We are analyzing https://link.springer.com/article/10.1007/s13238-013-3014-0.

Title:
Thymic epithelial cell development and differentiation: cellular and molecular regulation | Protein & Cell
Description:
Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.
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Keywords {🔍}

google, scholar, thymic, epithelial, cells, immunol, cell, development, medullary, thymus, differentiation, expression, aire, jenkinson, foxn, signaling, exp, med, required, factor, gene, blood, anderson, lymphotoxin, growth, article, cortical, progenitor, wnt, epithelium, takahama, essential, mice, regulate, selection, role, sci, boehm, nature, manley, protein, regulation, autoimmune, regulates, immunity, hollander, organogenesis, plos, sun, thymocytes,

Topics {✒️}

experimental graft-versus-host disease transcription factors foxn1 aire-expressing epithelial cells regulate aire-dependent transcripts peripheral t-cell reconstitution hongran li & yong zhao fibroblast growth factor thymic stroma-dependent manner end-stage terminal differentiation postnatal tissue-specific disruption nf-kappab signaling system ccr9-mediated chemokine signals tumor necrosis factor aire-dependent gene regulation thymic epithelial senescence thymic epithelial cells autoreactive cd4+ thymocytes lymphotoxin beta receptor mediating thymocyte positive keratinocyte growth factor thymic epithelial differentiation thymic hyper-cellularity murine thymus anlage medullary epithelial compartment cells expressing claudin aire-deficient thymus cell-cell interaction thymic medullary microenvironment thymic stromal cells epithelial terminal differentiation early thymic atrophy t-cell selection privacy choices/manage cookies thymic epithelial progenitors common bipotent progenitor aire-dependent pathway medullary thymic epithelium postnatal thymic microenvironment promotes terminal differentiation thymus-specific proteasomes antigen presenting cells wnt glycoproteins regulate mouse thymus gland radioresistant stromal cells ikappab kinase alpha cell lineage commitment medullary sublineage divergence cell developmental progression planar cell polarity keratinocyte-specific autoantigens

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WebPage:
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         headline:Thymic epithelial cell development and differentiation: cellular and molecular regulation
         description:Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.
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      headline:Thymic epithelial cell development and differentiation: cellular and molecular regulation
      description:Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.
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         thymic epithelial cells
         Aire
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         TNFR
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         FGFs
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         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
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