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Title:
Pyroptosis in inflammation-related respiratory disease | Journal of Physiology and Biochemistry
Description:
Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.
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Keywords {🔍}
pyroptosis, pubmed, article, google, scholar, cas, nlrp, inflammasome, pathway, caspase, lung, inflammation, pulmonary, activation, cell, cells, signaling, central, cancer, role, inflammatory, protein, mtb, gsdmd, wang, macrophages, results, reported, important, asthma, additionally, activated, diseases, induces, gasdermin, airway, respiratory, inflammasomeinduced, increased, leads, ams, ilβ, ali, fibrosis, inflammasomes, aim, activating, fig, pathways, copd,
Topics {✒️}
perk/eif2α/txnip/nlrp3/caspase-1/gsdmd-mediated pyroptosis ros/nf-κb/nlrp3/gsdmd signal axis tlrs/myd88/nf-κb signaling pathway triggering tlr4/nlrp3/gsdmd-dependent pyroptosis tlr2/nf-κb signaling pathway tlr4/nf-κb signaling pathway advanced tumor-node-metastasis stage rack1/nlrp3/caspase-1/gsdmd signaling pathway ros/txnip/nlrp3/caspase-1 signaling pathway tlr4/nlrp3/caspase-1/gsdmd pathway nlrp3/caspase-1/gsdmd signaling pathway article download pdf tlr4/md2/cd14 complex advanced glycation end-products nlrp3/asc/caspase-1 signaling pathway nlrp3/caspase-1/gsdmd-mediated pyroptosis il-1β/il-18/il-6/stat3 pathway caspase-3/gsdme-dependent pyroptosis mediated caspase-3/gsdme-mediated pyroptosis enhances nlrp3/caspase-1/gsdmd-dependent pyroptosis outer membrane vesicles nlrp3/caspase-1/gsdmd-induced pyroptosis ros/txnip/nlrp3/caspase-1 pathway p2x7r-paxillin-nlrp3 complex activates atp/p2x7r signaling pathway pore-forming protein-induced pyroptosis pyroptosis-il-1β immune pathway tlr4/nlrp3/caspase-1 pathway tlr4/rip1 signaling pathway inflammation-related respiratory disease /caspase-11/gsdmd signaling pathway nlrp3/caspase-1 signaling pathway canonical inflammasome-induced pathway canonical inflammasome-induced pathway perk/eif2α/chop pathway nlrp3/caspase-1/gsdmd axis [12] p2x7r/nlrp3/caspase-1 axis [20] caspase-1 cleaves pro-il-1β inflammation-related respiratory diseases nlrp3 inflammasome-induced pathway perk/txnip/nlrp3 axis tumor necrosis factor-alpha canonical inflammasome-induced pathways canonical inflammasome-induced pathways silica-induced pulmonary inflammation cytoplasmic double-stranded dna anthrax lethal toxin caspase-11/gsdmd-mediated pyroptosis nlrp3/gsdmd-mediated pyroptosis nucleotide-binding oligomerization domain
Questions {❓}
- Patterson KC, Queval CJ, Gutierrez MG (2019) Granulomatous inflammation in tuberculosis and sarcoidosis: does the lymphatic system contribute to disease?
- Vecchié A, Bonaventura A, Toldo S, Dagna L, Dinarello CA, Abbate A (2021) IL-18 and infections: is there a role for targeted therapies?
- Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J et al (2019) The role of pyroptosis in cancer: pro-cancer or pro-“host”?
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headline:Pyroptosis in inflammation-related respiratory disease
description:Pyroptosis
is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.
datePublished:2022-07-11T00:00:00Z
dateModified:2022-07-11T00:00:00Z
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license:http://creativecommons.org/licenses/by/4.0/
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Pyroptosis
Inflammation
Respiratory diseases
Inflammasomes
Gasdermin
Caspase-1
Biomedicine
general
Human Physiology
Animal Physiology
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headline:Pyroptosis in inflammation-related respiratory disease
description:Pyroptosis
is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.
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Pyroptosis
Inflammation
Respiratory diseases
Inflammasomes
Gasdermin
Caspase-1
Biomedicine
general
Human Physiology
Animal Physiology
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