We are analyzing https://link.springer.com/article/10.1007/s13238-013-0001-4.

Title:
Inflammasomes in cancer: a double-edged sword | Protein & Cell
Description:
Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during inflammation, are large protein complexes typically consisting of a Nod-like receptor (NLR), the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific context. Here we summarize the role of different inflammasome complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro-inflammatory cytokines play in immunity.
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Keywords {🔍}

article, google, scholar, cancer, inflammasome, nlrp, cells, activation, inflammasomes, caspase, ilβ, cell, inflammation, tumorigenesis, asc, tumor, mice, role, expression, interleukin, studies, cancers, melanoma, colon, roles, breast, immunol, liu, study, epithelial, protein, immunity, aim, including, development, receptor, progression, death, immune, skin, usa, function, inflammatory, activated, nlrc, signaling, secretion, model, human, nature,

Topics {✒️}

tumor necrosis factor-α decreased nf-κb activity myeloid-derived suppressor cells il-1 beta-converting enzyme article download pdf paad/pyrin-family protein asc keratinocyte-derived asc inhibits nf-κb-mediated transcription cytosolic double-stranded dna noncanonical nf-κb signaling azoxymethane/dextran sodium sulphate double-edged sword il-1β neutralizing antibody il-1beta promotes stemness hepatocyte necrosis induced paad/pyrin-family proteins il-1β neutralizing antibodies suppressing dss-induced inflammation caspase-1 activates pro-il-1β tumor-antigen specific type-1 aom/dss-induced cac decreased dss-induced inflammation blocking il-1β signaling aom/dss-induced tumorigenesis tumor-infiltrating immune cells il-1rn genes increase tissue-specific opposing functions releases active il-1β inflammation-induced gi cancers aom/dss cac model guang-hui liu weizhou zhang declare b16-f10 melanomas tumor microenvironment privacy choices/manage cookies regulates immune responses adaptive immune responses helicobacter pylori infection early mammary tumourigenesis pro-inflammatory cytokines play virus activates interleukin-1beta anti-tumor vaccines major cytokine involved recombinant il-1rn paad-family proteins conditional knockout mice tumor immune responses anti-tumor vaccine animal facilities resulting promote tumor growth

Questions {❓}

Coussens LM, Zitvogel L, Palucka AK (2013) Neutralizing tumor-promoting chronic inflammation: a magic bullet?
Green DR, Kroemer G (2005) Pharmacological manipulation of cell death: clinical applications in sight?

Schema {🗺️}

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         headline:Inflammasomes in cancer: a double-edged sword
         description:Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during inflammation, are large protein complexes typically consisting of a Nod-like receptor (NLR), the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific context. Here we summarize the role of different inflammasome complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro-inflammatory cytokines play in immunity.
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      headline:Inflammasomes in cancer: a double-edged sword
      description:Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers of interleukin (IL)-1β and IL-18 during inflammation, are large protein complexes typically consisting of a Nod-like receptor (NLR), the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific context. Here we summarize the role of different inflammasome complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro-inflammatory cytokines play in immunity.
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         cancer
         inflammation
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         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
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               type:PostalAddress
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               name:Veterans Affairs Medical Center, Iowa City, USA
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      name:Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
      name:Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, USA
      name:Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
      name:Veterans Affairs Medical Center, Iowa City, USA
      name:Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA

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