We are analyzing https://link.springer.com/article/10.1007/s13238-010-0078-y.

Title:
Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting | Protein & Cell
Description:
Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells (GSCs) promotes therapeutic resistance. We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth, which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs. Furthermore, stem cell-like cancer cells (cancer stem cells) have been shown to promote metastasis. Although GBMs rarely metastasize beyond the central nervous system, these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection, and GSCs display an aggressive invasive phenotype. These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment. Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells, but also display critical distinctions that provide important clues into useful therapeutic targets. In this review, we summarize the current understanding and advances in glioma stem cell research, and discuss potential targeting strategies for future development of anti-GSC therapies.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, cells, stem, cell, cancer, glioblastoma, human, tumor, glioma, nature, res, brain, growth, neural, signaling, rich, pathway, mouse, wang, differentiation, therapeutic, tumors, proc, natl, acad, sci, notch, embryonic, med, lee, park, bao, proliferation, adult, identification, mclendon, hjelmeland, stemlike, zhang, expression, biol, medulloblastoma, article, targeting, gliomas, clarke, factor, nat, lathia,

Topics {✒️}

sry-related hmg-box factors pten/pi3k/akt pathway regulates human colon-cancer-initiating cells a2b5+cd133-tumor-initiating cells transforming growth factor-beta glioma cd133-positive cells neural stem/progenitor cells niche cell-cell interactions ink4a/arf-independent manner embryonic stem cells serum-cultured cell lines qiulian wu & shideng bao neural stem cells motor neuron/oligodendrocyte connection tumor-initiating cells initiating tumour growth stromal-derived factor 1 promotes therapeutic resistance cancer therapeutic resistance tumour-initiating cells glioma-initiating cells glioma stem cells erythropoietin receptor signaling brain tumor hypoxia glioma tumor stem glioblastoma-initiating cells glioblastoma stem cells pluripotent stem cells human tumor cells glioblastoma multiforme cells cancer stem cells hedgehog pathway inhibitor glioblastoma—molecular signaling neuronal repressor rest/nrsf dna damage response promotes tumor growth crypt stem cells hematopoietic stem cells patched-1-deficient mouse medulloblastoma human glioblastoma multiforme cancer stem cell anti-gsc therapies akt inhibits growth cancerous stem cells neoplastic stem cells cancer brain tumor tumor-propagating cells human neuroblastoma cells glioma progenitor cells related subjects

Questions {❓}

Cancer stem cells: mirage or reality?

Schema {🗺️}

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         headline:Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting
         description:Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells (GSCs) promotes therapeutic resistance. We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth, which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs. Furthermore, stem cell-like cancer cells (cancer stem cells) have been shown to promote metastasis. Although GBMs rarely metastasize beyond the central nervous system, these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection, and GSCs display an aggressive invasive phenotype. These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment. Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells, but also display critical distinctions that provide important clues into useful therapeutic targets. In this review, we summarize the current understanding and advances in glioma stem cell research, and discuss potential targeting strategies for future development of anti-GSC therapies.
         datePublished:2010-07-29T00:00:00Z
         dateModified:2010-07-29T00:00:00Z
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      headline:Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting
      description:Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells (GSCs) promotes therapeutic resistance. We also found that GSCs stimulate tumor angiogenesis by expressing elevated levels of VEGF and contribute to tumor growth, which has been translated into a useful therapeutic strategy in the treatment of recurrent or progressive GBMs. Furthermore, stem cell-like cancer cells (cancer stem cells) have been shown to promote metastasis. Although GBMs rarely metastasize beyond the central nervous system, these highly infiltrative cancers often invade into normal brain tissues preventing surgical resection, and GSCs display an aggressive invasive phenotype. These studies suggest that targeting GSCs may effectively reduce tumor recurrence and significantly improve GBM treatment. Recent studies indicate that cancer stem cells share core signaling pathways with normal somatic or embryonic stem cells, but also display critical distinctions that provide important clues into useful therapeutic targets. In this review, we summarize the current understanding and advances in glioma stem cell research, and discuss potential targeting strategies for future development of anti-GSC therapies.
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         glioblastoma
         therapeutic resistance
         molecular targeting
         tumor angiogenesis
         hypoxia response
         stem cell niche
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         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
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      name:Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, USA
      name:Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, USA

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