We are analyzing https://link.springer.com/article/10.1007/s12640-009-9050-0.

Title:
Cell Cycle Activation and CNS Injury | Neurotoxicity Research
Description:
Although traditionally it was believed that adult neurons have entered a permanent post-mitotic phase, the latest experimental data indicate that cell cycle constituents critically affect normal functions of the adult central nervous system (CNS), as well as contribute to the pathophysiology of both acute and chronic neurodegenerative disorders. Recent study has also suggested that cell cycle pathways are involved in mediating not only neuronal cell death but also glial changes which may play key roles in the pathophysiological mechanisms underlying acute and chronic neurodegenerative disorders. Therefore, therapies that inhibit cell cycle may have robust neuroprotective profiles, particularly after acute insults, by targeting multiple pathogenic mechanisms and could be useful clinically if used with a delivery focused on specific areas and of a limited duration.
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Keywords {🔍}

google, scholar, pubmed, cas, article, cell, cycle, death, neurosci, neuronal, neurons, disease, dna, alzheimers, brain, biol, kinase, expression, activation, apoptosis, res, protein, injury, herrup, wang, cyclindependent, park, cyclin, sci, yang, chem, development, greene, faden, acad, damage, ischemia, mol, postmitotic, usa, arendt, neurol, cdk, neuron, lee, kinases, proc, natl, role, response,

Topics {✒️}

peroxisome proliferator-activated receptor-gamma month download article/chapter strain-dependent myeloid hyperplasia jordan-sciutto kl retinoblastoma-related p130 gene cyclin-dependent kinase activity mitogen-activated protein kinase strain-dependent embryonic lethality e2f-dependent gene repression cyclin-dependent kinases cdc2 base modification 8-hydroxyl-2’-deoxyguanosine romito-digiacomo rr cdc2-related protein kinase linking cell-cycle dysfunction phase cell-cycle regulators rb-related p107 gene distinct cyclin-cdk complexes permanent post-mitotic phase cyclin-dependent kinase inhibitors p25/cdk5-mediated retinoblastoma phosphorylation regulates msds3-mediated repression ischemia/hypoxic neuronal death constitutive c-myc expression kainic acid-induced apoptosis p53-independent nuclear translocation post-mitotic cell death amyloid precursor protein cell cycle events chronic neurodegenerative disorders hormone-regulated apoptosis results central nervous system cdk5/p35 phosphorylates msds3 pro-apoptotic bim induction nerve growth factor cyclin-dependent kinases full article pdf transgenic mouse models neuronal death induced cyclin-dependent kinase 5 cyclin-dependent kinase 4 neuronal cell cycle neuronal death pathway anti-cancer drug flavopiridol cell cycle pathways cerebral ischemia hypoxia stroke-induced neurogenesis cell cycle inhibition cell cycle molecules cell cycle regulators precedes neurofibrillary degeneration

Questions {❓}

Copani A, Sortino MA, Nicoletti F, Giuffrida SA (2002a) Alzheimer’s disease research enters a “new cycle”: how significant?
Copani A, Uberti D, Sortino MA, Bruno V, Nicoletti F, Memo M (2001) Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?
Herrup K, Yang Y (2007) Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
Kruman II (2004) Why do neurons enter the cell cycle?
Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA (2003) Ectopic localization of phosphorylated histone H3 in Alzheimer’s disease: a mitotic catastrophe?
Role in aging?
Timsit S, Rivera S, Ouaghi P, Guischard F, Tremblay E, Ben-Ari Y, Khrestchatisky M (1999) Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?
Ucker DS (1991) Death by suicide: one way to go in mammalian cellular development?
Yang Y, Herrup K (2007) Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

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