We are analyzing https://link.springer.com/article/10.1007/s12640-011-9277-4.

Title:
Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death | Neurotoxicity Research
Description:
Currently, there is no effective treatment for neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Thus, a major focus of neuroscience research is to examine the mechanisms involved in neuronal loss in order to identify potential drug targets. Recent results indicate that DNA damage and re-entry into the cell cycle may constitute a common pathway in apoptosis in neurological diseases. The role of the cell cycle in such disorders is supported by data on the brain of patients who showed an increase in cell-cycle protein expression. Indeed, studies performed in neuronal cell preparations indicate that oxidative stress could be the main mechanism responsible for cell cycle re-entry. DNA damage and repair after oxidative stress may activate the enzyme ataxia telangiectasia mutated, which is a cell-cycle regulator. Once the cell cycle is activated, the increase in the expression of transcription factor E2F-1 could induce neuronal apoptosis. Furthermore, the potential routes involved in E2F-1 induced apoptosis could be p53-dependent or p53-independent. Under this E2F-1 hypothesis of cell death, multiple mitochondria-dependent pathways may be activated, including caspase and caspase-independent signaling cascades. Finally, given that cyclin-dependent kinase inhibitory drugs have neuroprotective and anti-apoptotic effects in experimental models, their potential application for the treatment of neurological disorders should be taken into account.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

google, scholar, pubmed, cas, cell, cycle, disease, death, neuronal, apoptosis, alzheimers, neurons, neurosci, res, park, dna, cyclindependent, cdk, smith, biol, activation, role, brain, mol, camins, expression, article, verdaguer, cellcycle, kinase, lee, kinases, reentry, pallàs, pathway, transcription, proteins, chem, neurochem, cerebellar, granule, zhu, neurodegeneration, slack, damage, protein, factor, inhibition, sci, target,

Topics {✒️}

ta-promoter-derived deltan’-p73 transcript cyclin-dependent kinases cdk2 ataxia telangiectasia-p53–e2f-1 pathway month download article/chapter traumatic brain injury cyclin-dependent kinase inhibitors cell cycle-related proteins 1-methyl-4-phenylpyridinium-induced apoptosis b-amyloid-treated cortical neurons transcription factor e2f1/rb promotes e2f1-induced apoptosis potassium withdrawal-induced apoptosis b-myb promoter activity death-receptor-mediated apoptosis increased deltan-p73 expression kainic acid-induced apoptosis jordan-sciutto kl e2f-dependent gene repression kainic acid-induced death ischemia/hypoxic neuronal death cell-cycle protein expression dna damage-induced apoptosis calpain/cdk5/p25 pathway sh-sy5y neuroblastoma cells e2f1 mediates apoptosis facultat de biologia cyclin-dependent kinases cyclin dependent kinases phase cell-cycle regulators multiple mitochondria-dependent pathways g1 cell-cycle control neural-specific regulatory subunit cyclin-dependent kinase 5 e2f1 mediates death caspase-independent signaling cascades neuronal apoptosis evoked transcription factor e2f-1 cell cycle pathway e2f1 induces apoptosis cell cycle proteins e2f-1 induced apoptosis e2f-1-induced apoptosis potassium-induced apoptosis transcription factor e2f1 neuronal death evoked e2f1-induced apoptosis cell death induced neuronal death induced cerebellar granule cells related subjects

