We are analyzing https://link.springer.com/article/10.1007/s12975-013-0283-0.

Title:
Mitochondrial Dysfunction Induced by Nuclear Poly(ADP-Ribose) Polymerase-1: a Treatable Cause of Cell Death in Stroke | Translational Stroke Research
Description:
Many drugs targeting excitotoxic cell death have demonstrated robust neuroprotective effects in animal models of cerebral ischemia. However, these neuroprotective effects have almost universally required drug administration at relatively short time intervals after ischemia onset. This finding has translated to clinical trial results; interventions targeting excitotoxicity have had no demonstrable efficacy when initiated hours after ischemia onset, but beneficial effects have been reported with more rapid initiation. Consequently, there continues to be a need for interventions with efficacy at later time points after ischemia. Here, we focus on mitochondrial dysfunction as both a relatively late event in ischemic neuronal death and a recognized cause of delayed neuronal death. Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a primary cause of mitochondrial depolarization and subsequent mitochondria-triggered cell death in ischemia reperfusion. PARP-1 consumes cytosolic NAD+, thereby blocking both glycolytic ATP production and delivery of glucose carbon to mitochondria for oxidative metabolism. However, ketone bodies such as pyruvate, beta- and gamma-hydroxybutyrate, and 1,4-butanediol can fuel mitochondrial metabolism in cells with depleted cytosolic NAD+ as long as the mitochondria remain functional. Ketone bodies have repeatedly been shown to be highly effective in preventing cell death in animal models of ischemia, but a rigorous study of the time window of opportunity for this approach remains to be performed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, google, scholar, article, cas, death, cell, cerebral, brain, ischemia, polyadpribose, mitochondrial, swanson, stroke, central, polymerase, neuronal, focal, pyruvate, neurosci, rat, ischemic, metab, transient, apoptosis, cereb, blood, flow, res, nad, mitochondria, injury, wang, chen, activation, glutamate, damage, pharmacol, kim, protection, research, models, nmda, protects, dis, sci, permeability, transition, lee, privacy,

Topics {✒️}

n-methyl-d-aspartate receptor antagonist ascorbate/menadione-induced oxidative stress n-methyl-d-aspartate receptors n-methyl-d-aspartate antagonists month download article/chapter n-methyl-d-aspartate mitochondrial apoptosis-inducing factor ischemia-induced hippocampal neurodegeneration cerebral ischemia-induced neurodegeneration hypoxic-ischemic brain injury polymer-induced cell death mitochondrial dysfunction induced polymerase-1-mediated cell death polymerase-1-mediated neuronal death full article pdf mitochondrial permeability transition yu sw apoptotic neuronal death ceramide-induced apoptosis ischemic neuronal death privacy choices/manage cookies alano cc fuel glutamate uptake excitotoxic cell death cerebral ischemic injury giffard rg preventing cell death cell death differ cell death caused anti-cell death excitotoxic neuronal death brain dysfunctions induced focal cerebral damage delayed neuronal death hypoglycemic neuronal death necrotic cell death ischemic damage caused ischemic brain injury california san francisco ischemic brain damage central executioner related subjects andrabi sa cellular response focal cerebral ischemia cell death dis simon rp article baxter selective cell loss nicholls dg

