEGF and other factors to promote angiogenesis; thus, anti-treatment against TAMs and VEGF can repress cancer development, which has been demonstrated in clinical trials and on an experimental level. In the present work, we show that miR-150 is an oncomir because of its promotional effect on VEGF. MiR-150 targets TAMs to up-regulate their secretion of VEGF in vitro. With the utilization of cell-derived vesicles, named microvesicles (MVs), we transferred antisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis. Therefore, we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel, natural, microvesicle-based method for the transfer of nucleic acids.
         datePublished:2013-11-07T00:00:00Z
         dateModified:2013-11-07T00:00:00Z
         pageStart:932
         pageEnd:941
         sameAs:https://doi.org/10.1007/s13238-013-3092-z
         keywords:
            microvesicle
            miR-150
            tumorigenesis
            VEGF
            neutralization
            attenuation
            Biochemistry
            general
            Protein Science
            Cell Biology
            Stem Cells
            Human Genetics
            Developmental Biology
         image:
         isPartOf:
            name:Protein & Cell
            issn:
               1674-8018
               1674-800X
            volumeNumber:4
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Higher Education Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yuchen Liu
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Luming Zhao
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dameng Li
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuan Yin
               affiliation:
                     name:Fourth Affi liated Hospital of Suzhou University
                     address:
                        name:Oncology Institute, Fourth Affi liated Hospital of Suzhou University, Wuxi, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen-Yu Zhang
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jing Li
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yujing Zhang
               affiliation:
                     name:Nanjing University
                     address:
                        name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development
      description:Tumor-associated macrophages (TAMs) mostly exhibit M2-like (alternatively activated) properties and play positive roles in angiogenesis and tumorigenesis. Vascular endothelial growth factor (VEGF) is a key angiogenic factor. During tumor development, TAMs secrete VEGF and other factors to promote angiogenesis; thus, anti-treatment against TAMs and VEGF can repress cancer development, which has been demonstrated in clinical trials and on an experimental level. In the present work, we show that miR-150 is an oncomir because of its promotional effect on VEGF. MiR-150 targets TAMs to up-regulate their secretion of VEGF in vitro. With the utilization of cell-derived vesicles, named microvesicles (MVs), we transferred antisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis. Therefore, we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel, natural, microvesicle-based method for the transfer of nucleic acids.
      datePublished:2013-11-07T00:00:00Z
      dateModified:2013-11-07T00:00:00Z
      pageStart:932
      pageEnd:941
      sameAs:https://doi.org/10.1007/s13238-013-3092-z
      keywords:
         microvesicle
         miR-150
         tumorigenesis
         VEGF
         neutralization
         attenuation
         Biochemistry
         general
         Protein Science
         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
      image:
      isPartOf:
         name:Protein & Cell
         issn:
            1674-8018
            1674-800X
         volumeNumber:4
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Higher Education Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yuchen Liu
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Luming Zhao
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dameng Li
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuan Yin
            affiliation:
                  name:Fourth Affi liated Hospital of Suzhou University
                  address:
                     name:Oncology Institute, Fourth Affi liated Hospital of Suzhou University, Wuxi, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen-Yu Zhang
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jing Li
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yujing Zhang
            affiliation:
                  name:Nanjing University
                  address:
                     name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Protein & Cell
      issn:
         1674-8018
         1674-800X
      volumeNumber:4
Organization:
      name:Higher Education Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
      name:Fourth Affi liated Hospital of Suzhou University
      address:
         name:Oncology Institute, Fourth Affi liated Hospital of Suzhou University, Wuxi, China
         type:PostalAddress
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
      name:Nanjing University
      address:
         name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yuchen Liu
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Luming Zhao
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Dameng Li
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Yuan Yin
      affiliation:
            name:Fourth Affi liated Hospital of Suzhou University
            address:
               name:Oncology Institute, Fourth Affi liated Hospital of Suzhou University, Wuxi, China
               type:PostalAddress
            type:Organization
      name:Chen-Yu Zhang
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jing Li
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yujing Zhang
      affiliation:
            name:Nanjing University
            address:
               name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
      name:Oncology Institute, Fourth Affi liated Hospital of Suzhou University, Wuxi, China
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
      name:Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China

External Links {🔗}(104)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Particles.js
Prism.js

CDN Services {📦}

Crossref

6.09s.

LINK . SPRINGER . COM {}