Questions {❓}

Chong ZZ, Li F, Maiese K (2005) Employing new cellular therapeutic targets for Alzheimer’s disease: a change for the better?
Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M (2001) Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?
Kruman II (2004) Why do neurons enter the cell cycle?
Tsai LH, Lee MS, Cruz J (2004) Cdk5, a therapeutic target for Alzheimer’s disease?
Vincent I, Rosado M, Davies P (1996) Mitotic mechanisms in Alzheimer’s disease?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death
         description:Currently, there is no effective treatment for neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Thus, a major focus of neuroscience research is to examine the mechanisms involved in neuronal loss in order to identify potential drug targets. Recent results indicate that DNA damage and re-entry into the cell cycle may constitute a common pathway in apoptosis in neurological diseases. The role of the cell cycle in such disorders is supported by data on the brain of patients who showed an increase in cell-cycle protein expression. Indeed, studies performed in neuronal cell preparations indicate that oxidative stress could be the main mechanism responsible for cell cycle re-entry. DNA damage and repair after oxidative stress may activate the enzyme ataxia telangiectasia mutated, which is a cell-cycle regulator. Once the cell cycle is activated, the increase in the expression of transcription factor E2F-1 could induce neuronal apoptosis. Furthermore, the potential routes involved in E2F-1 induced apoptosis could be p53-dependent or p53-independent. Under this E2F-1 hypothesis of cell death, multiple mitochondria-dependent pathways may be activated, including caspase and caspase-independent signaling cascades. Finally, given that cyclin-dependent kinase inhibitory drugs have neuroprotective and anti-apoptotic effects in experimental models, their potential application for the treatment of neurological disorders should be taken into account.
         datePublished:2011-10-01T00:00:00Z
         dateModified:2011-10-01T00:00:00Z
         pageStart:195
         pageEnd:207
         sameAs:https://doi.org/10.1007/s12640-011-9277-4
         keywords:
            E2F-1
            Cyclin-dependent kinases
            CDK5
            p53
            Alzheimer’s disease
            Parkinson’s disease
            Neurosciences
            Neurology
            Neurochemistry
            Pharmacology/Toxicology
            Neurobiology
            Cell Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig3_HTML.gif
         isPartOf:
            name:Neurotoxicity Research
            issn:
               1476-3524
               1029-8428
            volumeNumber:22
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jaume Folch
               affiliation:
                     name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
                     address:
                        name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Felix Junyent
               affiliation:
                     name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                     address:
                        name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
                     address:
                        name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ester Verdaguer
               affiliation:
                     name:Universitat de Barcelona
                     address:
                        name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carme Auladell
               affiliation:
                     name:Universitat de Barcelona
                     address:
                        name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Javier G. Pizarro
               affiliation:
                     name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                     address:
                        name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Beas-Zarate
               affiliation:
                     name:Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)
                     address:
                        name:Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mercè Pallàs
               affiliation:
                     name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                     address:
                        name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Antoni Camins
               affiliation:
                     name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                     address:
                        name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death
      description:Currently, there is no effective treatment for neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Thus, a major focus of neuroscience research is to examine the mechanisms involved in neuronal loss in order to identify potential drug targets. Recent results indicate that DNA damage and re-entry into the cell cycle may constitute a common pathway in apoptosis in neurological diseases. The role of the cell cycle in such disorders is supported by data on the brain of patients who showed an increase in cell-cycle protein expression. Indeed, studies performed in neuronal cell preparations indicate that oxidative stress could be the main mechanism responsible for cell cycle re-entry. DNA damage and repair after oxidative stress may activate the enzyme ataxia telangiectasia mutated, which is a cell-cycle regulator. Once the cell cycle is activated, the increase in the expression of transcription factor E2F-1 could induce neuronal apoptosis. Furthermore, the potential routes involved in E2F-1 induced apoptosis could be p53-dependent or p53-independent. Under this E2F-1 hypothesis of cell death, multiple mitochondria-dependent pathways may be activated, including caspase and caspase-independent signaling cascades. Finally, given that cyclin-dependent kinase inhibitory drugs have neuroprotective and anti-apoptotic effects in experimental models, their potential application for the treatment of neurological disorders should be taken into account.
      datePublished:2011-10-01T00:00:00Z
      dateModified:2011-10-01T00:00:00Z
      pageStart:195
      pageEnd:207
      sameAs:https://doi.org/10.1007/s12640-011-9277-4
      keywords:
         E2F-1
         Cyclin-dependent kinases
         CDK5
         p53
         Alzheimer’s disease
         Parkinson’s disease
         Neurosciences
         Neurology
         Neurochemistry
         Pharmacology/Toxicology
         Neurobiology
         Cell Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12640-011-9277-4/MediaObjects/12640_2011_9277_Fig3_HTML.gif
      isPartOf:
         name:Neurotoxicity Research
         issn:
            1476-3524
            1029-8428
         volumeNumber:22
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jaume Folch
            affiliation:
                  name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
                  address:
                     name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Felix Junyent
            affiliation:
                  name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                  address:
                     name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
                  address:
                     name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ester Verdaguer
            affiliation:
                  name:Universitat de Barcelona
                  address:
                     name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carme Auladell
            affiliation:
                  name:Universitat de Barcelona
                  address:
                     name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Javier G. Pizarro
            affiliation:
                  name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                  address:
                     name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Beas-Zarate
            affiliation:
                  name:Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)
                  address:
                     name:Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mercè Pallàs
            affiliation:
                  name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                  address:
                     name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Antoni Camins
            affiliation:
                  name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
                  address:
                     name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Neurotoxicity Research
      issn:
         1476-3524
         1029-8428
      volumeNumber:22
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
      address:
         name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
         type:PostalAddress
      name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
      address:
         name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
         type:PostalAddress
      name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
      address:
         name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
         type:PostalAddress
      name:Universitat de Barcelona
      address:
         name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:Universitat de Barcelona
      address:
         name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
      address:
         name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
         type:PostalAddress
      name:Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)
      address:
         name:Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico
         type:PostalAddress
      name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
      address:
         name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
         type:PostalAddress
      name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
      address:
         name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jaume Folch
      affiliation:
            name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
            address:
               name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
               type:PostalAddress
            type:Organization
      name:Felix Junyent
      affiliation:
            name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
            address:
               name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili
            address:
               name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
               type:PostalAddress
            type:Organization
      name:Ester Verdaguer
      affiliation:
            name:Universitat de Barcelona
            address:
               name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Carme Auladell
      affiliation:
            name:Universitat de Barcelona
            address:
               name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Javier G. Pizarro
      affiliation:
            name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
            address:
               name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Carlos Beas-Zarate
      affiliation:
            name:Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)
            address:
               name:Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico
               type:PostalAddress
            type:Organization
      name:Mercè Pallàs
      affiliation:
            name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
            address:
               name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Antoni Camins
      affiliation:
            name:Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes
            address:
               name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
      name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
      name:Unitat de Bioquimica, Facultat de Medicina i Ciències de la Salut, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, Reus, Spain
      name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
      name:Departament de Biologia Cel·lular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
      name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
      name:Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara and División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico
      name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
      name:Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Institut de Biomedicina (IBUB), Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(317)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.52s.

LINK . SPRINGER . COM {}