Questions {❓}

Apoptosis after experimental stroke: fact or fashion?
The mitochondrial permeability transition pore: a mystery solved?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Mitochondrial Dysfunction Induced by Nuclear Poly(ADP-Ribose) Polymerase-1: a Treatable Cause of Cell Death in Stroke
         description:Many drugs targeting excitotoxic cell death have demonstrated robust neuroprotective effects in animal models of cerebral ischemia. However, these neuroprotective effects have almost universally required drug administration at relatively short time intervals after ischemia onset. This finding has translated to clinical trial results; interventions targeting excitotoxicity have had no demonstrable efficacy when initiated hours after ischemia onset, but beneficial effects have been reported with more rapid initiation. Consequently, there continues to be a need for interventions with efficacy at later time points after ischemia. Here, we focus on mitochondrial dysfunction as both a relatively late event in ischemic neuronal death and a recognized cause of delayed neuronal death. Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a primary cause of mitochondrial depolarization and subsequent mitochondria-triggered cell death in ischemia reperfusion. PARP-1 consumes cytosolic NAD+, thereby blocking both glycolytic ATP production and delivery of glucose carbon to mitochondria for oxidative metabolism. However, ketone bodies such as pyruvate, beta- and gamma-hydroxybutyrate, and 1,4-butanediol can fuel mitochondrial metabolism in cells with depleted cytosolic NAD+ as long as the mitochondria remain functional. Ketone bodies have repeatedly been shown to be highly effective in preventing cell death in animal models of ischemia, but a rigorous study of the time window of opportunity for this approach remains to be performed.
         datePublished:2013-09-07T00:00:00Z
         dateModified:2013-09-07T00:00:00Z
         pageStart:136
         pageEnd:144
         sameAs:https://doi.org/10.1007/s12975-013-0283-0
         keywords:
            Ischemia
            Mitochondrial depolarization
            Mitochondrial permeability transition
            Poly(ADP-ribose) polymerase-1
            NAD+
            Apoptosis-inducing factor
            Neurosciences
            Neurology
            Cardiology
            Neurosurgery
            Vascular Surgery
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig4_HTML.gif
         isPartOf:
            name:Translational Stroke Research
            issn:
               1868-601X
               1868-4483
            volumeNumber:5
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Paul Baxter
               affiliation:
                     name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                     address:
                        name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yanting Chen
               affiliation:
                     name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                     address:
                        name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yun Xu
               affiliation:
                     name:Affiliated Drum Tower Hospital of Nanjing University Medical School
                     address:
                        name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Raymond A. Swanson
               affiliation:
                     name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                     address:
                        name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Mitochondrial Dysfunction Induced by Nuclear Poly(ADP-Ribose) Polymerase-1: a Treatable Cause of Cell Death in Stroke
      description:Many drugs targeting excitotoxic cell death have demonstrated robust neuroprotective effects in animal models of cerebral ischemia. However, these neuroprotective effects have almost universally required drug administration at relatively short time intervals after ischemia onset. This finding has translated to clinical trial results; interventions targeting excitotoxicity have had no demonstrable efficacy when initiated hours after ischemia onset, but beneficial effects have been reported with more rapid initiation. Consequently, there continues to be a need for interventions with efficacy at later time points after ischemia. Here, we focus on mitochondrial dysfunction as both a relatively late event in ischemic neuronal death and a recognized cause of delayed neuronal death. Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a primary cause of mitochondrial depolarization and subsequent mitochondria-triggered cell death in ischemia reperfusion. PARP-1 consumes cytosolic NAD+, thereby blocking both glycolytic ATP production and delivery of glucose carbon to mitochondria for oxidative metabolism. However, ketone bodies such as pyruvate, beta- and gamma-hydroxybutyrate, and 1,4-butanediol can fuel mitochondrial metabolism in cells with depleted cytosolic NAD+ as long as the mitochondria remain functional. Ketone bodies have repeatedly been shown to be highly effective in preventing cell death in animal models of ischemia, but a rigorous study of the time window of opportunity for this approach remains to be performed.
      datePublished:2013-09-07T00:00:00Z
      dateModified:2013-09-07T00:00:00Z
      pageStart:136
      pageEnd:144
      sameAs:https://doi.org/10.1007/s12975-013-0283-0
      keywords:
         Ischemia
         Mitochondrial depolarization
         Mitochondrial permeability transition
         Poly(ADP-ribose) polymerase-1
         NAD+
         Apoptosis-inducing factor
         Neurosciences
         Neurology
         Cardiology
         Neurosurgery
         Vascular Surgery
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12975-013-0283-0/MediaObjects/12975_2013_283_Fig4_HTML.gif
      isPartOf:
         name:Translational Stroke Research
         issn:
            1868-601X
            1868-4483
         volumeNumber:5
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Paul Baxter
            affiliation:
                  name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                  address:
                     name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yanting Chen
            affiliation:
                  name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                  address:
                     name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yun Xu
            affiliation:
                  name:Affiliated Drum Tower Hospital of Nanjing University Medical School
                  address:
                     name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Raymond A. Swanson
            affiliation:
                  name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
                  address:
                     name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Translational Stroke Research
      issn:
         1868-601X
         1868-4483
      volumeNumber:5
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
      address:
         name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
         type:PostalAddress
      name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
      address:
         name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
         type:PostalAddress
      name:Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
         type:PostalAddress
      name:Affiliated Drum Tower Hospital of Nanjing University Medical School
      address:
         name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
         type:PostalAddress
      name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
      address:
         name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Paul Baxter
      affiliation:
            name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
            address:
               name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Yanting Chen
      affiliation:
            name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
            address:
               name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yun Xu
      affiliation:
            name:Affiliated Drum Tower Hospital of Nanjing University Medical School
            address:
               name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Raymond A. Swanson
      affiliation:
            name:University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center
            address:
               name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
      name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
      name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
      name:Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China
      name:Department of Neurology, University of California San Francisco and Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(289)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.62s.

LINK . SPRINGER . COM {}